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Q38087 (DPOL_BPR69) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase

EC=2.7.7.7
Alternative name(s):
Gp43
Gene names
Name:43
OrganismEnterobacteria phage RB69 (Bacteriophage RB69) [Complete proteome]
Taxonomic identifier12353 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length903 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sequence similarities

Belongs to the DNA polymerase type-B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 903903DNA polymerase
PRO_0000046547

Secondary structure

............................................................................................................................................................... 903
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q38087 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A3983FC16D4C0509

FASTA903104,613
        10         20         30         40         50         60 
MKEFYLTVEQ IGDSIFERYI DSNGRERTRE VEYKPSLFAH CPESQATKYF DIYGKPCTRK 

        70         80         90        100        110        120 
LFANMRDASQ WIKRMEDIGL EALGMDDFKL AYLSDTYNYE IKYDHTKIRV ANFDIEVTSP 

       130        140        150        160        170        180 
DGFPEPSQAK HPIDAITHYD SIDDRFYVFD LLNSPYGNVE EWSIEIAAKL QEQGGDEVPS 

       190        200        210        220        230        240 
EIIDKIIYMP FDNEKELLME YLNFWQQKTP VILTGWNVES FDIPYVYNRI KNIFGESTAK 

       250        260        270        280        290        300 
RLSPHRKTRV KVIENMYGSR EIITLFGISV LDYIDLYKKF SFTNQPSYSL DYISEFELNV 

       310        320        330        340        350        360 
GKLKYDGPIS KLRESNHQRY ISYNIIDVYR VLQIDAKRQF INLSLDMGYY AKIQIQSVFS 

       370        380        390        400        410        420 
PIKTWDAIIF NSLKEQNKVI PQGRSHPVQP YPGAFVKEPI PNRYKYVMSF DLTSLYPSII 

       430        440        450        460        470        480 
RQVNISPETI AGTFKVAPLH DYINAVAERP SDVYSCSPNG MMYYKDRDGV VPTEITKVFN 

       490        500        510        520        530        540 
QRKEHKGYML AAQRNGEIIK EALHNPNLSV DEPLDVDYRF DFSDEIKEKI KKLSAKSLNE 

       550        560        570        580        590        600 
MLFRAQRTEV AGMTAQINRK LLINSLYGAL GNVWFRYYDL RNATAITTFG QMALQWIERK 

       610        620        630        640        650        660 
VNEYLNEVCG TEGEAFVLYG DTDSIYVSAD KIIDKVGESK FRDTNHWVDF LDKFARERME 

       670        680        690        700        710        720 
PAIDRGFREM CEYMNNKQHL MFMDREAIAG PPLGSKGIGG FWTGKKRYAL NVWDMEGTRY 

       730        740        750        760        770        780 
AEPKLKIMGL ETQKSSTPKA VQKALKECIR RMLQEGEESL QEYFKEFEKE FRQLNYISIA 

       790        800        810        820        830        840 
SVSSANNIAK YDVGGFPGPK CPFHIRGILT YNRAIKGNID APQVVEGEKV YVLPLREGNP 

       850        860        870        880        890        900 
FGDKCIAWPS GTEITDLIKD DVLHWMDYTV LLEKTFIKPL EGFTSAAKLD YEKKASLFDM 


