Q37875 (LYS_BPP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme
EC=3.2.1.17

Alternative name(s):
Endolysin
Lysis protein
Muramidase
Protein gp17

Gene names

Name:	17
Synonyms:	lysa, lyz

Organism

Enterobacteria phage P1 (Bacteriophage P1) [Reference proteome]

Taxonomic identifier

10678 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Myoviridae › Punalikevirus

Virus host

Enterobacteriaceae [TaxID: 543]

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 24 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 185

185

Lysozyme

PRO_0000218099

Sites

Active site

42

1

Proton donor By similarity

Secondary structure

1

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185

Helix Strand Turn

Details...

Helix

15 – 25

11

Helix

32 – 38

7

Helix

41 – 46

6

Helix

48 – 50

3

Helix

53 – 55

3

Beta strand

56 – 59

4

Helix

74 – 95

22

Helix

98 – 100

3

Helix

103 – 116

14

Helix

118 – 122

5

Beta strand

123 – 126

4

Turn

127 – 130

4

Beta strand

131 – 134

4

Helix

136 – 142

7

Helix

146 – 151

6

Helix

152 – 155

4

Helix

165 – 179

15

Turn

180 – 182

3

Sequences

	Sequence		Length	Mass (Da)
	Q37875 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8F7CA469850049B2	FASTA	185	20,256
	10 20 30 40 50 60 MKGKTAAGGG AICAIAVMIT IVMGNGNVRT NQAGLELIGN AEGCRRDPYM CPAGVWTDGI 70 80 90 100 110 120 GNTHGVTPGV RKTDQQIAAD WEKNILIAER CINQHFRGKD MPDNAFSAMT SAAFNMGCNS 130 140 150 160 170 180 LRTYYSKARG MRVETSIHKW AQKGEWVNMC NHLPDFVNSN GVPLRGLKIR REKERQLCLT GLVNE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three functions of bacteriophage P1 involved in cell lysis." Schmidt C., Velleman M., Arber W. J. Bacteriol. 178:1099-1104(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Lehnherr H., Bendtsen J.D., Preuss F., Ilyina T.V. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genome of bacteriophage P1." Lobocka M.B., Rose D.J., Plunkett G. III, Rusin M., Samojedny A., Lehnherr H., Yarmolinsky M.B., Blattner F.R. J. Bacteriol. 186:7032-7068(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X87673 Genomic DNA. Translation: CAA61013.1.
AF125376 Genomic DNA. Translation: AAD20630.1.
AF234172 Genomic DNA. Translation: AAQ13989.1.

RefSeq

YP_006484.1. NC_005856.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XJT	X-ray	1.75	A	1-185	[»]
1XJU	X-ray	1.07	A/B	29-185	[»]

ProteinModelPortal

Q37875.

SMR

Q37875. Positions 9-185.

ModBase

Search...

Protein family/group databases

CAZy

GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

2777454.

Phylogenomic databases

ProtClustDB

CLSP2343231.

Family and domain databases

Gene3D

1.10.530.40. 1 hit.

InterPro

IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]

Pfam

PF00959. Phage_lysozyme. 1 hit.
[Graphical view]

SUPFAM

SSF53955. SSF53955. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q37875.

Entry information

Entry name

LYS_BPP1

Accession

Primary (citable) accession number: Q37875

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program