Q37677 (COX2_SALSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	mt-co2
Synonyms:	coii, coxii, mtco2

Encoded on

Mitochondrion

Organism

Salmo salar (Atlantic salmon)

Taxonomic identifier

8030 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonoidei › Salmonidae › Salmoninae › Salmo

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Cytochrome c oxidase subunit 2		PRO_0000183683
Regions
	Topological domain	1 – 26	26	Mitochondrial intermembrane Potential
	Transmembrane	27 – 48	22	Helical; Probable
	Topological domain	49 – 62	14	Mitochondrial matrix Potential
	Transmembrane	63 – 82	20	Helical; Probable
	Topological domain	83 – 230	148	Mitochondrial intermembrane Potential
Sites
	Metal binding	161	1	Copper A Probable
	Metal binding	196	1	Copper A Probable
	Metal binding	200	1	Copper A Probable
	Metal binding	204	1	Copper A Probable
Experimental info
	Sequence conflict	175	1	S → V in AAD04736. Ref.1
	Sequence conflict	209	1	I → V in AAB08524. Ref.3
	Sequence conflict	227 – 230	4	LEDA → TW in AAB08524. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q37677 [UniParc]. Last modified January 11, 2001. Version 3. Checksum: 405C95AA58112AF4	FASTA	230	26,016
	10 20 30 40 50 60 MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VLLISTLVLY IIVAMVSTKL TNKYILDSQE 70 80 90 100 110 120 IEIVWTVLPA VILILIALPS LRILYLMDEI NDPHLTIKAM GHQWYWSYEY TDYEDLGFDS 130 140 150 160 170 180 YMVPTQDLTP GQFRLLETDH RMVVPVESPI RVLVSAEDVL HSWAVPSLGV KMDASPGRLN 190 200 210 220 230 QTAFIASRPG VFYGQCSEIC GANHSFMPIV VEAVPLEHFE KWSTMMLEDA

References

[1]	"The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo salar." Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J. Gene 239:237-242(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"The complete mitochondrial genome sequence of a teleost, Salmo salar, and comparisons with other salmoniformes." Arnason U., Johnsson E., Rasmussen A.S. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Isolation of Atlantic Salmon (Salmo salar) cytochrome c oxidase subunit II gene (coxII)." Hardiman G.T., Wolff J., Peden J., Gannon F. J. Appl. Ichthyol. 10:64-68(1994) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-230. Tissue: Kidney.
[4]	Hardiman G.T. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12143 Genomic DNA. Translation: AAD04736.1. AF133701 Genomic DNA. Translation: AAF61381.1. L04501 Genomic DNA. Translation: AAB08524.1.
PIR	T09950.
RefSeq	NP_008448.1. NC_001960.1.
3D structure databases
ProteinModelPortal	Q37677.
SMR	Q37677. Positions 1-227.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	808315.
Organism-specific databases
CTD	4513.
Phylogenomic databases
HOVERGEN	HBG012727.
ProtClustDB	MTH00129.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_SALSA

Accession

Primary (citable) accession number: Q37677
Secondary accession number(s): Q9MPG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 11, 2001
Last modified:	May 1, 2013
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program