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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Pylaiella littoralis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Encoded oniMitochondrion
OrganismiPylaiella littoralis
Taxonomic identifieri2885 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesPX cladePhaeophyceaeEctocarpalesAcinetosporaceaePylaiella

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Cytochrome c oxidase subunit 3PRO_0000183840Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ37600.
SMRiQ37600. Positions 7-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTAKMIQR HPFHLVDPSP WPLVAALGGL SLTFGGVLFM HNYEGGGELL
60 70 80 90 100
CLGFFTILYV MFTWWRDVIR EALFEGQHTL AVQQGLRMGM ILFIVSEIMF
110 120 130 140 150
FFAFFWAFFT SSISPVFNIG GVWPPTDVVA ISPWGLPFLN TILLLSSGAS
160 170 180 190 200
VTWAHHAIVG GLKKEAMQGL SVTLAFAIAF TAMQGFEYSG APFGMSDGVY
210 220 230 240 250
GSVFYMATGF HGFHVIIGTI FLFICTIRLY LSHFSCQHHF GFEAAAWYWH
260 270
FVDVVWLFLF LTIYWWGFNI TV
Length:272
Mass (Da):30,628
Last modified:November 1, 1996 - v1
Checksum:iB9EFF7803A08E8DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37967 Genomic DNA. Translation: CAA86022.1.
PIRiS57460.
RefSeqiNP_150402.1. NC_003055.1.

Genome annotation databases

GeneIDi803717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37967 Genomic DNA. Translation: CAA86022.1.
PIRiS57460.
RefSeqiNP_150402.1. NC_003055.1.

3D structure databases

ProteinModelPortaliQ37600.
SMRiQ37600. Positions 7-267.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi803717.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterisation of the cox3, nad7 and atp6 genes from the mitochondrial genome of the brown alga Pylaiella littoralis."
    Fontaine J.-M., Rousvoal S., Delaroque N., Loiseaux-De Goer S.
    Plant Physiol. Biochem. 33:605-609(1995)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_PYLLI
AccessioniPrimary (citable) accession number: Q37600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.