ID   Q383I8_TRYB2            Unreviewed;       277 AA.
AC   Q383I8;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   RecName: Full=Small ribosomal subunit protein uS2 {ECO:0000256|HAMAP-Rule:MF_03015};
GN   ORFNames=Tb11.01.2680 {ECO:0000313|EMBL:EAN80043.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN80043.1, ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:EAN80043.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN80043.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [2] {ECO:0007829|PDB:4V8M}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.57 ANGSTROMS).
RX   PubMed=23395961; DOI=10.1038/nature11872;
RA   Hashem Y., des Georges A., Fu J., Buss S.N., Jossinet F., Jobe A.,
RA   Zhang Q., Liao H.Y., Grassucci R.A., Bajaj C., Westhof E.,
RA   Madison-Antenucci S., Frank J.;
RT   "High-resolution cryo-electron microscopy structure of the Trypanosoma
RT   brucei ribosome.";
RL   Nature 494:385-389(2013).
CC   -!- FUNCTION: Required for the assembly and/or stability of the 40S
CC       ribosomal subunit. Required for the processing of the 20S rRNA-
CC       precursor to mature 18S rRNA in a late step of the maturation of 40S
CC       ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_03015}.
CC   -!- SUBUNIT: Component of the small ribosomal subunit. Mature ribosomes
CC       consist of a small (40S) and a large (60S) subunit. The 40S subunit
CC       contains about 33 different proteins and 1 molecule of RNA (18S). The
CC       60S subunit contains about 49 different proteins and 3 molecules of RNA
CC       (25S, 5.8S and 5S). Interacts with ribosomal protein S21.
CC       {ECO:0000256|HAMAP-Rule:MF_03015}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_03015}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS2 family.
CC       {ECO:0000256|ARBA:ARBA00006242, ECO:0000256|HAMAP-Rule:MF_03015,
CC       ECO:0000256|RuleBase:RU003631}.
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DR   EMBL; CH464491; EAN80043.1; -; Genomic_DNA.
DR   RefSeq; XP_829155.1; XM_824062.1.
DR   PDB; 4V8M; EM; 5.57 A; AC=1-277.
DR   PDBsum; 4V8M; -.
DR   AlphaFoldDB; Q383I8; -.
DR   EMDB; EMD-17208; -.
DR   EMDB; EMD-17212; -.
DR   IntAct; Q383I8; 1.
DR   STRING; 185431.Q383I8; -.
DR   PaxDb; 5691-EAN80043; -.
DR   GeneID; 3665659; -.
DR   KEGG; tbr:Tb11.01.2680; -.
DR   eggNOG; KOG0830; Eukaryota.
DR   InParanoid; Q383I8; -.
DR   OrthoDB; 5480124at2759; -.
DR   Proteomes; UP000008524; Chromosome 11 Scaffold 1.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IEA:UniProtKB-UniRule.
DR   GO; GO:0000314; C:organellar small ribosomal subunit; ISM:GeneDB.
DR   GO; GO:0003729; F:mRNA binding; IDA:GeneDB.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISM:GeneDB.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; ISM:GeneDB.
DR   CDD; cd01425; RPS2; 1.
DR   HAMAP; MF_03015; Ribosomal_S2_euk; 1.
DR   InterPro; IPR001865; Ribosomal_uS2.
DR   InterPro; IPR018130; Ribosomal_uS2_CS.
DR   InterPro; IPR027498; Ribosomal_uS2_euk.
DR   InterPro; IPR005707; Ribosomal_uS2_euk/arc.
DR   InterPro; IPR023591; Ribosomal_uS2_flav_dom_sf.
DR   NCBIfam; TIGR01012; uS2_euk_arch; 1.
DR   PANTHER; PTHR11489; 40S RIBOSOMAL PROTEIN SA; 1.
DR   PANTHER; PTHR11489:SF9; 40S RIBOSOMAL PROTEIN SA; 1.
DR   Pfam; PF00318; Ribosomal_S2; 1.
DR   PRINTS; PR00395; RIBOSOMALS2.
DR   SUPFAM; SSF52313; Ribosomal protein S2; 1.
DR   PROSITE; PS00963; RIBOSOMAL_S2_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4V8M};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03015};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274, ECO:0000256|HAMAP-
KW   Rule:MF_03015};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980, ECO:0000256|HAMAP-
KW   Rule:MF_03015}.
SQ   SEQUENCE   277 AA;  31354 MW;  B746058506B77D3B CRC64;
     MTETSRRDLI FLVLSPFSPS LSSKALRNSH TRNMTSVSSG AKVLRMKESD VQKLLAMHCH
     LGTKNSSSAM KKYIHGRTSD GTNIIDIHMT WEKLILAARV IAAVENPQDV TVCSTRLFGQ
     RAIFKFSQLV GTSFLGGRFI PGTFTNQIQK KFMQPRVLVV TDPRTDHQAL REASLVNIPV
     IAFCDTDAPL EFVDIAIPCN NRGRHSISMM YWLLAREVLR LRGTIPRSVP WEVKVDLFFY
     RDPEEALKQE EATAAAEVHE EADEGYGWVE RDNTWEQ
//