Q37896 (LYS_BPB03) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme
EC=3.2.1.17

Alternative name(s):
Endolysin
Lysis protein
Morphogenesis protein 2
Muramidase

Gene names

Name:

15

Organism

Bacillus phage B103 (Bacteriophage B103) [Complete proteome]

Taxonomic identifier

10778 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Podoviridae › Picovirinae › Phi29likevirus

Virus host

Bacillus subtilis [TaxID: 1423]

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan By similarity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Domain	LysM repeats are thought to be involved in peptidoglycan binding.
Sequence similarities	Belongs to the glycosyl hydrolase 24 family. Contains 2 LysM repeats.

Ontologies

Keywords
Developmental stage	Late protein
Domain	Repeat
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Lysozyme		PRO_0000218092
Regions
	Repeat	165 – 209	45	LysM 1
	Repeat	219 – 263	45	LysM 2
Sites
	Active site	15	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q37896 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5C1A7C8282A1DBCE	FASTA	263	29,264
	10 20 30 40 50 60 MNISQAGINL IKSFEGLRTK AYKAVPTEKY YTIGYGHYGS DVHPCQVISE EKAEKLLRDD 70 80 90 100 110 120 VQEFVDGVDK LLKVDVTQSQ FDALVSFAYN VGLGALKSST LLQYLNAGNF QKAANEFLKW 130 140 150 160 170 180 NKSGGKVYNG LVKRREQERT LFLTGESKNV SRETSKPKTS KTNTHVVKKG DTLSEIAKKI 190 200 210 220 230 240 KTSTKTLLEL NPTIKNPNKI YVGQRINVGG SPVKSTLKYK IKRGETLTGI AKKNKTTVSQ 250 260 LMKLNPNIKN ANNIYAGQTI RLK

References

[1]	"Bacteriophage B103: complete DNA sequence of its genome and relationship to other Bacillus phages." Pecenkova T., Benes V., Paces J., Vlcek C., Paces V. Gene 199:157-163(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99260 Genomic DNA. Translation: CAA67646.1.
RefSeq	NP_690649.1. NC_004165.1.
3D structure databases
ProteinModelPortal	Q37896.
ModBase	Search...
Protein family/group databases
CAZy	CBM50. Carbohydrate-Binding Module Family 50. GH24. Glycoside Hydrolase Family 24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	955364.
Phylogenomic databases
ProtClustDB	CLSP2343229.
Family and domain databases
Gene3D	1.10.530.40. 1 hit.
InterPro	IPR002196. Glyco_hydro_24. IPR023346. Lysozyme-like_dom. IPR023347. Lysozyme_dom. IPR018392. Peptidoglycan-bd_lysin. IPR002482. Peptidoglycan-bd_Lysin_subgr. [Graphical view]
Pfam	PF01476. LysM. 2 hits. PF00959. Phage_lysozyme. 1 hit. [Graphical view]
SMART	SM00257. LysM. 2 hits. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYS_BPB03

Accession

Primary (citable) accession number: Q37896

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program