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Q37896

- LYS_BPB03

UniProt

Q37896 - LYS_BPB03

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Protein
Lysozyme
Gene
15
Organism
Bacillus phage B103 (Bacteriophage B103)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151Proton donor By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.
GH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Morphogenesis protein 2
Muramidase
Gene namesi
Name:15
OrganismiBacillus phage B103 (Bacteriophage B103)
Taxonomic identifieri10778 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaePicovirinaePhi29likevirus
Virus hostiBacillus subtilis [TaxID: 1423]
ProteomesiUP000000971: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Lysozyme
PRO_0000218092Add
BLAST

Expressioni

Keywords - Developmental stagei

Late protein

Structurei

3D structure databases

ProteinModelPortaliQ37896.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati165 – 20945LysM 1
Add
BLAST
Repeati219 – 26345LysM 2
Add
BLAST

Domaini

LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Contains 2 LysM repeats.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
3.10.350.10. 2 hits.
InterProiIPR002196. Glyco_hydro_24.
IPR018392. LysM_dom.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF01476. LysM. 2 hits.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 2 hits.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF54106. SSF54106. 2 hits.

Sequencei

Sequence statusi: Complete.

Q37896-1 [UniParc]FASTAAdd to Basket

« Hide

MNISQAGINL IKSFEGLRTK AYKAVPTEKY YTIGYGHYGS DVHPCQVISE    50
EKAEKLLRDD VQEFVDGVDK LLKVDVTQSQ FDALVSFAYN VGLGALKSST 100
LLQYLNAGNF QKAANEFLKW NKSGGKVYNG LVKRREQERT LFLTGESKNV 150
SRETSKPKTS KTNTHVVKKG DTLSEIAKKI KTSTKTLLEL NPTIKNPNKI 200
YVGQRINVGG SPVKSTLKYK IKRGETLTGI AKKNKTTVSQ LMKLNPNIKN 250
ANNIYAGQTI RLK 263
Length:263
Mass (Da):29,264
Last modified:November 1, 1996 - v1
Checksum:i5C1A7C8282A1DBCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99260 Genomic DNA. Translation: CAA67646.1.
RefSeqiNP_690649.1. NC_004165.1.

Genome annotation databases

GeneIDi955364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99260 Genomic DNA. Translation: CAA67646.1 .
RefSeqi NP_690649.1. NC_004165.1.

3D structure databases

ProteinModelPortali Q37896.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi CBM50. Carbohydrate-Binding Module Family 50.
GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 955364.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
3.10.350.10. 2 hits.
InterProi IPR002196. Glyco_hydro_24.
IPR018392. LysM_dom.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF01476. LysM. 2 hits.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SMARTi SM00257. LysM. 2 hits.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
SSF54106. SSF54106. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Bacteriophage B103: complete DNA sequence of its genome and relationship to other Bacillus phages."
    Pecenkova T., Benes V., Paces J., Vlcek C., Paces V.
    Gene 199:157-163(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPB03
AccessioniPrimary (citable) accession number: Q37896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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