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Q37619 (NDUS2_PROWI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH dehydrogenase subunit 7
Gene names
Name:NAD7
Encoded onMitochondrion
OrganismPrototheca wickerhamii
Taxonomic identifier3111 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeChlorophytaTrebouxiophyceaeChlorellalesChlorellaceaePrototheca

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme. HAMAP-Rule MF_01358

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01358

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01358

Subcellular location

Mitochondrion HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMitochondrion
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400NADH-ubiquinone oxidoreductase 49 kDa subunit HAMAP-Rule MF_01358
PRO_0000118591

Sequences

Sequence LengthMass (Da)Tools
Q37619 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7227458FE80BC9D2

FASTA40045,810
        10         20         30         40         50         60 
MALEKIITAP KYKNFTINFG PQHPAAHGVL RLVLEMNGEV VQRSDPHIGL LHRGTEKLIE 

        70         80         90        100        110        120 
YKNYLQALPY FDRLDYVSMM CQEHAYSLAV EKLLNISKDI PLRAQYIRVL FSEITRILNH 

       130        140        150        160        170        180 
LLAVTCHAMD VGALTPFLWG FEEREKLMEF YERVSGARMH AAYIRPGGVA LDLPLGLCED 

       190        200        210        220        230        240 
IYKFSKQFAS RIDEIEEMLT SNRIWKQRLV DVGVVSAEQA LDWSFSGVLL RGSGIAWDLR 

       250        260        270        280        290        300 
KTQPYEVYDR MKFNIPVGTR GDCYDRYLIR VQEMRESLRI VMQTINEMSK GIIRLDDRKI 

       310        320        330        340        350        360 
TPPTRDQMKQ SMESLIHHFK FYTGGFVVPA GETYTAVEAP KGEFGVYLVS NGTSKPYRCK 

       370        380        390        400 
IRAPGFAHLQ GLDFMARNHM LADVVTIIGT QDIVFGEVDR 

« Hide

References

[1]"Complete sequence of the mitochondrial DNA of the chlorophyte alga Prototheca wickerhamii. Gene content and genome organization."
Wolff G., Plante I., Lang B.F., Kueck U., Burger G.
J. Mol. Biol. 237:75-86(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 263-11.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U02970 Genomic DNA. Translation: AAD12640.1.
PIRT11921.
RefSeqNP_042252.1. NC_001613.1.

3D structure databases

ProteinModelPortalQ37619.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID802126.

Family and domain databases

HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_PROWI
AccessionPrimary (citable) accession number: Q37619
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families