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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Polytomella sp. Pringsheim 198.80
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotationSAAS annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiPolytomella sp. Pringsheim 198.80Imported
Taxonomic identifieri37502 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaePolytomella

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 36HelicalSequence analysisAdd BLAST25
Transmembranei56 – 82HelicalSequence analysisAdd BLAST27
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei180 – 208HelicalSequence analysisAdd BLAST29
Transmembranei228 – 249HelicalSequence analysisAdd BLAST22
Transmembranei261 – 283HelicalSequence analysisAdd BLAST23
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei327 – 353HelicalSequence analysisAdd BLAST27
Transmembranei365 – 389HelicalSequence analysisAdd BLAST25
Transmembranei409 – 430HelicalSequence analysisAdd BLAST22
Transmembranei450 – 473HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ37612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 501COX1InterPro annotationAdd BLAST501

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLYSTNHK DIGMLYLIFA FFGGLVGTGL SVLIRLQLAT TGTGILQNNG
60 70 80 90 100
QLFNVIVTGH GVIMLLFMVM PALFGGFGNY LLPLMIGAPD MAFPRLNNIS
110 120 130 140 150
FWLNPFGFLL LLVSTLVEQG AGTGWTLYPP LSVQGSGSSI DLAILSFDLN
160 170 180 190 200
GLSSILGSIN VLVTAKGLRA PGMSLIQIPL FVYSMVFTAI LVILSVPVLA
210 220 230 240 250
AALIMLLTDR SLNTAYFVDS GDLLLYQHLF WFFGHPEVYI LILPAFGLIS
260 270 280 290 300
SIISFFSNKP VFGVTGMICA MGAIGLVGFL VWAHHMYVVG MDLDTVAYFT
310 320 330 340 350
SASMIIAIPT GMKVFSWMAT AYAGKVYFSV PMLYAFGFLA LFTIGGVTGV
360 370 380 390 400
VLANAGVDTA VHDTYYVVAH FHYVLSTGAV FAIFAGMYFY SNLMFNLGYD
410 420 430 440 450
ENKGTVQFLL FFLGVNLTFF PQHFLGLAGM PRRMFDYRDA FTGLNLLSSY
460 470 480 490 500
GALVSFTSLL YAGTVFTPAP ALYQNRTSTS LEWLLPATPA FHTFSEVPVL

RVA
Length:503
Mass (Da):54,782
Last modified:November 1, 1996 - v1
Checksum:i61E3F2AE5AABBCA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31972 Genomic DNA. Translation: AAC24895.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31972 Genomic DNA. Translation: AAC24895.1.

3D structure databases

ProteinModelPortaliQ37612.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ37612_9CHLO
AccessioniPrimary (citable) accession number: Q37612
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.