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Protein

GemA protein

Gene

gemA

Organism
Escherichia phage Mu (Bacteriophage Mu)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Early protein responsible for decreasing host DNA gyrase activity. Promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host cell cycle by virus, Viral latency

Names & Taxonomyi

Protein namesi
Recommended name:
GemA protein
Alternative name(s):
Gene product 16
Short name:
gp16
Gene namesi
Name:gemA
Ordered Locus Names:Mup16
OrganismiEscherichia phage Mu (Bacteriophage Mu)
Taxonomic identifieri10677 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeMuvirus
Virus hostiEnterobacteriaceae [TaxID: 543]
Proteomesi
  • UP000002611 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000778111 – 183GemA proteinAdd BLAST183

Proteomic databases

PRIDEiQ38494.

Expressioni

Inductioni

This protein is constitively expressed from the Pgem promoter unlike most other early proteins which are expressed under the control of the Pe promoter. Its expression seems to escape repression by repressor protein c and thus occurs throughout latency (Probable).1 Publication

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the mulikevirus gemA protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000U3.

Family and domain databases

InterProiView protein in InterPro
IPR009363. Phage_Mu_Gp16.
PfamiView protein in Pfam
PF06252. DUF1018. 1 hit.

Sequencei

Sequence statusi: Complete.

Q38494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTSLIKLI HVARRELQLD DDTYRAFLMQ KTGKISCREL TVTQLEQVLG
60 70 80 90 100
AMKERGFKKQ NKYPRRRFKG HVTPREKVYK IWQQMAEDGF ITDGGDVALD
110 120 130 140 150
KYVQRLTAKR NGGQGVSTLA WCHGDTLLTV LETLKQWHIR CIREAFSRHG
160 170 180
LPLPVSPSGR ELRGYDAMTA AYAHARKTRR MAQ
Length:183
Mass (Da):21,089
Last modified:December 1, 2000 - v2
Checksum:iCD8278C9CE0B3C3D
GO

Sequence cautioni

The sequence AAA32406 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64097 Genomic DNA. Translation: AAA32406.1. Different initiation.
AF083977 Genomic DNA. Translation: AAF01093.1.
RefSeqiNP_050620.1. NC_000929.1.

Genome annotation databases

GeneIDi2636256.
KEGGivg:2636256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64097 Genomic DNA. Translation: AAA32406.1. Different initiation.
AF083977 Genomic DNA. Translation: AAF01093.1.
RefSeqiNP_050620.1. NC_000929.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ38494.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2636256.
KEGGivg:2636256.

Phylogenomic databases

OrthoDBiVOG090000U3.

Family and domain databases

InterProiView protein in InterPro
IPR009363. Phage_Mu_Gp16.
PfamiView protein in Pfam
PF06252. DUF1018. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGEMA_BPMU
AccessioniPrimary (citable) accession number: Q38494
Secondary accession number(s): Q9T1X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: March 15, 2017
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.