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Q37604

- COX2_PETMA

UniProt

Q37604 - COX2_PETMA

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Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Petromyzon marinus (Sea lamprey)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper ABy similarity
Metal bindingi196 – 1961Copper ABy similarity
Metal bindingi200 – 2001Copper ABy similarity
Metal bindingi204 – 2041Copper ABy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiPetromyzon marinus (Sea lamprey)
Taxonomic identifieri7757 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Cytochrome c oxidase subunit 2PRO_0000183658Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ37604.
SMRiQ37604. Positions 1-227.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini49 – 6214Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini83 – 229147Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4822HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8220HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017410.
HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37604-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQQAQLGLQ DAASPIMEEL IHFHDHTLTV VFLISVLIFY LIIVMVTTTF
60 70 80 90 100
MNKHSLDSQE VEIVWTVMPA IVLITIALPS LRILYLTDEI SNPHLTIKAV
110 120 130 140 150
GHQWYWSYEY TDYHQMEFDS YMIPTNELEP GGIRLLDVDH RIVVPMESPV
160 170 180 190 200
RMLITSEDVI HSWTIPSLGT KVDAVPGRLN QATFITTRPG LFFGQCSEIC
210 220
GANHSFMPIA LEAVPLSNFE NWTTKVLAS
Length:229
Mass (Da):25,916
Last modified:November 1, 1996 - v1
Checksum:i58D5A727E56C293E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11880 Genomic DNA. Translation: AAB08741.1.
PIRiS55007.
RefSeqiNP_008151.1. NC_001626.1.

Genome annotation databases

EnsembliENSPMAT00000014125; ENSPMAP00000011434; ENSPMAG00000013098.
GeneIDi807803.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11880 Genomic DNA. Translation: AAB08741.1 .
PIRi S55007.
RefSeqi NP_008151.1. NC_001626.1.

3D structure databases

ProteinModelPortali Q37604.
SMRi Q37604. Positions 1-227.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPMAT00000014125 ; ENSPMAP00000011434 ; ENSPMAG00000013098 .
GeneIDi 807803.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

GeneTreei ENSGT00390000017410.
HOVERGENi HBG012727.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of a sea lamprey (Petromyzon marinus) mitochondrial genome: early establishment of the vertebrate genome organization."
    Lee W.J., Kocher T.D.
    Genetics 139:873-887(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_PETMA
AccessioniPrimary (citable) accession number: Q37604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3