Reviewed, UniProtKB/Swiss-Prot Q37384 (NDUS2_ACACA)

Names and origin

Protein names

Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH dehydrogenase subunit 7

Gene names

Name:

NAD7

Encoded on

Mitochondrion

Organism

Acanthamoeba castellanii (Amoeba)

Taxonomic identifier

5755 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Centramoebida › Acanthamoebidae › Acanthamoeba

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	NADH-ubiquinone oxidoreductase 49 kDa subunit		PRO_0000118587

Sequences

	Sequence		Length	Mass (Da)
	Q37384-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BA929F88024C0DF8	FASTA	401	46,096
	10 20 30 40 50 60 MRKNQISPYI KTSKIKNFTM NFGPQHPAAH GVLRLILELD GELVRKADPH IGLLHRGTEK 70 80 90 100 110 120 LIEYKTYIQA LPYFDRLDYV SMMSQEHAYS LAIEKLLNCN VPIRAQYIRV IYSELTRILN 130 140 150 160 170 180 HILAVTTHAM DVGALTPFLW LFEEREKLME FYERVSGARM HAAYIRPGGV AQDFPLGLWN 190 200 210 220 230 240 DIMQFVEQFF WRLVEVEELL NGNRIWKQRL VDVGIVTAEE ALSHGFSGVM LRGSGIAWDL 250 260 270 280 290 300 RKNNPYEVYN KLNFNIPIGK NGDCYDRYLI RVYEMYESLN IIKQCLTAMP AGLIKVNDKK 310 320 330 340 350 360 ITPPERTDMK YSMESLIHHF KLYSEGFNVP ENETYACVEA PKGEFGVYVV SDGSNKPYRC 370 380 390 400 KIKAPGFLHL QSLNSMSKGH MIADVVTIIG TQDIVFGEID R

References

[1]

"The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization." Burger G., Plante I., Lonergan K.M., Gray M.W. J. Mol. Biol. 245:522-537(1995) [PubMed: 7844823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 30010 / Neff.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12386 Genomic DNA. Translation: AAD11854.1.
PIR	S53862.
RefSeq	NP_042561.1.
3D structure databases
SMR	Q37384. Positions 27-401.
ModBase	Search...
Genome annotation databases
GeneID	1734056.
Enzyme and pathway databases
BRENDA	1.6.5.3. 3105. 1.6.99.3. 3105.
Family and domain databases
InterPro	IPR010219. NADH_DH_1_dsu. IPR001135. NADH_Q_OxRdtase_suD. IPR014029. NADH_UbQ_OxRdtase_49kDa_CS. [Graphical view]
Pfam	PF00346. Complex1_49kDa. 1 hit. [Graphical view]
TIGRFAMs	TIGR01962. NuoD. 1 hit.
PROSITE	PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS2_ACACA

Accession

Primary (citable) accession number: Q37384

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)