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Q37383 (NDUS3_ACACA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase subunit 9

EC=1.6.5.3
EC=1.6.99.3
Gene names
Name:NAD9
Encoded onMitochondrion
OrganismAcanthamoeba castellanii (Amoeba)
Taxonomic identifier5755 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. HAMAP-Rule MF_01357

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01357

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01357

Subunit structure

Complex I is composed of about 30 different subunits.

Subcellular location

Mitochondrion inner membrane HAMAP-Rule MF_01357.

Sequence similarities

Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentmitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 195195NADH-ubiquinone oxidoreductase subunit 9 HAMAP-Rule MF_01357
PRO_0000118644

Sequences

Sequence LengthMass (Da)Tools
Q37383 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 449A900545A0F073

FASTA19523,349
        10         20         30         40         50         60 
MGLNFFMSRK IYYIKLLTGL YKKFIKALIV KKNESNNAYL LVETANFYNL VFSLQRSSLT 

        70         80         90        100        110        120 
QFKVLNDVCI VDYPEKIDRF ELSYNLSSIK YNFRIFIKTY TSAYVPSIST LFNSANWIER 

       130        140        150        160        170        180 
ECWDMFGVFF TNHPDLRRIL TDYGFEGFPL RKDFPLTGYI EIRYDDEKAN IVYEPLELSQ 

       190 
EYRLFNFTSP WEKIK 

« Hide

References

[1]"The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization."
Burger G., Plante I., Lonergan K.M., Gray M.W.
J. Mol. Biol. 245:522-537(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 30010 / Neff.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12386 Genomic DNA. Translation: AAD11853.1.
PIRS53861.
RefSeqNP_042560.1. NC_001637.1.

3D structure databases

ProteinModelPortalQ37383.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1734055.

Family and domain databases

HAMAPMF_01357. NDH1_NuoC.
InterProIPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
IPR020396. NADH_UbQ_OxRdtase_CS.
[Graphical view]
PfamPF00329. Complex1_30kDa. 1 hit.
[Graphical view]
ProDomPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01961. NuoC_fam. 1 hit.
PROSITEPS00542. COMPLEX1_30K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS3_ACACA
AccessionPrimary (citable) accession number: Q37383
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families