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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

nad4

Organism
Allomyces macrogynus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

NADUniRule annotation, UbiquinoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.3UniRule annotation)
Gene namesi
Name:nad4Imported
Encoded oniMitochondrionImported
OrganismiAllomyces macrogynusImported
Taxonomic identifieri28583 [NCBI]
Taxonomic lineageiEukaryotaFungiBlastocladiomycotaBlastocladiomycetesBlastocladialesBlastocladiaceaeAllomyces

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2419HelicalSequence analysisAdd
BLAST
Transmembranei31 – 5020HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9728HelicalSequence analysisAdd
BLAST
Transmembranei109 – 12618HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei210 – 23223HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Transmembranei302 – 32423HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35122HelicalSequence analysisAdd
BLAST
Transmembranei358 – 37922HelicalSequence analysisAdd
BLAST
Transmembranei385 – 40319HelicalSequence analysisAdd
BLAST
Transmembranei410 – 43324HelicalSequence analysisAdd
BLAST
Transmembranei453 – 47523HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 419291Proton_antipo_MInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTLIILPL VGALIIYLGE SSFTNETRLR IALIIAGINF IISIGLWIQF
60 70 80 90 100
DENTAQFQFV EDFGSLFGQG LCHLIIGVDG ISLFFVILTS FLTIPIILTP
110 120 130 140 150
PYNGESPTAY LITLLILESM LIAVFVVLDL LLFYICFETV LIPMFLIIGI
160 170 180 190 200
WGSKVRKIMA AYHFFLYTLL GSLFMLLGII VIYYQTGTTD YQYLLAVLGT
210 220 230 240 250
AESSLTRENL LWLTFFLSFA VKVPMFPVYG WLPLAHSEAP TGGSMILAGI
260 270 280 290 300
LLKLSGYGFL RYSIPLFPNA SNYFTPFVLT LAVIGILYSI FACFRQTDLK
310 320 330 340 350
SVIAYSSISH MNIVIAAIFS DNIIGIEGAL FMMISHGIVS SALFFCVGAL
360 370 380 390 400
YDRTGTRILA YYRGLTMVMP LFSLCFFILI LNNMAVPGGI GFIGEFLCFL
410 420 430 440 450
GIFKTNPIIC LLASLSIVLG AAYNIFLTNR LLFGSLSKYF KSYNDLTRRE
460 470 480
FMILLPFVFL SILLGLCPNI ILNAIHQSCS IF
Length:482
Mass (Da):53,575
Last modified:November 1, 1996 - v1
Checksum:i41217A15F034356F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41288 Genomic DNA. Translation: AAC49242.1.
PIRiS63659.
RefSeqiNP_043741.1. NC_001715.1.

Genome annotation databases

GeneIDi801841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41288 Genomic DNA. Translation: AAC49242.1.
PIRiS63659.
RefSeqiNP_043741.1. NC_001715.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi801841.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus."
    Paquin B., Lang B.F.
    J. Mol. Biol. 255:688-701(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ37401_ALLMA
AccessioniPrimary (citable) accession number: Q37401
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.