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Q37875

- LYS_BPP1

UniProt

Q37875 - LYS_BPP1

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Protein
Lysozyme
Gene
17, lysa, lyz
Organism
Enterobacteria phage P1 (Bacteriophage P1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421Proton donor By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
Protein gp17
Gene namesi
Name:17
Synonyms:lysa, lyz
OrganismiEnterobacteria phage P1 (Bacteriophage P1)
Taxonomic identifieri10678 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePunalikevirus
Virus hostiEnterobacteriaceae [TaxID: 543]
ProteomesiUP000008091: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Lysozyme
PRO_0000218099Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 2511
Helixi32 – 387
Helixi41 – 466
Helixi48 – 503
Helixi53 – 553
Beta strandi56 – 594
Helixi74 – 9522
Helixi98 – 1003
Helixi103 – 11614
Helixi118 – 1225
Beta strandi123 – 1264
Turni127 – 1304
Beta strandi131 – 1344
Helixi136 – 1427
Helixi146 – 1516
Helixi152 – 1554
Helixi165 – 17915
Turni180 – 1823

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XJTX-ray1.75A1-185[»]
1XJUX-ray1.07A/B29-185[»]
ProteinModelPortaliQ37875.
SMRiQ37875. Positions 9-185.

Miscellaneous databases

EvolutionaryTraceiQ37875.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37875-1 [UniParc]FASTAAdd to Basket

« Hide

MKGKTAAGGG AICAIAVMIT IVMGNGNVRT NQAGLELIGN AEGCRRDPYM    50
CPAGVWTDGI GNTHGVTPGV RKTDQQIAAD WEKNILIAER CINQHFRGKD 100
MPDNAFSAMT SAAFNMGCNS LRTYYSKARG MRVETSIHKW AQKGEWVNMC 150
NHLPDFVNSN GVPLRGLKIR REKERQLCLT GLVNE 185
Length:185
Mass (Da):20,256
Last modified:November 1, 1996 - v1
Checksum:i8F7CA469850049B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87673 Genomic DNA. Translation: CAA61013.1.
AF125376 Genomic DNA. Translation: AAD20630.1.
AF234172 Genomic DNA. Translation: AAQ13989.1.
RefSeqiYP_006484.1. NC_005856.1.

Genome annotation databases

GeneIDi2777454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87673 Genomic DNA. Translation: CAA61013.1 .
AF125376 Genomic DNA. Translation: AAD20630.1 .
AF234172 Genomic DNA. Translation: AAQ13989.1 .
RefSeqi YP_006484.1. NC_005856.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XJT X-ray 1.75 A 1-185 [» ]
1XJU X-ray 1.07 A/B 29-185 [» ]
ProteinModelPortali Q37875.
SMRi Q37875. Positions 9-185.
ModBasei Search...

Protein family/group databases

CAZyi GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2777454.

Miscellaneous databases

EvolutionaryTracei Q37875.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three functions of bacteriophage P1 involved in cell lysis."
    Schmidt C., Velleman M., Arber W.
    J. Bacteriol. 178:1099-1104(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Lehnherr H., Bendtsen J.D., Preuss F., Ilyina T.V.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPP1
AccessioniPrimary (citable) accession number: Q37875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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