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Protein

DNA polymerase

Gene

5

Organism
Streptococcus phage Cp-1 (Bacteriophage Cp-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose.By similarity

Miscellaneous

This DNA polymerase requires a protein as a primer.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7, EC:3.1.11.-By similarity)
Gene namesi
Name:5
OrganismiStreptococcus phage Cp-1 (Bacteriophage Cp-1)
Taxonomic identifieri10747 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaeCp1virus
Virus hostiStreptococcus pneumoniae [TaxID: 1313]
Proteomesi
  • UP000009089 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465411 – 568DNA polymeraseAdd BLAST568

Interactioni

Protein-protein interaction databases

IntActiQ37989. 1 interactor.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Phylogenomic databases

KOiK21237.
OrthoDBiVOG0900004K.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 1 hit.
InterProiView protein in InterPro
IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR004868. DNA-dir_DNA_pol_B_mt/vir.
IPR014416. DNA-dir_DNA_polB_phi29_vir.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
PfamiView protein in Pfam
PF03175. DNA_pol_B_2. 1 hit.
PIRSFiPIRSF004178. Dpol_Bac_phage. 1 hit.
PRINTSiPR00106. DNAPOLB.
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS00116. DNA_POLYMERASE_B. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCYYAGDFE TTTNEEETEV WLSCFAKVID YDKLDTFKVN TSLEDFLKSL
60 70 80 90 100
YLDLDKTYTE TGEDEFIIFF HNLKFDGSFL LSFFLNNDIE CTYFINDMGV
110 120 130 140 150
WYSITLEFPD FTLTFRDSLK ILNFSIATMA GLFKMPIAKG TTPLLKHKPE
160 170 180 190 200
VIKPEWIDYI HVDVAILARG IFAMYYEENF TKYTSASEAL TEFKRIFRKS
210 220 230 240 250
KRKFRDFFPI LDEKVDDFCR KHIVGAGRLP TLKHRGRTLN QLIDIYDINS
260 270 280 290 300
MYPATMLQNA LPIGIPKRYK GKPKEIKEDH YYIYHIKADF DLKRGYLPTI
310 320 330 340 350
QIKKKLDALR IGVRTSDYVT TSKNEVIDLY LTNFDLDLFL KHYDATIMYV
360 370 380 390 400
ETLEFQTESD LFDDYITTYR YKKENAQSPA EKQKAKIMLN SLYGKFGAKI
410 420 430 440 450
ISVKKLAYLD DKGILRFKND DEEEVQPVYA PVALFVTSIA RHFIISNAQE
460 470 480 490 500
NYDNFLYADT DSLHLFHSDS LVLDIDPSEF GKWAHEGRAV KAKYLRSKLY
510 520 530 540 550
IEELIQEDGT THLDVKGAGM TPEIKEKITF ENFVIGATFE GKRASKQIKG
560
GTLIYETTFK IRETDYLV
Length:568
Mass (Da):66,149
Last modified:November 1, 1996 - v1
Checksum:i515F5EAEF1897896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47794 Genomic DNA. Translation: CAA87725.1.
PIRiS51275.
RefSeqiNP_044817.1. NC_001825.1.

Genome annotation databases

GeneIDi1261225.
KEGGivg:1261225.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDPOL_BPCP1
AccessioniPrimary (citable) accession number: Q37989
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families