Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q37384 (NDUS2_ACACA)

Last modified November 25, 2008. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH dehydrogenase subunit 7
Gene names
Name: NAD7
Encoded onMitochondrion
OrganismAcanthamoeba castellanii (Amoeba)
Taxonomic identifier5755 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaCentramoebidaAcanthamoebidaeAcanthamoeba

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme.

Catalytic activity

NADH + ubiquinone = NAD(+) + ubiquinol.

NADH + acceptor = NAD(+) + reduced acceptor.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 401401NADH-ubiquinone oxidoreductase 49 kDa subunit
PRO_0000118587

Sequences

Sequence LengthMass (Da)Tools
Q37384-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BA929F88024C0DF8

FASTA40146,096
        10         20         30         40         50         60 
MRKNQISPYI KTSKIKNFTM NFGPQHPAAH GVLRLILELD GELVRKADPH IGLLHRGTEK 

        70         80         90        100        110        120 
LIEYKTYIQA LPYFDRLDYV SMMSQEHAYS LAIEKLLNCN VPIRAQYIRV IYSELTRILN 

       130        140        150        160        170        180 
HILAVTTHAM DVGALTPFLW LFEEREKLME FYERVSGARM HAAYIRPGGV AQDFPLGLWN 

       190        200        210        220        230        240 
DIMQFVEQFF WRLVEVEELL NGNRIWKQRL VDVGIVTAEE ALSHGFSGVM LRGSGIAWDL 

       250        260        270        280        290        300 
RKNNPYEVYN KLNFNIPIGK NGDCYDRYLI RVYEMYESLN IIKQCLTAMP AGLIKVNDKK 

       310        320        330        340        350        360 
ITPPERTDMK YSMESLIHHF KLYSEGFNVP ENETYACVEA PKGEFGVYVV SDGSNKPYRC 

       370        380        390        400 
KIKAPGFLHL QSLNSMSKGH MIADVVTIIG TQDIVFGEID R 

« Hide

References

[1]"The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization."
Burger G., Plante I., Lonergan K.M., Gray M.W.
J. Mol. Biol. 245:522-537(1995) [PubMed: 7844823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 30010 / Neff.

Cross-references

Sequence databases

U12386 Genomic DNA. Translation: AAD11854.1.
PIRS53862.
RefSeqNP_042561.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1734056.

Family and domain databases

InterProIPR014029. NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219. NADH_DH_1_dsu.
IPR001135. NADH_UbQ_OxRdtase_49kDa.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_ACACA
AccessionPrimary (citable) accession number: Q37384
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents