Q37679 (COX3_THEAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	MT-CO3
Synonyms:	COIII, COXIII, MTCO3
ORF Names:	Tap370b08.q2ca38.02c

Encoded on

Mitochondrion

Organism

Theileria annulata [Reference proteome]

Taxonomic identifier

5874 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Piroplasmida › Theileriidae › Theileria

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Cytochrome c oxidase subunit 3		PRO_0000183862
Regions
	Transmembrane	12 – 29	18	Helical; Potential
	Transmembrane	57 – 77	21	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	235 – 255	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q37679 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1C42F4BC0A6F1336	FASTA	255	29,717
	10 20 30 40 50 60 MRNSVQSDLK YINIINISET LYLFYSTGLD TLEYIDSTYK NFIIMYVNQH LLYGTTLKYL 70 80 90 100 110 120 SVGEFFINSL TIFINGIRET MTSSTVIMYA IFGMFIFSEI MVFSTFIWGF FHFRLSNPVM 130 140 150 160 170 180 IIEVNLEAFL QISDVLNAGS ILISLILQRI EERGYFEVDY MLERLILIGF IFLSFQGDEY 190 200 210 220 230 240 SLVKSYINNH WVTLYFNVLT GLHSLHVYVG GIFALMQAFA SENCGCQKDE DFNAGMYWHF 250 VEIIWIALTM LLFLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Synonymous codon usage (SCU) bias differentiates Theilerial nuclear genes from mitochondrial ones." Lawson D., Hall R. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Hissar.
[2]	"Genome of the host-cell transforming parasite Theileria annulata compared with T. parva." Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W., Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R., Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A. , Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P., McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C., Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D., Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R., Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D., Shiels B., Tait A., Barrell B.G., Hall N. Science 309:131-133(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ankara.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32225 Genomic DNA. Translation: AAA73631.1. CR940346 Genomic DNA. Translation: CAI72675.1.
RefSeq	XP_954717.1. XM_949624.1.
3D structure databases
ProteinModelPortal	Q37679.
ModBase	Search...
Protein-protein interaction databases
STRING	5874.Q37679.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3864553.
Phylogenomic databases
eggNOG	COG1845.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_THEAN

Accession

Primary (citable) accession number: Q37679
Secondary accession number(s): Q4UJ68

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)