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Q37705

- COX1_ARTSF

UniProt

Q37705 - COX1_ARTSF

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron (heme A axial ligand)Curated
    Metal bindingi238 – 2381Copper BCurated
    Metal bindingi242 – 2421Copper BCurated
    Metal bindingi288 – 2881Copper BCurated
    Metal bindingi289 – 2891Copper BCurated
    Metal bindingi374 – 3741Iron (heme A3 axial ligand)Curated
    Metal bindingi376 – 3761Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Synonyms:CO-I
    Encoded oniMitochondrion
    OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
    Taxonomic identifieri6661 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Cytochrome c oxidase subunit 1PRO_0000183287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ37705.
    SMRiQ37705. Positions 1-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q37705-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRWFYSTNH KDIGTLYFIF GAWAGMVGTS LSMLIRAELG QPGSLIGDEQ    50
    VYNVIVTAHA FIMIFFMVMP ILIGGFGNWL VPIMLGAPDM AFPRLNNLSF 100
    WMLPPSLTLL LASSMVESGA GTGWTVYPPL SSAIAHAGPS VDLAIFSLHL 150
    AGVSSILGAV NFITTIINMR PQSMSIDRMP LFVWAVGITA VLLLLSLPVL 200
    AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG 250
    MVSHIISQES GKKEAFGTLG MIYAMLAIGI LGFVVWAHHM FTVGMDVDTR 300
    AYFTAATMII AIPTGIKIFS WIGTLHGTRL TMTPSMLWAL GFVFLFTVGG 350
    LTGVVLSNSS IDIVLHDTYY VVAHFHYVLS MGAVFAIMAG FVHWFPLMTG 400
    LSMNQFLLKV HFFIMFLGVN LTFFPQHFLG LAGMPRRYAD YPDTYASWNV 450
    ISSLGSVMSM IATLMFIFCI WEAMIAKRIN IFSLNLSSSV EWNHPHPPAD 500
    HSYEEITMIS TF 512
    Length:512
    Mass (Da):56,492
    Last modified:November 1, 1996 - v1
    Checksum:i4AA1E1BBE64913E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69067 Genomic DNA. Translation: CAA48806.1.
    PIRiS60622.
    RefSeqiNP_007109.1. NC_001620.1.

    Genome annotation databases

    GeneIDi807790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69067 Genomic DNA. Translation: CAA48806.1 .
    PIRi S60622.
    RefSeqi NP_007109.1. NC_001620.1.

    3D structure databases

    ProteinModelPortali Q37705.
    SMRi Q37705. Positions 1-510.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 807790.

    Organism-specific databases

    CTDi 4512.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Speciation in the Artemia genus: mitochondrial DNA analysis of bisexual and parthenogenetic brine shrimps."
      Perez M.L., Valverde J.R., Batuecas B., Amat F., Marco R., Garesse R.
      J. Mol. Evol. 38:156-168(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_ARTSF
    AccessioniPrimary (citable) accession number: Q37705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3