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Q37720

- NDUS2_PYLLI

UniProt

Q37720 - NDUS2_PYLLI

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Protein
NADH-ubiquinone oxidoreductase 49 kDa subunit
Gene
NAD7
Organism
Pylaiella littoralis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.UniRule annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation
NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  3. quinone binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:NAD7
    Encoded oniMitochondrion
    OrganismiPylaiella littoralis
    Taxonomic identifieri2885 [NCBI]
    Taxonomic lineageiEukaryotaStramenopilesPX cladePhaeophyceaeEctocarpalesAcinetosporaceaePylaiella

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398NADH-ubiquinone oxidoreductase 49 kDa subunitUniRule annotation
    PRO_0000118592Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ37720.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.645.10. 2 hits.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q37720-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKKKEFNK KLKHFTINFG PQHPAAHGVL RLILELNGEV VQRADPHIGL    50
    LHRGTEKLIE AKTYFQALPY FDRLDYVSMM CQEHTYALSV ENLLQVSIPR 100
    RAQFIRVLFA EITRILNHLL AVGCHAMDVG AMTPFLWAFE EREKLMEFYE 150
    RVSGARMHAS YFRPGGVSQD ISVGLVDDIF AFVAQFGQRL DEIEEMLTDN 200
    RIWQERLVDI GVVSAQEAID WGFSGVMLRG SGIRWDLRKN EPYEIYSDLN 250
    FQGVVGKTGD CYDRYLARVE EMRQSLSIIY QCLNKMPRGS VKIDDAKISP 300
    PSRSEVKQSM ESLIHHFKLY TEGVFVPAGE TYTATEAPKG EFGVYLVSKG 350
    SSRPYRCKIK APGFSHLQGL NFMACSHMLA DVVTIIGTQD IVFGEVDR 398
    Length:398
    Mass (Da):45,245
    Last modified:November 1, 1996 - v1
    Checksum:iD3C46D2B7CA33FF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48623 Genomic DNA. Translation: CAA88557.1.
    PIRiS53054.
    RefSeqiNP_150429.1. NC_003055.1.

    Genome annotation databases

    GeneIDi803753.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48623 Genomic DNA. Translation: CAA88557.1 .
    PIRi S53054.
    RefSeqi NP_150429.1. NC_003055.1.

    3D structure databases

    ProteinModelPortali Q37720.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 803753.

    Family and domain databases

    Gene3Di 1.10.645.10. 2 hits.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation of the cox3, nad7 and atp6 genes from the mitochondrial genome of the brown alga Pylaiella littoralis."
      Fontaine J.-M., Rousvoal S., Delaroque N., Loiseaux-De Goer S.
      Plant Physiol. Biochem. 33:605-609(1995)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiNDUS2_PYLLI
    AccessioniPrimary (citable) accession number: Q37720
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: June 11, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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