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Protein

Cytochrome c oxidase subunit 2

Gene

mt-co2

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded oniMitochondrion
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26Mitochondrial intermembraneSequence analysisAdd BLAST26
Transmembranei27 – 48HelicalCuratedAdd BLAST22
Topological domaini49 – 62Mitochondrial matrixSequence analysisAdd BLAST14
Transmembranei63 – 82HelicalCuratedAdd BLAST20
Topological domaini83 – 230Mitochondrial intermembraneSequence analysisAdd BLAST148

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836831 – 230Cytochrome c oxidase subunit 2Add BLAST230

Structurei

3D structure databases

ProteinModelPortaliQ37677
SMRiQ37677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727
KOiK02261

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q37677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VLLISTLVLY IIVAMVSTKL
60 70 80 90 100
TNKYILDSQE IEIVWTVLPA VILILIALPS LRILYLMDEI NDPHLTIKAM
110 120 130 140 150
GHQWYWSYEY TDYEDLGFDS YMVPTQDLTP GQFRLLETDH RMVVPVESPI
160 170 180 190 200
RVLVSAEDVL HSWAVPSLGV KMDASPGRLN QTAFIASRPG VFYGQCSEIC
210 220 230
GANHSFMPIV VEAVPLEHFE KWSTMMLEDA
Length:230
Mass (Da):26,016
Last modified:January 11, 2001 - v3
Checksum:i405C95AA58112AF4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175S → V in AAD04736 (PubMed:10548724).Curated1
Sequence conflicti209I → V in AAB08524 (Ref. 3) Curated1
Sequence conflicti227 – 230LEDA → TW in AAB08524 (Ref. 3) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12143 Genomic DNA Translation: AAD04736.1
AF133701 Genomic DNA Translation: AAF61381.1
L04501 Genomic DNA Translation: AAB08524.1
PIRiT09950
RefSeqiNP_008448.1, NC_001960.1

Genome annotation databases

GeneIDi808315
KEGGisasa:808315

Similar proteinsi

Entry informationi

Entry nameiCOX2_SALSA
AccessioniPrimary (citable) accession number: Q37677
Secondary accession number(s): Q9MPG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health