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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation
Gene namesi
Name:COIIImported
Synonyms:CO2Imported, COX2Imported
Encoded oniMitochondrionImported
OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)Imported
Taxonomic identifieri9597 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

  • Mitochondrion inner membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91COX2_TMInterPro annotationAdd BLAST91
Domaini92 – 225COX2_CUAInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAAQVGLQ DATSPIMEEL IIFHDHALMI IFLICFLVLY ALFLTLTTKL
60 70 80 90 100
TNTSISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSFTIKSI
110 120 130 140 150
GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPVEAPV
160 170 180 190 200
RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC
210 220
GANHSFMPIV LELIPLKIFE MGPVFAL
Length:227
Mass (Da):25,526
Last modified:November 1, 1996 - v1
Checksum:iB3892588473C7BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12696 Genomic DNA. Translation: AAA20849.1.
U12702 Genomic DNA. Translation: AAA61411.1.
GU189657 Genomic DNA. Translation: ADA55500.1.
GU189658 Genomic DNA. Translation: ADA55513.1.
GU189660 Genomic DNA. Translation: ADA55539.1.
GU189662 Genomic DNA. Translation: ADA55565.1.
GU189663 Genomic DNA. Translation: ADA55578.1.
GU189664 Genomic DNA. Translation: ADA55591.1.
GU189667 Genomic DNA. Translation: ADA55630.1.
GU189671 Genomic DNA. Translation: ADA55682.1.
GU189676 Genomic DNA. Translation: ADA55747.1.
GU189677 Genomic DNA. Translation: ADA55760.1.
HM015213 Genomic DNA. Translation: ADE05929.1.
JN191188 Genomic DNA. Translation: AEO20423.1.
JN191189 Genomic DNA. Translation: AEO20436.1.
JN191194 Genomic DNA. Translation: AEO20501.1.
JN191197 Genomic DNA. Translation: AEO20540.1.
JF727223 Genomic DNA. Translation: AEQ36379.1.
JF727224 Genomic DNA. Translation: AEQ36392.1.
JF727225 Genomic DNA. Translation: AEQ36404.1.
JF727226 Genomic DNA. Translation: AEQ36417.1.
JF727227 Genomic DNA. Translation: AEQ36429.1.
JF727228 Genomic DNA. Translation: AEQ36441.1.
JF727229 Genomic DNA. Translation: AEQ36454.1.
JF727230 Genomic DNA. Translation: AEQ36467.1.
JF727231 Genomic DNA. Translation: AEQ36480.1.
JF727232 Genomic DNA. Translation: AEQ36492.1.
JF727233 Genomic DNA. Translation: AEQ36503.1.
JF727234 Genomic DNA. Translation: AEQ36516.1.
JF727235 Genomic DNA. Translation: AEQ36529.1.
JF727236 Genomic DNA. Translation: AEQ36542.1.
JF727237 Genomic DNA. Translation: AEQ36555.1.
JF727238 Genomic DNA. Translation: AEQ36568.1.
KX211928 Genomic DNA. Translation: ANP95472.1.
KX211929 Genomic DNA. Translation: ANP95485.1.
KX211933 Genomic DNA. Translation: ANP95537.1.
KX211935 Genomic DNA. Translation: ANP95563.1.
KX211937 Genomic DNA. Translation: ANP95589.1.
PIRiI84443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12696 Genomic DNA. Translation: AAA20849.1.
U12702 Genomic DNA. Translation: AAA61411.1.
GU189657 Genomic DNA. Translation: ADA55500.1.
GU189658 Genomic DNA. Translation: ADA55513.1.
GU189660 Genomic DNA. Translation: ADA55539.1.
GU189662 Genomic DNA. Translation: ADA55565.1.
GU189663 Genomic DNA. Translation: ADA55578.1.
GU189664 Genomic DNA. Translation: ADA55591.1.
GU189667 Genomic DNA. Translation: ADA55630.1.
GU189671 Genomic DNA. Translation: ADA55682.1.
GU189676 Genomic DNA. Translation: ADA55747.1.
GU189677 Genomic DNA. Translation: ADA55760.1.
HM015213 Genomic DNA. Translation: ADE05929.1.
JN191188 Genomic DNA. Translation: AEO20423.1.
JN191189 Genomic DNA. Translation: AEO20436.1.
JN191194 Genomic DNA. Translation: AEO20501.1.
JN191197 Genomic DNA. Translation: AEO20540.1.
JF727223 Genomic DNA. Translation: AEQ36379.1.
JF727224 Genomic DNA. Translation: AEQ36392.1.
JF727225 Genomic DNA. Translation: AEQ36404.1.
JF727226 Genomic DNA. Translation: AEQ36417.1.
JF727227 Genomic DNA. Translation: AEQ36429.1.
JF727228 Genomic DNA. Translation: AEQ36441.1.
JF727229 Genomic DNA. Translation: AEQ36454.1.
JF727230 Genomic DNA. Translation: AEQ36467.1.
JF727231 Genomic DNA. Translation: AEQ36480.1.
JF727232 Genomic DNA. Translation: AEQ36492.1.
JF727233 Genomic DNA. Translation: AEQ36503.1.
JF727234 Genomic DNA. Translation: AEQ36516.1.
JF727235 Genomic DNA. Translation: AEQ36529.1.
JF727236 Genomic DNA. Translation: AEQ36542.1.
JF727237 Genomic DNA. Translation: AEQ36555.1.
JF727238 Genomic DNA. Translation: AEQ36568.1.
KX211928 Genomic DNA. Translation: ANP95472.1.
KX211929 Genomic DNA. Translation: ANP95485.1.
KX211933 Genomic DNA. Translation: ANP95537.1.
KX211935 Genomic DNA. Translation: ANP95563.1.
KX211937 Genomic DNA. Translation: ANP95589.1.
PIRiI84443.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ37756_PANPA
AccessioniPrimary (citable) accession number: Q37756
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.