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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

nad4

Organism
Lactuca sativa (Garden lettuce)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad4Imported
Encoded oniMitochondrionImported
OrganismiLactuca sativa (Garden lettuce)Imported
Taxonomic identifieri4236 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeCichorioideaeCichorieaeLactucinaeLactuca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 29HelicalSequence analysisAdd BLAST18
Transmembranei36 – 54HelicalSequence analysisAdd BLAST19
Transmembranei80 – 107HelicalSequence analysisAdd BLAST28
Transmembranei143 – 161HelicalSequence analysisAdd BLAST19
Transmembranei173 – 194HelicalSequence analysisAdd BLAST22
Transmembranei214 – 237HelicalSequence analysisAdd BLAST24
Transmembranei244 – 265HelicalSequence analysisAdd BLAST22
Transmembranei271 – 295HelicalSequence analysisAdd BLAST25
Transmembranei307 – 328HelicalSequence analysisAdd BLAST22
Transmembranei334 – 357HelicalSequence analysisAdd BLAST24
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei453 – 472HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 422Proton_antipo_MInterPro annotationAdd BLAST283

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEHFCECYS DLSGLILCPV LGSITPLFIP NSRIRPIRLI GLCASLITFL
60 70 80 90 100
YSPVLRIQFD PSTAKSQFVE SLRWLPYENI HFYLGIDGIS LFFVILTTFL
110 120 130 140 150
IPICILVGWS GMRSYGKEYI TASLIREFLM IAVFRMLDPL LFYVLPESVL
160 170 180 190 200
IPMFIIIGVW GSRQRKIKAA YQLFLYTLLG SVFMLLAILL ILFQTGTTDL
210 220 230 240 250
QILLTTEFSE RRQIFLWIAF FASFAVKVPM VPVHIWLPEA HVEAPTAGSV
260 270 280 290 300
ILAGILLKLG TYGFLRFSIP MFPEATLCFT PFIYTLSAIA IIYTSLTTLR
310 320 330 340 350
QIDLKKIIAY SSVAHMNLVT IGMFSLNIQG IGGSILLMLS HGLVSSALFL
360 370 380 390 400
CVGVLYVRHK TRLVRYYGGL VSTMPNFSTI FFFFTLANMS LPGTSSFIGE
410 420 430 440 450
FLILVGAFQR NSLVATLAAL GMILGAAYSL WLYNRVVSGN LKPDFLHKFS
460 470 480 490
DLNGTEVFIF IPFLVGVVWM GVYPKVFPDC MHTSVSNLVQ HGKFH
Length:495
Mass (Da):55,530
Last modified:November 1, 1996 - v1
Checksum:i9CF014207A8236A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12246 Genomic DNA. Translation: AAA75278.1.
PIRiS43882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12246 Genomic DNA. Translation: AAA75278.1.
PIRiS43882.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ37544_LACSA
AccessioniPrimary (citable) accession number: Q37544
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.