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Q37374

- COX3_ACACA

UniProt

Q37374 - COX3_ACACA

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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Acanthamoeba castellanii (Amoeba)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Encoded oniMitochondrion
OrganismiAcanthamoeba castellanii (Amoeba)
Taxonomic identifieri5755 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 19123HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Cytochrome c oxidase subunit 3PRO_0000183726Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ37374.
SMRiQ37374. Positions 41-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 2 hits.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37374-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLNYDFFLN KFNNVYNNDI RLVDLSNKWW YHNCRVHFAG NQKHSFHIVT
60 70 80 90 100
RSPWPLYSSI AALMFTFGLV MHMHNYFYGN LLSLAGFFLI LLMMFVWWRD
110 120 130 140 150
VIRESTFSGY HTKKVQQGLR LGVILFIISE VMFFFSFFWA FFHASLSPSV
160 170 180 190 200
VLGSVWPPLG INVLNPLKIP LLNTLILLLS GLTVTWSHHV IRDKSWQKFF
210 220 230 240 250
FSNSNNEEFK APLLDNYVIC AFALFLTVFL GLEFTVWQGY EYYKASFYIY
260 270 280 290 300
DGVYGSTFYM TTGLHGLHVI IGTLFLIVCF FRLIDLHFIY NHHFGYEAAI
310 320
WYWHFVDVVW IFLFLSIYCW GSGVDSFFK
Length:329
Mass (Da):38,914
Last modified:November 1, 1996 - v1
Checksum:iA6F2036F57EE8047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12386 Genomic DNA. Translation: AAD11825.1.
PIRiS53833.
RefSeqiNP_042532.1. NC_001637.1.

Genome annotation databases

GeneIDi1734027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12386 Genomic DNA. Translation: AAD11825.1 .
PIRi S53833.
RefSeqi NP_042532.1. NC_001637.1.

3D structure databases

ProteinModelPortali Q37374.
SMRi Q37374. Positions 41-322.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1734027.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 2 hits.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization."
    Burger G., Plante I., Lonergan K.M., Gray M.W.
    J. Mol. Biol. 245:522-537(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 30010 / Neff.

Entry informationi

Entry nameiCOX3_ACACA
AccessioniPrimary (citable) accession number: Q37374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3