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Q37374 (COX3_ACACA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COX3
Encoded onMitochondrion
OrganismAcanthamoeba castellanii (Amoeba)
Taxonomic identifier5755 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaCentramoebidaAcanthamoebidaeAcanthamoeba

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Cytochrome c oxidase subunit 3
PRO_0000183726

Regions

Transmembrane53 – 7321Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane169 – 19123Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane269 – 28921Helical; Potential
Transmembrane298 – 31821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q37374 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A6F2036F57EE8047

FASTA32938,914
        10         20         30         40         50         60 
MKLNYDFFLN KFNNVYNNDI RLVDLSNKWW YHNCRVHFAG NQKHSFHIVT RSPWPLYSSI 

        70         80         90        100        110        120 
AALMFTFGLV MHMHNYFYGN LLSLAGFFLI LLMMFVWWRD VIRESTFSGY HTKKVQQGLR 

       130        140        150        160        170        180 
LGVILFIISE VMFFFSFFWA FFHASLSPSV VLGSVWPPLG INVLNPLKIP LLNTLILLLS 

       190        200        210        220        230        240 
GLTVTWSHHV IRDKSWQKFF FSNSNNEEFK APLLDNYVIC AFALFLTVFL GLEFTVWQGY 

       250        260        270        280        290        300 
EYYKASFYIY DGVYGSTFYM TTGLHGLHVI IGTLFLIVCF FRLIDLHFIY NHHFGYEAAI 

       310        320 
WYWHFVDVVW IFLFLSIYCW GSGVDSFFK 

« Hide

References

[1]"The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization."
Burger G., Plante I., Lonergan K.M., Gray M.W.
J. Mol. Biol. 245:522-537(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 30010 / Neff.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12386 Genomic DNA. Translation: AAD11825.1.
PIRS53833.
RefSeqNP_042532.1. NC_001637.1.

3D structure databases

ProteinModelPortalQ37374.
SMRQ37374. Positions 41-322.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1734027.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 2 hits.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_ACACA
AccessionPrimary (citable) accession number: Q37374
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families