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Q37705

- COX1_ARTSF

UniProt

Q37705 - COX1_ARTSF

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Protein
Cytochrome c oxidase subunit 1
Gene
COI, CO-I
Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme A axial ligand) Inferred
Metal bindingi238 – 2381Copper B Inferred
Metal bindingi242 – 2421Copper B Inferred
Metal bindingi288 – 2881Copper B Inferred
Metal bindingi289 – 2891Copper B Inferred
Metal bindingi374 – 3741Iron (heme A3 axial ligand) Inferred
Metal bindingi376 – 3761Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Synonyms:CO-I
Encoded oniMitochondrion
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed prediction
Add
BLAST
Transmembranei54 – 7421Helical; Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Transmembranei181 – 20121Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Transmembranei412 – 43221Helical; Reviewed prediction
Add
BLAST
Transmembranei450 – 47021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome c oxidase subunit 1
PRO_0000183287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ37705.
SMRiQ37705. Positions 1-510.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37705-1 [UniParc]FASTAAdd to Basket

« Hide

MQRWFYSTNH KDIGTLYFIF GAWAGMVGTS LSMLIRAELG QPGSLIGDEQ    50
VYNVIVTAHA FIMIFFMVMP ILIGGFGNWL VPIMLGAPDM AFPRLNNLSF 100
WMLPPSLTLL LASSMVESGA GTGWTVYPPL SSAIAHAGPS VDLAIFSLHL 150
AGVSSILGAV NFITTIINMR PQSMSIDRMP LFVWAVGITA VLLLLSLPVL 200
AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG 250
MVSHIISQES GKKEAFGTLG MIYAMLAIGI LGFVVWAHHM FTVGMDVDTR 300
AYFTAATMII AIPTGIKIFS WIGTLHGTRL TMTPSMLWAL GFVFLFTVGG 350
LTGVVLSNSS IDIVLHDTYY VVAHFHYVLS MGAVFAIMAG FVHWFPLMTG 400
LSMNQFLLKV HFFIMFLGVN LTFFPQHFLG LAGMPRRYAD YPDTYASWNV 450
ISSLGSVMSM IATLMFIFCI WEAMIAKRIN IFSLNLSSSV EWNHPHPPAD 500
HSYEEITMIS TF 512
Length:512
Mass (Da):56,492
Last modified:November 1, 1996 - v1
Checksum:i4AA1E1BBE64913E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69067 Genomic DNA. Translation: CAA48806.1.
PIRiS60622.
RefSeqiNP_007109.1. NC_001620.1.

Genome annotation databases

GeneIDi807790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69067 Genomic DNA. Translation: CAA48806.1 .
PIRi S60622.
RefSeqi NP_007109.1. NC_001620.1.

3D structure databases

ProteinModelPortali Q37705.
SMRi Q37705. Positions 1-510.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807790.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Speciation in the Artemia genus: mitochondrial DNA analysis of bisexual and parthenogenetic brine shrimps."
    Perez M.L., Valverde J.R., Batuecas B., Amat F., Marco R., Garesse R.
    J. Mol. Evol. 38:156-168(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_ARTSF
AccessioniPrimary (citable) accession number: Q37705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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