p56

Functionⁱ

Catalytic activityⁱ

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

no protein annotated in this organism
Phosphoglycerate kinase (p56), Phosphoglycerate kinase, Phosphoglycerate kinase (cPGK-8)
no protein annotated in this organism
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functionⁱ

phosphoglycerate kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	KinaseUniRule annotation, Transferase

Molecular function

KinaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00185.

UniPathwayⁱ

UPA00109; UER00185.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesⁱ	Name:p56Imported
Encoded onⁱ	MitochondrionImported
Organismⁱ	Trypanosoma bruceiImported
Taxonomic identifierⁱ	5691 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Trypanozoon

Subcellular locationⁱ

GO - Cellular componentⁱ

mitochondrion Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

MitochondrionImported

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q37743.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	347 – 367	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the phosphoglycerate kinase family.UniRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1367. Eukaryota. COG0126. LUCA.

eggNOGⁱ

KOG1367. Eukaryota.
COG0126. LUCA.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Dⁱ	3.40.50.1260. 3 hits.
HAMAPⁱ	MF_00145. Phosphoglyc_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR001576. Phosphoglycerate_kinase. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00111. PGLYCERATE_KINASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q37743-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTAPNAKNN ISLKKSVGDV WPLTGKRVLM RVDFNVPMQN GHITNDYRIR 
        60         70         80         90        100
AAIPTIRRVI DQGGICILLS HLGRPRGVSM VAGVRDIRRR YHEAQFHDNK 
       110        120        130        140        150
GKTAFFSVLP GEEKVKILAK SSAREEATHI SPEVKSGKTM LFARLPEDEK 
       160        170        180        190        200
KSLLMQYLNE NKDSALPQMS VSAGYEEQYR SRPVAVRLAE LLGQHVYFAH 
       210        220        230        240        250
DCLDARVEVS RLKRGNVMLL ENVRFYSEEN GENAEEREAM AKILASYGDV 
       260        270        280        290        300
YISDAFGAAH RDSATMTGIP KILGHGAAGY LMEKEISYFA KVLGNPPRPL 
       310        320        330        340        350
VAIVGGAKVS EKIQLLDNML QRIDYLLIGG AMAYTFLKAQ GYSIGISKCE 
       360        370        380        390        400
ESKLEFARSL LKKAEDRKVQ VILPIDHVCH TEFKAVDSPL ITEDQNIPEG 
       410        420        430        440        450
HMALDIGPKT IEKYVQTIGK CKSAIWNGPM GVFEMVPYSK GTFAIAKAMG 
       460        470        480        490        500
RGTQKRGLMS IIGGGESAGA AELCGEAARI SHVSTGGGAS LELLEGKTLP 

GVAVLDDKE

Length:509

Mass (Da):55,747

Last modified:November 1, 1996 - v1

Checksum:ⁱ8F5CD49EAC57D75A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37784 Genomic DNA. Translation: AAA32119.1.
PIRⁱ	A45593.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q37743	P08892 A0A1G4I0F1 Q4GZE6 C9ZHV0 P08891	Trypanosoma brucei brucei Trypanosoma equiperdum Trypanosoma brucei brucei (strain 927/4 GUTat10.1) Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	508	UniRef90_P08892	Cluster: Phosphoglycerate kinase A	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q37743	P08966 A0A0N0P4S0 A4HBH9 A0A088S8I8 A0A1E1IVI7 A0A0S4JE17 A0A1X0NWU8 V5BAG7 Q4D192 Q95PK9 +35	Crithidia fasciculata Leptomonas seymouri Leishmania braziliensis Leishmania panamensis Leishmania guyanensis Bodo saltans (Flagellated protozoan) Trypanosoma theileri Trypanosoma cruzi Dm28c Trypanosoma cruzi (strain CL Brener) Trypanosoma cruzi And more	417	UniRef50_P08966	Cluster: Phosphoglycerate kinase, cytosolic	46

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M37784 Genomic DNA. Translation: AAA32119.1.
PIRⁱ	A45593.

3D structure databases

ProteinModelPortalⁱ	Q37743.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG1367. Eukaryota. COG0126. LUCA.

eggNOGⁱ

KOG1367. Eukaryota.
COG0126. LUCA.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00185.

UniPathwayⁱ

UPA00109; UER00185.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Dⁱ	3.40.50.1260. 3 hits.
HAMAPⁱ	MF_00145. Phosphoglyc_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR001576. Phosphoglycerate_kinase. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. IPR036043. Phosphoglycerate_kinase_sf.
PANTHERⁱ	PTHR11406. PTHR11406. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00162. PGK. 1 hit.
PRINTSⁱ	PR00477. PHGLYCKINASE.
SUPFAMⁱ	SSF53748. SSF53748. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00111. PGLYCERATE_KINASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q37743_9TRYP
Accessionⁱ	Q37743Primary (citable) accession number: Q37743
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 1, 1996
	Last sequence update:	November 1, 1996
	Last modified:	February 28, 2018
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q37743 (Q37743_9TRYP)

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Phosphoglycerate kinase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Coiled coil

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q37743 (Q37743_9TRYP)

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Phosphoglycerate kinase

p56

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