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Protein

ATP synthase subunit 9, mitochondrial

Gene

ATP9

Organism
Acanthamoeba castellanii (Amoeba)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63Reversibly protonated during proton transportBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit 9, mitochondrial
Alternative name(s):
Lipid-binding protein
Gene namesi
Name:ATP9
Encoded oniMitochondrion
OrganismiAcanthamoeba castellanii (Amoeba)
Taxonomic identifieri5755 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001122271 – 79ATP synthase subunit 9, mitochondrialAdd BLAST79

Proteomic databases

PRIDEiQ37377.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Structurei

3D structure databases

ProteinModelPortaliQ37377.
SMRiQ37377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiView protein in InterPro
IPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
PANTHERiPTHR10031. PTHR10031. 1 hit.
PfamiView protein in Pfam
PF00137. ATP-synt_C. 1 hit.
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiView protein in PROSITE
PS00605. ATPASE_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLEIILQS SKMIGSGLAT SGLIGAGAGV GIVFGCLILA FSRNPNLQKE
60 70
LFSYALIGFA LTEAIGLLAL VMAFLILFI
Length:79
Mass (Da):8,246
Last modified:November 1, 1996 - v1
Checksum:iD114D06E18C3AC26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12386 Genomic DNA. Translation: AAD11829.1.
PIRiS53837.
RefSeqiNP_042536.1. NC_001637.1.

Genome annotation databases

GeneIDi1734033.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiATP9_ACACA
AccessioniPrimary (citable) accession number: Q37377
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 15, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families