Q37620 (COX3_PROWI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COX3

Encoded on

Mitochondrion

Organism

Prototheca wickerhamii

Taxonomic identifier

3111 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Chlorophyta › Trebouxiophyceae › Chlorellales › Chlorellaceae › Prototheca

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Cytochrome c oxidase subunit 3		PRO_0000183839
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	159 – 179	21	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q37620 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F4CC81AB17C2850E	FASTA	262	29,600
	10 20 30 40 50 60 MRKHPFHLVD PSPWPLLASF AAFLSTTGGV MYMHAYSGGG LLLAIGQLSL FYVMYVWWRD 70 80 90 100 110 120 VIREGTYQGH HTNPVQVGLR YGMLLFILSE IMFFFAFFWA FFHSSLAPTI EIGAVWPPKG 130 140 150 160 170 180 IQVLNPWEIP FLNTIILLTS GASVTWAHHA ILAGNRKQGI ISLAITVLLA VIFTGFQALE 190 200 210 220 230 240 YLEAPFTISD GIYGSTFYLA TGFHGFHVII GTIFIAVCLF RLVLHHFSKS HHLGFEAAAW 250 260 YWHMVDVVWL FLFVCIYYWG GA

References

[1]

"Complete sequence of the mitochondrial DNA of the chlorophyte alga Prototheca wickerhamii. Gene content and genome organization." Wolff G., Plante I., Lang B.F., Kueck U., Burger G. J. Mol. Biol. 237:75-86(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 263-11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02970 Genomic DNA. Translation: AAD12641.1.
PIR	T11922.
RefSeq	NP_042253.1. NC_001613.1.
3D structure databases
ProteinModelPortal	Q37620.
SMR	Q37620. Positions 2-260.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	802127.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_PROWI

Accession

Primary (citable) accession number: Q37620

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program