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Protein

Phosphoglycerate kinase

Gene

cPGK-8

Organism
Trypanosoma brucei
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (p56), Phosphoglycerate kinase, Phosphoglycerate kinase (cPGK-8)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Binding sitei223ATPUniRule annotation1
Binding sitei345ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 378ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:cPGK-8Imported
Encoded oniMitochondrionImported
OrganismiTrypanosoma bruceiImported
Taxonomic identifieri5691 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Proteomic databases

PaxDbiQ37744.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ37744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1367. Eukaryota.
COG0126. LUCA.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 2 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
IPR036043. Phosphoglycerate_kinase_sf.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKERKSIN ECDLKGKKVL IRVDFNVPLD DGNITNDYRI RSALPAVQKV
60 70 80 90 100
LTEGGSCVLM SHLGRPKGVS MAEGKELRSA GGIPGFEQKA TLKPVAKRLS
110 120 130 140 150
ELLSRPVTFA PDCLNAADVV SKMSPGDVVL LENVRFYKEE GSKSTEEREA
160 170 180 190 200
MAKILASYGD VYISDAFGTA HRDSATMTGI PKILGHGAAG YLMEKEISYF
210 220 230 240 250
AKVLGNPPRP LVAIVGGAKV SEKIQLLDNM LQRIDYLLIG GAMAYTFLKA
260 270 280 290 300
QGYSIGKSKC EESKLEFARS LLKKAEDRKV QVILPIDHVC HTEFKAVDSP
310 320 330 340 350
LITEDQNIPE GHMALDIGPK TIEKYVQTIG KCKSAIWNGP MGVFEMVPYS
360 370 380 390 400
KGTFAIAKAM GRGTHEHGLM SIIGGGDSAS AAELSGEAKR MSHVSTGGGA
410 420
SLELLEGKTL PGVTVLDEKE
Length:420
Mass (Da):45,243
Last modified:November 1, 1996 - v1
Checksum:i447D5DEB5643F146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33775 Genomic DNA. Translation: AAA32120.1.

Similar proteinsi

Entry informationi

Entry nameiQ37744_9TRYP
AccessioniPrimary (citable) accession number: Q37744
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)