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Q37374

- COX3_ACACA

UniProt

Q37374 - COX3_ACACA

Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Acanthamoeba castellanii (Amoeba)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:COX3
    Encoded oniMitochondrion
    OrganismiAcanthamoeba castellanii (Amoeba)
    Taxonomic identifieri5755 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Cytochrome c oxidase subunit 3PRO_0000183726Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ37374.
    SMRiQ37374. Positions 41-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 19123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 2 hits.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q37374-1 [UniParc]FASTAAdd to Basket

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    MKLNYDFFLN KFNNVYNNDI RLVDLSNKWW YHNCRVHFAG NQKHSFHIVT    50
    RSPWPLYSSI AALMFTFGLV MHMHNYFYGN LLSLAGFFLI LLMMFVWWRD 100
    VIRESTFSGY HTKKVQQGLR LGVILFIISE VMFFFSFFWA FFHASLSPSV 150
    VLGSVWPPLG INVLNPLKIP LLNTLILLLS GLTVTWSHHV IRDKSWQKFF 200
    FSNSNNEEFK APLLDNYVIC AFALFLTVFL GLEFTVWQGY EYYKASFYIY 250
    DGVYGSTFYM TTGLHGLHVI IGTLFLIVCF FRLIDLHFIY NHHFGYEAAI 300
    WYWHFVDVVW IFLFLSIYCW GSGVDSFFK 329
    Length:329
    Mass (Da):38,914
    Last modified:November 1, 1996 - v1
    Checksum:iA6F2036F57EE8047
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12386 Genomic DNA. Translation: AAD11825.1.
    PIRiS53833.
    RefSeqiNP_042532.1. NC_001637.1.

    Genome annotation databases

    GeneIDi1734027.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12386 Genomic DNA. Translation: AAD11825.1 .
    PIRi S53833.
    RefSeqi NP_042532.1. NC_001637.1.

    3D structure databases

    ProteinModelPortali Q37374.
    SMRi Q37374. Positions 41-322.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1734027.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization."
      Burger G., Plante I., Lonergan K.M., Gray M.W.
      J. Mol. Biol. 245:522-537(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 30010 / Neff.

    Entry informationi

    Entry nameiCOX3_ACACA
    AccessioniPrimary (citable) accession number: Q37374
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3