Reviewed, UniProtKB/Swiss-Prot Q37720 (NDUS2_PYLLI)

Names and origin

Protein names

Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH dehydrogenase subunit 7

Gene names

Name:

NAD7

Encoded on

Mitochondrion

Organism

Pylaiella littoralis

Taxonomic identifier

2885 [NCBI]

Taxonomic lineage

Eukaryota › stramenopiles › PX clade › Phaeophyceae › Ectocarpales › Acinetosporaceae › Pylaiella

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	NADH-ubiquinone oxidoreductase 49 kDa subunit		PRO_0000118592

Sequences

	Sequence		Length	Mass (Da)
	Q37720-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D3C46D2B7CA33FF6	FASTA	398	45,245
	10 20 30 40 50 60 MALKKKEFNK KLKHFTINFG PQHPAAHGVL RLILELNGEV VQRADPHIGL LHRGTEKLIE 70 80 90 100 110 120 AKTYFQALPY FDRLDYVSMM CQEHTYALSV ENLLQVSIPR RAQFIRVLFA EITRILNHLL 130 140 150 160 170 180 AVGCHAMDVG AMTPFLWAFE EREKLMEFYE RVSGARMHAS YFRPGGVSQD ISVGLVDDIF 190 200 210 220 230 240 AFVAQFGQRL DEIEEMLTDN RIWQERLVDI GVVSAQEAID WGFSGVMLRG SGIRWDLRKN 250 260 270 280 290 300 EPYEIYSDLN FQGVVGKTGD CYDRYLARVE EMRQSLSIIY QCLNKMPRGS VKIDDAKISP 310 320 330 340 350 360 PSRSEVKQSM ESLIHHFKLY TEGVFVPAGE TYTATEAPKG EFGVYLVSKG SSRPYRCKIK 370 380 390 APGFSHLQGL NFMACSHMLA DVVTIIGTQD IVFGEVDR

References

[1]	"Characterisation of the cox3, nad7 and atp6 genes from the mitochondrial genome of the brown alga Pylaiella littoralis." Fontaine J.-M., Rousvoal S., Delaroque N., Loiseaux-De Goer S. Plant Physiol. Biochem. 33:605-609(1995) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48623 Genomic DNA. Translation: CAA88557.1.
PIR	S53054.
RefSeq	NP_150429.1.
3D structure databases
SMR	Q37720. Positions 24-398.
ModBase	Search...
Genome annotation databases
GeneID	803753.
Enzyme and pathway databases
BRENDA	1.6.5.3. 291284. 1.6.99.3. 291284.
Family and domain databases
InterPro	IPR010219. NADH_DH_1_dsu. IPR001135. NADH_Q_OxRdtase_suD. IPR014029. NADH_UbQ_OxRdtase_49kDa_CS. [Graphical view]
Pfam	PF00346. Complex1_49kDa. 1 hit. [Graphical view]
TIGRFAMs	TIGR01962. NuoD. 1 hit.
PROSITE	PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS2_PYLLI

Accession

Primary (citable) accession number: Q37720

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)