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Q37604

- COX2_PETMA

UniProt

Q37604 - COX2_PETMA

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Protein
Cytochrome c oxidase subunit 2
Gene
MT-CO2, COII, COXII, MTCO2
Organism
Petromyzon marinus (Sea lamprey)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper A By similarity
Metal bindingi196 – 1961Copper A By similarity
Metal bindingi200 – 2001Copper A By similarity
Metal bindingi204 – 2041Copper A By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiPetromyzon marinus (Sea lamprey)
Taxonomic identifieri7757 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei27 – 4822Helical; Reviewed prediction
Add
BLAST
Topological domaini49 – 6214Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei63 – 8220Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 229147Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Cytochrome c oxidase subunit 2
PRO_0000183658Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ37604.
SMRiQ37604. Positions 1-227.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017410.
HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37604-1 [UniParc]FASTAAdd to Basket

« Hide

MAQQAQLGLQ DAASPIMEEL IHFHDHTLTV VFLISVLIFY LIIVMVTTTF    50
MNKHSLDSQE VEIVWTVMPA IVLITIALPS LRILYLTDEI SNPHLTIKAV 100
GHQWYWSYEY TDYHQMEFDS YMIPTNELEP GGIRLLDVDH RIVVPMESPV 150
RMLITSEDVI HSWTIPSLGT KVDAVPGRLN QATFITTRPG LFFGQCSEIC 200
GANHSFMPIA LEAVPLSNFE NWTTKVLAS 229
Length:229
Mass (Da):25,916
Last modified:November 1, 1996 - v1
Checksum:i58D5A727E56C293E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11880 Genomic DNA. Translation: AAB08741.1.
PIRiS55007.
RefSeqiNP_008151.1. NC_001626.1.

Genome annotation databases

EnsembliENSPMAT00000014125; ENSPMAP00000011434; ENSPMAG00000013098.
GeneIDi807803.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11880 Genomic DNA. Translation: AAB08741.1 .
PIRi S55007.
RefSeqi NP_008151.1. NC_001626.1.

3D structure databases

ProteinModelPortali Q37604.
SMRi Q37604. Positions 1-227.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPMAT00000014125 ; ENSPMAP00000011434 ; ENSPMAG00000013098 .
GeneIDi 807803.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

GeneTreei ENSGT00390000017410.
HOVERGENi HBG012727.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of a sea lamprey (Petromyzon marinus) mitochondrial genome: early establishment of the vertebrate genome organization."
    Lee W.J., Kocher T.D.
    Genetics 139:873-887(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_PETMA
AccessioniPrimary (citable) accession number: Q37604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi