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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Acanthamoeba castellanii (Amoeba)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 5
Gene namesi
Name:ND5
Synonyms:NAD5
Encoded oniMitochondrion
OrganismiAcanthamoeba castellanii (Amoeba)
Taxonomic identifieri5755 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei108 – 127HelicalSequence analysisAdd BLAST20
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei311 – 329HelicalSequence analysisAdd BLAST19
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Transmembranei624 – 644HelicalSequence analysisAdd BLAST21
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001180501 – 675NADH-ubiquinone oxidoreductase chain 5Add BLAST675

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLLPLLFPL LNLFISCILG KFLGKRVLFV LVINMLFSAI FSFWIFYEVG
60 70 80 90 100
INKSVCYIDL GPWFHIGLLK LNWLFLFDSI TSVMLVLVVF VSLLVHLYSI
110 120 130 140 150
DYMSGDPHII RFLGYLSLFT FFMLMLVTSG NFVQLFLGWE GVGLSSYLLI
160 170 180 190 200
NFWYTRIQAN KSAMKAIIVN RFGDFGIYFS LLVIFFFFKS FDFGVVFNLV
210 220 230 240 250
QFLDTQPRMS FLGFSLNRVD LIVIFLFLGA IGKSAQLGLH TWLPDAMEGP
260 270 280 290 300
TPVSALIHAA TMVTAGVFVL IRSSPILEYS STGLFLVSLI GGLTALFAGT
310 320 330 340 350
VGLVQYDIKK VIAYSTCSQL GYMFFACGMS NYSVGLFHLF NHGFFKALLF
360 370 380 390 400
LGAGSVIHAL LDEQDMRKMG GLIKLMPLTY VAILVGSLSL TGFPFLTGFY
410 420 430 440 450
SKEVVLEIAF SKFSINSFFI YWLGVFAAFI TSFYSIRLMY LVFFARPNSH
460 470 480 490 500
ARAVNSSHES SSFIFYVLAF LGFLSIFIGF IFKDLFIGLG TDFWANSIFN
510 520 530 540 550
LYVNSDILYA EFLDYYYKLI PLVFSIVGLF FSLFVYFVIY DYTVFVVKNK
560 570 580 590 600
FFRYAYFFLA KKWYFDLLYN NIFVFNLLSS FYLLTFKIID RGLIELFGPL
610 620 630 640 650
SFVRLINKSS IIFSSFQTGF LYNYIFVVLL GLMFFIKLTS SLFFPSFNSF
660 670
FNFGLFICLL SLIIFLSFGN KKQNI
Length:675
Mass (Da):77,244
Last modified:November 1, 1996 - v1
Checksum:iDE2419E4C04630B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12386 Genomic DNA. Translation: AAD11823.1.
PIRiS53831.
RefSeqiNP_042530.1. NC_001637.1.

Genome annotation databases

GeneIDi1734025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12386 Genomic DNA. Translation: AAD11823.1.
PIRiS53831.
RefSeqiNP_042530.1. NC_001637.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1734025.

Family and domain databases

InterProiIPR010934. NADH_DH_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF06455. NADH5_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_ACACA
AccessioniPrimary (citable) accession number: Q37372
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 16, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.