Q37383 (NDUS3_ACACA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase subunit 9
EC=1.6.5.3
EC=1.6.99.3

Gene names

Name:

NAD9

Encoded on

Mitochondrion

Organism

Acanthamoeba castellanii (Amoeba)

Taxonomic identifier

5755 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Centramoebida › Acanthamoebidae › Acanthamoeba

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor.
Subunit structure	Complex I is composed of about 30 different subunits.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	NADH-ubiquinone oxidoreductase subunit 9		PRO_0000118644

Sequences

	Sequence		Length	Mass (Da)
	Q37383 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 449A900545A0F073	FASTA	195	23,349
	10 20 30 40 50 60 MGLNFFMSRK IYYIKLLTGL YKKFIKALIV KKNESNNAYL LVETANFYNL VFSLQRSSLT 70 80 90 100 110 120 QFKVLNDVCI VDYPEKIDRF ELSYNLSSIK YNFRIFIKTY TSAYVPSIST LFNSANWIER 130 140 150 160 170 180 ECWDMFGVFF TNHPDLRRIL TDYGFEGFPL RKDFPLTGYI EIRYDDEKAN IVYEPLELSQ 190 EYRLFNFTSP WEKIK

References

[1]

"The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization." Burger G., Plante I., Lonergan K.M., Gray M.W. J. Mol. Biol. 245:522-537(1995) [PubMed: 7844823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 30010 / Neff.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U12386 Genomic DNA. Translation: AAD11853.1.
PIR	S53861.
RefSeq	NP_042560.1. NC_001637.1.
3D structure databases
ProteinModelPortal	Q37383.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1734055.
Family and domain databases
InterPro	IPR010218. NADH_DH_suC. IPR001268. NADH_UbQ_OxRdtase_30kDa_su. IPR020396. NADH_UbQ_OxRdtase_CS. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS3_ACACA

Accession

Primary (citable) accession number: Q37383

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)