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Q37677

- COX2_SALSA

UniProt

Q37677 - COX2_SALSA

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Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ACurated
Metal bindingi196 – 1961Copper ACurated
Metal bindingi200 – 2001Copper ACurated
Metal bindingi204 – 2041Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded oniMitochondrion
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4822HelicalCuratedAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalCuratedAdd
BLAST
Topological domaini83 – 230148Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Cytochrome c oxidase subunit 2PRO_0000183683Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ37677.
SMRiQ37677. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37677-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VLLISTLVLY IIVAMVSTKL
60 70 80 90 100
TNKYILDSQE IEIVWTVLPA VILILIALPS LRILYLMDEI NDPHLTIKAM
110 120 130 140 150
GHQWYWSYEY TDYEDLGFDS YMVPTQDLTP GQFRLLETDH RMVVPVESPI
160 170 180 190 200
RVLVSAEDVL HSWAVPSLGV KMDASPGRLN QTAFIASRPG VFYGQCSEIC
210 220 230
GANHSFMPIV VEAVPLEHFE KWSTMMLEDA
Length:230
Mass (Da):26,016
Last modified:January 11, 2001 - v3
Checksum:i405C95AA58112AF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751S → V in AAD04736. (PubMed:10548724)Curated
Sequence conflicti209 – 2091I → V in AAB08524. 1 PublicationCurated
Sequence conflicti227 – 2304LEDA → TW in AAB08524. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12143 Genomic DNA. Translation: AAD04736.1.
AF133701 Genomic DNA. Translation: AAF61381.1.
L04501 Genomic DNA. Translation: AAB08524.1.
PIRiT09950.
RefSeqiNP_008448.1. NC_001960.1.

Genome annotation databases

GeneIDi808315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12143 Genomic DNA. Translation: AAD04736.1 .
AF133701 Genomic DNA. Translation: AAF61381.1 .
L04501 Genomic DNA. Translation: AAB08524.1 .
PIRi T09950.
RefSeqi NP_008448.1. NC_001960.1.

3D structure databases

ProteinModelPortali Q37677.
SMRi Q37677. Positions 1-227.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808315.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

HOVERGENi HBG012727.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo salar."
    Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.
    Gene 239:237-242(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "The complete mitochondrial genome sequence of a teleost, Salmo salar, and comparisons with other salmoniformes."
    Arnason U., Johnsson E., Rasmussen A.S.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Isolation of Atlantic Salmon (Salmo salar) cytochrome c oxidase subunit II gene (coxII)."
    Hardiman G.T., Wolff J., Peden J., Gannon F.
    J. Appl. Ichthyol. 10:64-68(1994)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-230.
    Tissue: Kidney.
  4. Hardiman G.T.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiCOX2_SALSA
AccessioniPrimary (citable) accession number: Q37677
Secondary accession number(s): Q9MPG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: November 26, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3