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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotationSAAS annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation
Gene namesi
Name:COIIImported
Synonyms:CO2Imported, COX2Imported
Encoded oniMitochondrionImported
OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)Imported
Taxonomic identifieri9597 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

  • Mitochondrion inner membrane SAAS annotation
  • Mitochondrion inner membrane UniRule annotationSAAS annotation; Multi-pass membrane protein UniRule annotationSAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4620HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiQ37608. Positions 1-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191COX2_TMInterPro annotationAdd
BLAST
Domaini92 – 225134COX2_CUAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAAQVGLQ DATSPIMEEL IIFHDHALMI IFLICFLVLY ALFLTLTTKL
60 70 80 90 100
TNTSISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSFTIKSI
110 120 130 140 150
GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPVEAPV
160 170 180 190 200
RMMITSQDVL HSWAIPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC
210 220
GANHSFMPIV LELIPLKIFE MGPVFTL
Length:227
Mass (Da):25,570
Last modified:November 1, 1996 - v1
Checksum:iB387D718473C64A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12695 Genomic DNA. Translation: AAA20848.1.
GU189673 Genomic DNA. Translation: ADA55708.1.
GU189674 Genomic DNA. Translation: ADA55721.1.
JN191196 Genomic DNA. Translation: AEO20527.1.
KU353708 Genomic DNA. Translation: AMB65315.1.
KU353709 Genomic DNA. Translation: AMB65328.1.
KU353710 Genomic DNA. Translation: AMB65341.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12695 Genomic DNA. Translation: AAA20848.1.
GU189673 Genomic DNA. Translation: ADA55708.1.
GU189674 Genomic DNA. Translation: ADA55721.1.
JN191196 Genomic DNA. Translation: AEO20527.1.
KU353708 Genomic DNA. Translation: AMB65315.1.
KU353709 Genomic DNA. Translation: AMB65328.1.
KU353710 Genomic DNA. Translation: AMB65341.1.

3D structure databases

SMRiQ37608. Positions 1-220.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mitochondrial COII sequences and modern human origins."
    Ruvolo M., Zehr S., von Dornum M., Pan D., Chang B., Lin J.
    Mol. Biol. Evol. 10:1115-1135(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Ruvolo M.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Distinct patterns of mitochondrial genome diversity in bonobos (Pan paniscus) and humans."
    Zsurka G., Kudina T., Peeva V., Hallmann K., Elger C.E., Khrapko K., Kunz W.S.
    BMC Evol. Biol. 10:270-270(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PP57Imported and PP75Imported.
  4. "Contrasting demographic histories of the neighboring bonobo and chimpanzee."
    Hvilsom C., Carlsen F., Heller R., Jaffre N., Siegismund H.R.
    Primates 55:101-112(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 167MubikisiImported.
  5. "Great-ape Y-chromosome and mitochondrial DNA phylogenies reflect sub-species structure and patterns of mating and dispersal."
    Hallast P., Maisano Delser P., Jobling M.A.
    Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PPA-MasikiniImported, PPA_BonoImported and PPA_PPA2Imported.

Entry informationi

Entry nameiQ37608_PANPA
AccessioniPrimary (citable) accession number: Q37608
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.