FDF 

« Hide

References

« Hide 'large scale' references
[1]"Modular organization of T4 DNA polymerase. Evidence from phylogenetics."
Wang C.C., Yeh L.-S., Karam J.D.
J. Biol. Chem. 270:26558-26564(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Enterobacteria phage RB69 complete genome."
Petrov V., Nolan J., Chin D., Letarov A., Krisch H.M., Karam J.D.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69."
Wang J., Sattar A.K., Wang C.C., Karam J.D., Konigsberg W.H., Steitz T.A.
Cell 89:1087-1099(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[4]"Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex."
Shamoo Y., Steitz T.A.
Cell 99:155-166(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF COMPLEX WITH GP45.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34036 Genomic DNA. Translation: AAA93077.1.
AY303349 Genomic DNA. Translation: AAP75958.1.
RefSeqNP_861746.1. NC_004928.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1B1Fmodel-R387-892[»]
1B8HX-ray3.00D893-903[»]
1CLQX-ray2.70A1-903[»]
1IG9X-ray2.60A1-903[»]
1IH7X-ray2.21A1-903[»]
1Q9XX-ray2.69A/B/C/D1-903[»]
1Q9YX-ray2.80A1-903[»]
1QE4model-F1-903[»]
1WAFX-ray3.20A/B1-903[»]
1WAGmodel-R1-903[»]
1WAHmodel-R1-903[»]
1WAImodel-R1-903[»]
1WAJX-ray2.80A1-903[»]
2ATQX-ray3.20A1-903[»]
2DTUX-ray2.37A/B/C/D1-902[»]
2DY4X-ray2.65A/B/C/D1-903[»]
2OYQX-ray2.86A/B/C/D1-903[»]
2OZMX-ray2.86A1-903[»]
2OZSX-ray2.75A1-903[»]
2P5GX-ray2.80A/B/C/D1-903[»]
2P5OX-ray2.80A/B/C/D1-903[»]
3CFOX-ray2.60A1-903[»]
3CFPX-ray2.50A1-903[»]
3CFRX-ray2.40A1-903[»]
3CQ8X-ray2.50A1-903[»]
3KD1X-ray2.66E1-903[»]
3KD5X-ray2.69E1-903[»]
3L8BX-ray2.15A/B1-903[»]
3LDSX-ray3.00A1-903[»]
3LZIX-ray2.30A1-903[»]
3LZJX-ray2.05A1-903[»]
3NAEX-ray2.00A1-903[»]
3NCIX-ray1.79A1-903[»]
3NDKX-ray2.00A1-903[»]
3NE6X-ray2.00A1-903[»]
3NGIX-ray1.89A1-903[»]
3NHGX-ray2.50A1-903[»]
3QEIX-ray2.18A1-903[»]
3QEPX-ray1.80A1-903[»]
3QERX-ray1.96A1-903[»]
3QESX-ray1.98A1-903[»]
3QETX-ray2.08A1-903[»]
3QEVX-ray1.77A1-903[»]
3QEWX-ray1.84A1-903[»]
3QEXX-ray1.73A1-903[»]
3QNNX-ray1.92A1-901[»]
3QNOX-ray1.88A1-901[»]
3RMAX-ray2.84A/B/C/D1-903[»]
3RMBX-ray2.65A/B/C/D1-903[»]
3RMCX-ray3.00A/B/C/D1-903[»]
3RMDX-ray2.98A/B/C/D1-903[»]
3RWUX-ray2.33A1-901[»]
3S9HX-ray1.95A1-903[»]
3SCXX-ray2.35A1-901[»]
3SI6X-ray1.85A1-901[»]
3SJJX-ray2.38A1-901[»]
3SNNX-ray2.00A1-901[»]
3SPYX-ray2.14A1-901[»]
3SPZX-ray2.43A1-903[»]
3SQ0X-ray2.00A1-903[»]
3SQ1X-ray1.82A1-901[»]
3SQ2X-ray2.10A1-902[»]
3SQ4X-ray2.23A1-902[»]
3SUNX-ray2.42A1-895[»]
3SUOX-ray2.23A1-900[»]
3SUPX-ray2.32A1-903[»]
3SUQX-ray3.15A1-897[»]
3TABX-ray2.80A/B/C/D1-903[»]
3TAEX-ray2.71A/B/C/D1-903[»]
3TAFX-ray3.00A/B/C/D1-903[»]
3TAGX-ray2.95A/B/C/D1-903[»]
3UIQX-ray1.88A1-903[»]
4DTJX-ray1.90A1-901[»]
4DTMX-ray1.95A1-901[»]
4DTNX-ray1.96A1-903[»]
4DTOX-ray2.05A1-903[»]
4DTPX-ray2.05A1-903[»]
4DTRX-ray2.04A1-903[»]
4DTSX-ray1.96A1-903[»]
4DTUX-ray1.86A1-903[»]
4DTXX-ray1.84A1-903[»]
4DU1X-ray2.15A1-903[»]
4DU3X-ray2.02A1-903[»]
4DU4X-ray2.28A1-903[»]
4E3SX-ray2.04A1-903[»]
4FJ5X-ray2.05A1-903[»]
4FJ7X-ray1.90A1-903[»]
4FJ8X-ray2.19A1-903[»]
4FJ9X-ray1.97A1-903[»]
4FJGX-ray2.02A1-903[»]
4FJHX-ray2.11A1-903[»]
4FJIX-ray2.20A1-903[»]
4FJJX-ray1.99A1-903[»]
4FJKX-ray2.00A1-903[»]
4FJLX-ray1.87A1-903[»]
4FJMX-ray2.02A1-903[»]
4FJNX-ray1.98A1-903[»]
4FJXX-ray2.11A1-903[»]
4FK0X-ray2.18A1-903[»]
4FK2X-ray1.98A1-903[»]
4FK4X-ray1.90A1-903[»]
4I9LX-ray2.60A1-903[»]
4I9QX-ray2.30A/B1-903[»]
4J2AX-ray1.80A1-901[»]
4J2BX-ray2.04A1-901[»]
4J2DX-ray1.76A1-901[»]
4J2EX-ray2.02A1-901[»]
4KHNX-ray2.55A/B1-903[»]
4KHQX-ray2.19A1-903[»]
4KHSX-ray2.12A1-903[»]
4KHUX-ray2.05A1-903[»]
4KHWX-ray2.37A1-903[»]
4KHYX-ray2.25A1-903[»]
4KI4X-ray2.45A1-903[»]
4KI6X-ray2.55A1-903[»]
4M3RX-ray2.07A1-903[»]
4M3TX-ray1.90A1-903[»]
4M3UX-ray2.07A1-903[»]
4M3WX-ray2.10A1-903[»]
4M3XX-ray2.20A1-903[»]
4M3YX-ray1.86A1-903[»]
4M3ZX-ray1.84A1-903[»]
4M41X-ray2.15A1-903[»]
4M42X-ray2.04A1-903[»]
4M45X-ray1.89A1-903[»]
ProteinModelPortalQ38087.
SMRQ38087. Positions 1-903.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1494172.

Enzyme and pathway databases

SABIO-RKQ38087.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
PRINTSPR00106. DNAPOLB.
SMARTSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
PROSITEPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ38087.

Entry information

Entry nameDPOL_BPR69
AccessionPrimary (citable) accession number: Q38087
Secondary accession number(s): Q76XX8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references