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Q37741

- COX2_GADMO

UniProt

Q37741 - COX2_GADMO

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Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ACurated
Metal bindingi196 – 1961Copper ACurated
Metal bindingi200 – 2001Copper ACurated
Metal bindingi204 – 2041Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded oniMitochondrion
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4822HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST
Topological domaini83 – 230148Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Cytochrome c oxidase subunit 2PRO_0000183597Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ37741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37741-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VFLISTLVLY IIVAMVSTKL
60 70 80 90 100
TNKYILDSQE IEIIWTVLPA VILILIALPS LRILYLMDEI NDPHLTIKAM
110 120 130 140 150
GHQWYWSYEY TDYEDLGFDS YMIPTQDLAP GQFRLLEADH RMVVPVESPI
160 170 180 190 200
RILISAEDVL HSWAVPALGI KMDAVPGRLN QTAFITSRPG VFYGQCSEIC
210 220 230
GANHSFMPIV VEAVPLEHFE SWSSLMLEDA
Length:230
Mass (Da):26,013
Last modified:November 1, 1997 - v1
Checksum:iE5B1FAF71146BE8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76364 Genomic DNA. Translation: CAA53966.1. Different termination.
X99772 Genomic DNA. No translation available.
RefSeqiNP_008616.2. NC_002081.1.

Genome annotation databases

GeneIDi808446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76364 Genomic DNA. Translation: CAA53966.1 . Different termination.
X99772 Genomic DNA. No translation available.
RefSeqi NP_008616.2. NC_002081.1.

3D structure databases

ProteinModelPortali Q37741.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808446.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

HOVERGENi HBG012727.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of 12 structural genes and a novel non-coding region from mitochondrial DNA of Atlantic cod, Gadus morhua."
    Johansen S., Johansen T.
    Biochim. Biophys. Acta 1218:213-217(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Norwegian coastal 1.
  2. "The complete mitochondrial DNA sequence of Atlantic cod (Gadus morhua): relevance to taxonomic studies among codfishes."
    Johansen S., Bakke I.
    Mol. Mar. Biol. Biotechnol. 5:203-214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Norwegian coastal 1.

Entry informationi

Entry nameiCOX2_GADMO
AccessioniPrimary (citable) accession number: Q37741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3