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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Odocoileus virginianus (White-tailed deer)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

CopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation
Gene namesi
Name:COX2Imported
Encoded oniMitochondrionImported
OrganismiOdocoileus virginianus (White-tailed deer)Imported
Taxonomic identifieri9874 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraCervidaeOdocoileinaeOdocoileus

Subcellular locationi

  • Mitochondrion inner membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4620HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191COX2_TMInterPro annotationAdd
BLAST
Domaini92 – 225134COX2_CUAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYPMQLGFQ DATSPIMEEL LHFHDHTLMI VFLISSLVLY IISLMLTTKL
60 70 80 90 100
THTSTMDAQE VETVWTILPA IILILIALPS LRILYMMDEI NNPSLTVKTM
110 120 130 140 150
GHQWYWSYEY TDYEDLSFDS YMIPTSELKP GELRLLEVDN RVVLPMEMTI
160 170 180 190 200
RMLVSSEDVL HSWAVPSLGL KTDAIPGRLN QTTLMSTRPG LYYGQCSEIC
210 220
GSNHSFMPIV LELVPLNYFE KWSASML
Length:227
Mass (Da):26,007
Last modified:November 1, 1996 - v1
Checksum:i00CD22219C23CC21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18816 Genomic DNA. Translation: AAA74568.1.
HQ332445 Genomic DNA. Translation: ADO78891.1.
JN632671 Genomic DNA. Translation: AEP21796.1.
JN632673 Genomic DNA. Translation: AEP21822.1.
KM612271 Genomic DNA. Translation: AJG02758.1.
KM612272 Genomic DNA. Translation: AJG02771.1.
KM612274 Genomic DNA. Translation: AJG02797.1.
KM612275 Genomic DNA. Translation: AJG02810.1.
KM612276 Genomic DNA. Translation: AJG02823.1.
KM612277 Genomic DNA. Translation: AJG02836.1.
KM612278 Genomic DNA. Translation: AJG02849.1.
KM612279 Genomic DNA. Translation: AJG02862.1.
RefSeqiYP_004300511.1. NC_015247.1.

Genome annotation databases

GeneIDi10322915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18816 Genomic DNA. Translation: AAA74568.1.
HQ332445 Genomic DNA. Translation: ADO78891.1.
JN632671 Genomic DNA. Translation: AEP21796.1.
JN632673 Genomic DNA. Translation: AEP21822.1.
KM612271 Genomic DNA. Translation: AJG02758.1.
KM612272 Genomic DNA. Translation: AJG02771.1.
KM612274 Genomic DNA. Translation: AJG02797.1.
KM612275 Genomic DNA. Translation: AJG02810.1.
KM612276 Genomic DNA. Translation: AJG02823.1.
KM612277 Genomic DNA. Translation: AJG02836.1.
KM612278 Genomic DNA. Translation: AJG02849.1.
KM612279 Genomic DNA. Translation: AJG02862.1.
RefSeqiYP_004300511.1. NC_015247.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10322915.

Organism-specific databases

CTDi4513.

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mammalian mitochondrial DNA evolution: a comparison of the cytochrome b and cytochrome c oxidase II genes."
    Honeycutt R.L., Nedbal M.A., Adkins R.M., Janecek L.L.
    J. Mol. Evol. 40:260-272(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome-wide polymorphism and comparative analyses in the white-tailed deer (Odocoileus virginianus): a model for conservation genomics."
    Seabury C.M., Bhattarai E.K., Taylor J.F., Viswanathan G.G., Cooper S.M., Davis D.S., Dowd S.E., Lockwood M.L., Seabury P.M.
    PLoS ONE 6:E15811-E15811(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Pattern and timing of diversification of Cetartiodactyla (Mammalia, Laurasiatheria), as revealed by a comprehensive analysis of mitochondrial genomes."
    Hassanin A., Delsuc F., Ropiquet A., Hammer C., Jansen van Vuuren B., Matthee C., Ruiz-Garcia M., Catzeflis F., Areskoug V., Nguyen T.T., Couloux A.
    C. R. Biol. 335:32-50(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MRGOv14Imported and T4887Imported.
  4. "The complete mitochondrial genomes of nine subspecies of mexican white tiled deer."
    Ambriz P., De La Rosa X.F., Sifuentes A.M., Parra M., Villa A., Chassin O., Arellano W.
    Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: OvacpCMImported, Ovcou3Imported, Ovmex31Imported, Ovoax2Imported, Ovsin17Imported, Ovtol1Imported, Ovver13Imported and Ovyuc61Imported.

Entry informationi

Entry nameiQ37585_ODOVR
AccessioniPrimary (citable) accession number: Q37585
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.