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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme A axial ligand)Curated
Metal bindingi238 – 2381Copper BCurated
Metal bindingi242 – 2421Copper BCurated
Metal bindingi288 – 2881Copper BCurated
Metal bindingi289 – 2891Copper BCurated
Metal bindingi374 – 3741Iron (heme A3 axial ligand)Curated
Metal bindingi376 – 3761Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Synonyms:CO-I
Encoded oniMitochondrion
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence AnalysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome c oxidase subunit 1PRO_0000183287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ37705.
SMRiQ37705. Positions 1-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRWFYSTNH KDIGTLYFIF GAWAGMVGTS LSMLIRAELG QPGSLIGDEQ
60 70 80 90 100
VYNVIVTAHA FIMIFFMVMP ILIGGFGNWL VPIMLGAPDM AFPRLNNLSF
110 120 130 140 150
WMLPPSLTLL LASSMVESGA GTGWTVYPPL SSAIAHAGPS VDLAIFSLHL
160 170 180 190 200
AGVSSILGAV NFITTIINMR PQSMSIDRMP LFVWAVGITA VLLLLSLPVL
210 220 230 240 250
AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG
260 270 280 290 300
MVSHIISQES GKKEAFGTLG MIYAMLAIGI LGFVVWAHHM FTVGMDVDTR
310 320 330 340 350
AYFTAATMII AIPTGIKIFS WIGTLHGTRL TMTPSMLWAL GFVFLFTVGG
360 370 380 390 400
LTGVVLSNSS IDIVLHDTYY VVAHFHYVLS MGAVFAIMAG FVHWFPLMTG
410 420 430 440 450
LSMNQFLLKV HFFIMFLGVN LTFFPQHFLG LAGMPRRYAD YPDTYASWNV
460 470 480 490 500
ISSLGSVMSM IATLMFIFCI WEAMIAKRIN IFSLNLSSSV EWNHPHPPAD
510
HSYEEITMIS TF
Length:512
Mass (Da):56,492
Last modified:November 1, 1996 - v1
Checksum:i4AA1E1BBE64913E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69067 Genomic DNA. Translation: CAA48806.1.
PIRiS60622.
RefSeqiNP_007109.1. NC_001620.1.

Genome annotation databases

GeneIDi807790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69067 Genomic DNA. Translation: CAA48806.1.
PIRiS60622.
RefSeqiNP_007109.1. NC_001620.1.

3D structure databases

ProteinModelPortaliQ37705.
SMRiQ37705. Positions 1-510.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi807790.

Organism-specific databases

CTDi4512.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Speciation in the Artemia genus: mitochondrial DNA analysis of bisexual and parthenogenetic brine shrimps."
    Perez M.L., Valverde J.R., Batuecas B., Amat F., Marco R., Garesse R.
    J. Mol. Evol. 38:156-168(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_ARTSF
AccessioniPrimary (citable) accession number: Q37705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.