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Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

NAD7

Organism
Prototheca wickerhamii
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiPrototheca wickerhamii
Taxonomic identifieri3111 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaTrebouxiophyceaeChlorellalesChlorellaceaePrototheca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185911 – 400NADH-ubiquinone oxidoreductase 49 kDa subunitAdd BLAST400

Structurei

3D structure databases

ProteinModelPortaliQ37619
SMRiQ37619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

Q37619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALEKIITAP KYKNFTINFG PQHPAAHGVL RLVLEMNGEV VQRSDPHIGL
60 70 80 90 100
LHRGTEKLIE YKNYLQALPY FDRLDYVSMM CQEHAYSLAV EKLLNISKDI
110 120 130 140 150
PLRAQYIRVL FSEITRILNH LLAVTCHAMD VGALTPFLWG FEEREKLMEF
160 170 180 190 200
YERVSGARMH AAYIRPGGVA LDLPLGLCED IYKFSKQFAS RIDEIEEMLT
210 220 230 240 250
SNRIWKQRLV DVGVVSAEQA LDWSFSGVLL RGSGIAWDLR KTQPYEVYDR
260 270 280 290 300
MKFNIPVGTR GDCYDRYLIR VQEMRESLRI VMQTINEMSK GIIRLDDRKI
310 320 330 340 350
TPPTRDQMKQ SMESLIHHFK FYTGGFVVPA GETYTAVEAP KGEFGVYLVS
360 370 380 390 400
NGTSKPYRCK IRAPGFAHLQ GLDFMARNHM LADVVTIIGT QDIVFGEVDR
Length:400
Mass (Da):45,810
Last modified:November 1, 1996 - v1
Checksum:i7227458FE80BC9D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02970 Genomic DNA Translation: AAD12640.1
PIRiT11921
RefSeqiNP_042252.1, NC_001613.1

Genome annotation databases

GeneIDi802126

Similar proteinsi

Entry informationi

Entry nameiNDUS2_PROWI
AccessioniPrimary (citable) accession number: Q37619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health