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Q37619

- NDUS2_PROWI

UniProt

Q37619 - NDUS2_PROWI

Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

NAD7

Organism
Prototheca wickerhamii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    3. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:NAD7
    Encoded oniMitochondrion
    OrganismiPrototheca wickerhamii
    Taxonomic identifieri3111 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeChlorophytaTrebouxiophyceaeChlorellalesChlorellaceaePrototheca

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400NADH-ubiquinone oxidoreductase 49 kDa subunitPRO_0000118591Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ37619.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Curated

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q37619-1 [UniParc]FASTAAdd to Basket

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    MALEKIITAP KYKNFTINFG PQHPAAHGVL RLVLEMNGEV VQRSDPHIGL    50
    LHRGTEKLIE YKNYLQALPY FDRLDYVSMM CQEHAYSLAV EKLLNISKDI 100
    PLRAQYIRVL FSEITRILNH LLAVTCHAMD VGALTPFLWG FEEREKLMEF 150
    YERVSGARMH AAYIRPGGVA LDLPLGLCED IYKFSKQFAS RIDEIEEMLT 200
    SNRIWKQRLV DVGVVSAEQA LDWSFSGVLL RGSGIAWDLR KTQPYEVYDR 250
    MKFNIPVGTR GDCYDRYLIR VQEMRESLRI VMQTINEMSK GIIRLDDRKI 300
    TPPTRDQMKQ SMESLIHHFK FYTGGFVVPA GETYTAVEAP KGEFGVYLVS 350
    NGTSKPYRCK IRAPGFAHLQ GLDFMARNHM LADVVTIIGT QDIVFGEVDR 400
    Length:400
    Mass (Da):45,810
    Last modified:November 1, 1996 - v1
    Checksum:i7227458FE80BC9D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02970 Genomic DNA. Translation: AAD12640.1.
    PIRiT11921.
    RefSeqiNP_042252.1. NC_001613.1.

    Genome annotation databases

    GeneIDi802126.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02970 Genomic DNA. Translation: AAD12640.1 .
    PIRi T11921.
    RefSeqi NP_042252.1. NC_001613.1.

    3D structure databases

    ProteinModelPortali Q37619.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 802126.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of the mitochondrial DNA of the chlorophyte alga Prototheca wickerhamii. Gene content and genome organization."
      Wolff G., Plante I., Lang B.F., Kueck U., Burger G.
      J. Mol. Biol. 237:75-86(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 263-11.

    Entry informationi

    Entry nameiNDUS2_PROWI
    AccessioniPrimary (citable) accession number: Q37619
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3