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Q37720 (NDUS2_PYLLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH dehydrogenase subunit 7
Gene names
Name:NAD7
Encoded onMitochondrion
OrganismPylaiella littoralis
Taxonomic identifier2885 [NCBI]
Taxonomic lineageEukaryotaStramenopilesPX cladePhaeophyceaeEctocarpalesAcinetosporaceaePylaiella

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme. HAMAP-Rule MF_01358

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01358

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01358

Subcellular location

Mitochondrion HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMitochondrion
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398NADH-ubiquinone oxidoreductase 49 kDa subunit HAMAP-Rule MF_01358
PRO_0000118592

Sequences

Sequence LengthMass (Da)Tools
Q37720 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D3C46D2B7CA33FF6

FASTA39845,245
        10         20         30         40         50         60 
MALKKKEFNK KLKHFTINFG PQHPAAHGVL RLILELNGEV VQRADPHIGL LHRGTEKLIE 

        70         80         90        100        110        120 
AKTYFQALPY FDRLDYVSMM CQEHTYALSV ENLLQVSIPR RAQFIRVLFA EITRILNHLL 

       130        140        150        160        170        180 
AVGCHAMDVG AMTPFLWAFE EREKLMEFYE RVSGARMHAS YFRPGGVSQD ISVGLVDDIF 

       190        200        210        220        230        240 
AFVAQFGQRL DEIEEMLTDN RIWQERLVDI GVVSAQEAID WGFSGVMLRG SGIRWDLRKN 

       250        260        270        280        290        300 
EPYEIYSDLN FQGVVGKTGD CYDRYLARVE EMRQSLSIIY QCLNKMPRGS VKIDDAKISP 

       310        320        330        340        350        360 
PSRSEVKQSM ESLIHHFKLY TEGVFVPAGE TYTATEAPKG EFGVYLVSKG SSRPYRCKIK 

       370        380        390 
APGFSHLQGL NFMACSHMLA DVVTIIGTQD IVFGEVDR 

« Hide

References

[1]"Characterisation of the cox3, nad7 and atp6 genes from the mitochondrial genome of the brown alga Pylaiella littoralis."
Fontaine J.-M., Rousvoal S., Delaroque N., Loiseaux-De Goer S.
Plant Physiol. Biochem. 33:605-609(1995)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48623 Genomic DNA. Translation: CAA88557.1.
PIRS53054.
RefSeqNP_150429.1. NC_003055.1.

3D structure databases

ProteinModelPortalQ37720.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID803753.

Family and domain databases

Gene3D1.10.645.10. 2 hits.
HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMSSF56762. SSF56762. 1 hit.
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_PYLLI
AccessionPrimary (citable) accession number: Q37720
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families