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Protein

L-alanyl-D-glutamate peptidase

Gene

ply

Organism
Listeria phage A500 (Bacteriophage A500)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall lytic enzyme.

Catalytic activityi

Hydrolyzes the link between L-alanine and D-glutamate residues in certain bacterial cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

MEROPSiM15.021.

Names & Taxonomyi

Protein namesi
Recommended name:
L-alanyl-D-glutamate peptidase (EC:3.4.24.-)
Gene namesi
Name:ply
Synonyms:ply500
OrganismiListeria phage A500 (Bacteriophage A500)
Taxonomic identifieri40522 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
Virus hostiListeria monocytogenes [TaxID: 1639]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289L-alanyl-D-glutamate peptidasePRO_0000217836Add
BLAST

Expressioni

Developmental stagei

Expressed at about 20 minutes after infection.

Structurei

Secondary structure

1
289
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1612Combined sources
Helixi23 – 3715Combined sources
Turni38 – 403Combined sources
Beta strandi43 – 475Combined sources
Helixi52 – 609Combined sources
Turni61 – 633Combined sources
Beta strandi64 – 674Combined sources
Helixi79 – 824Combined sources
Beta strandi85 – 917Combined sources
Beta strandi95 – 995Combined sources
Beta strandi102 – 1043Combined sources
Helixi105 – 11612Combined sources
Helixi122 – 1243Combined sources
Beta strandi125 – 1284Combined sources
Beta strandi133 – 1375Combined sources
Helixi139 – 1413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VO9X-ray1.80A/B/C1-167[»]
ProteinModelPortaliQ37979.
SMRiQ37979. Positions 1-148, 155-289.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ37979.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M15C family.Curated

Phylogenomic databases

KOiK17733.

Family and domain databases

Gene3Di3.30.1380.10. 1 hit.
InterProiIPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
[Graphical view]
SUPFAMiSSF55166. SSF55166. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37979-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTEAWLIE KANRKLNAGG MYKITSDKTR NVIKKMAKEG IYLCVAQGYR
60 70 80 90 100
STAEQNALYA QGRTKPGAIV TNAKGGQSNH NYGVAVDLCL YTNDGKDVIW
110 120 130 140 150
ESTTSRWKKV VAAMKAEGFK WGGDWKSFKD YPHFELCDAV SGEKIPAATQ
160 170 180 190 200
NTNTNSNRYE GKVIDSAPLL PKMDFKSSPF RMYKVGTEFL VYDHNQYWYK
210 220 230 240 250
TYIDDKLYYM YKSFCDVVAK KDAKGRIKVR IKSAKDLRIP VWNNIKLNSG
260 270 280
KIKWYAPNVK LAWYNYRRGY LELWYPNDGW YYTAEYFLK
Length:289
Mass (Da):33,424
Last modified:November 1, 1996 - v1
Checksum:i1CD6B52B37260A6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85009 Genomic DNA. Translation: CAA59365.1.
PIRiS69801.
RefSeqiYP_001468411.1. NC_009810.1.

Genome annotation databases

GeneIDi5601386.
KEGGivg:5601386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85009 Genomic DNA. Translation: CAA59365.1.
PIRiS69801.
RefSeqiYP_001468411.1. NC_009810.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VO9X-ray1.80A/B/C1-167[»]
ProteinModelPortaliQ37979.
SMRiQ37979. Positions 1-148, 155-289.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM15.021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5601386.
KEGGivg:5601386.

Phylogenomic databases

KOiK17733.

Miscellaneous databases

EvolutionaryTraceiQ37979.

Family and domain databases

Gene3Di3.30.1380.10. 1 hit.
InterProiIPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
[Graphical view]
SUPFAMiSSF55166. SSF55166. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAEPE_BPA50
AccessioniPrimary (citable) accession number: Q37979
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.