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Q37896

- LYS_BPB03

UniProt

Q37896 - LYS_BPB03

Protein

Lysozyme

Gene

15

Organism
Bacillus phage B103 (Bacteriophage B103)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei15 – 151Proton donorBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiCBM50. Carbohydrate-Binding Module Family 50.
    GH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Lysis protein
    Morphogenesis protein 2
    Muramidase
    Gene namesi
    Name:15
    OrganismiBacillus phage B103 (Bacteriophage B103)
    Taxonomic identifieri10778 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaePhi29likevirus
    Virus hostiBacillus subtilis [TaxID: 1423]
    ProteomesiUP000000971: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263LysozymePRO_0000218092Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Structurei

    3D structure databases

    ProteinModelPortaliQ37896.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati165 – 20945LysM 1Add
    BLAST
    Repeati219 – 26345LysM 2Add
    BLAST

    Domaini

    LysM repeats are thought to be involved in peptidoglycan binding.

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated
    Contains 2 LysM repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    3.10.350.10. 2 hits.
    InterProiIPR002196. Glyco_hydro_24.
    IPR018392. LysM_dom.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF01476. LysM. 2 hits.
    PF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SMARTiSM00257. LysM. 2 hits.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    SSF54106. SSF54106. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q37896-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNISQAGINL IKSFEGLRTK AYKAVPTEKY YTIGYGHYGS DVHPCQVISE    50
    EKAEKLLRDD VQEFVDGVDK LLKVDVTQSQ FDALVSFAYN VGLGALKSST 100
    LLQYLNAGNF QKAANEFLKW NKSGGKVYNG LVKRREQERT LFLTGESKNV 150
    SRETSKPKTS KTNTHVVKKG DTLSEIAKKI KTSTKTLLEL NPTIKNPNKI 200
    YVGQRINVGG SPVKSTLKYK IKRGETLTGI AKKNKTTVSQ LMKLNPNIKN 250
    ANNIYAGQTI RLK 263
    Length:263
    Mass (Da):29,264
    Last modified:November 1, 1996 - v1
    Checksum:i5C1A7C8282A1DBCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99260 Genomic DNA. Translation: CAA67646.1.
    RefSeqiNP_690649.1. NC_004165.1.

    Genome annotation databases

    GeneIDi955364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99260 Genomic DNA. Translation: CAA67646.1 .
    RefSeqi NP_690649.1. NC_004165.1.

    3D structure databases

    ProteinModelPortali Q37896.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM50. Carbohydrate-Binding Module Family 50.
    GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 955364.

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    3.10.350.10. 2 hits.
    InterProi IPR002196. Glyco_hydro_24.
    IPR018392. LysM_dom.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF01476. LysM. 2 hits.
    PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SMARTi SM00257. LysM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    SSF54106. SSF54106. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Bacteriophage B103: complete DNA sequence of its genome and relationship to other Bacillus phages."
      Pecenkova T., Benes V., Paces J., Vlcek C., Paces V.
      Gene 199:157-163(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiLYS_BPB03
    AccessioniPrimary (citable) accession number: Q37896
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3