Q37619 (NDUS2_PROWI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit
EC=1.6.5.3
EC=1.6.99.3

Alternative name(s):
NADH dehydrogenase subunit 7

Gene names

Name:

NAD7

Encoded on

Mitochondrion

Organism

Prototheca wickerhamii

Taxonomic identifier

3111 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Chlorophyta › Trebouxiophyceae › Chlorellales › Chlorellaceae › Prototheca

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	NADH-ubiquinone oxidoreductase 49 kDa subunit		PRO_0000118591

Sequences

	Sequence		Length	Mass (Da)
	Q37619 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7227458FE80BC9D2	FASTA	400	45,810
	10 20 30 40 50 60 MALEKIITAP KYKNFTINFG PQHPAAHGVL RLVLEMNGEV VQRSDPHIGL LHRGTEKLIE 70 80 90 100 110 120 YKNYLQALPY FDRLDYVSMM CQEHAYSLAV EKLLNISKDI PLRAQYIRVL FSEITRILNH 130 140 150 160 170 180 LLAVTCHAMD VGALTPFLWG FEEREKLMEF YERVSGARMH AAYIRPGGVA LDLPLGLCED 190 200 210 220 230 240 IYKFSKQFAS RIDEIEEMLT SNRIWKQRLV DVGVVSAEQA LDWSFSGVLL RGSGIAWDLR 250 260 270 280 290 300 KTQPYEVYDR MKFNIPVGTR GDCYDRYLIR VQEMRESLRI VMQTINEMSK GIIRLDDRKI 310 320 330 340 350 360 TPPTRDQMKQ SMESLIHHFK FYTGGFVVPA GETYTAVEAP KGEFGVYLVS NGTSKPYRCK 370 380 390 400 IRAPGFAHLQ GLDFMARNHM LADVVTIIGT QDIVFGEVDR

References

[1]

"Complete sequence of the mitochondrial DNA of the chlorophyte alga Prototheca wickerhamii. Gene content and genome organization." Wolff G., Plante I., Lang B.F., Kueck U., Burger G. J. Mol. Biol. 237:75-86(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 263-11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02970 Genomic DNA. Translation: AAD12640.1.
PIR	T11921.
RefSeq	NP_042252.1. NC_001613.1.
3D structure databases
ProteinModelPortal	Q37619.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	802126.
Family and domain databases
InterPro	IPR001135. NADH_Q_OxRdtase_suD. IPR014029. NADH_UbQ_OxRdtase_49kDa_CS. IPR022885. NDH1_su_D/H. [Graphical view]
Pfam	PF00346. Complex1_49kDa. 1 hit. [Graphical view]
TIGRFAMs	TIGR01962. NuoD. 1 hit.
PROSITE	PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS2_PROWI

Accession

Primary (citable) accession number: Q37619

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program