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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotationSAAS annotation
Gene namesi
Name:COIIImported
Synonyms:CO2Imported, COX2Imported
Encoded oniMitochondrionImported
OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)Imported
Taxonomic identifieri9597 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 46HelicalSequence analysisAdd BLAST20
Transmembranei66 – 85HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ37608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91COX2_TMInterPro annotationAdd BLAST91
Domaini92 – 225COX2_CUAInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012727

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q37608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAAQVGLQ DATSPIMEEL IIFHDHALMI IFLICFLVLY ALFLTLTTKL
60 70 80 90 100
TNTSISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSFTIKSI
110 120 130 140 150
GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPVEAPV
160 170 180 190 200
RMMITSQDVL HSWAIPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC
210 220
GANHSFMPIV LELIPLKIFE MGPVFTL
Length:227
Mass (Da):25,570
Last modified:November 1, 1996 - v1
Checksum:iB387D718473C64A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12695 Genomic DNA Translation: AAA20848.1
GU189673 Genomic DNA Translation: ADA55708.1
GU189674 Genomic DNA Translation: ADA55721.1
JN191196 Genomic DNA Translation: AEO20527.1
KU353708 Genomic DNA Translation: AMB65315.1
KU353709 Genomic DNA Translation: AMB65328.1
KU353710 Genomic DNA Translation: AMB65341.1
KX211936 Genomic DNA Translation: ANP95576.1

Entry informationi

Entry nameiQ37608_PANPA
AccessioniPrimary (citable) accession number: Q37608
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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