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Q37370

- COX1_ACACA

UniProt

Q37370 - COX1_ACACA

Protein

Cytochrome c oxidase subunit 1+2

Gene

COX1/2

Organism
Acanthamoeba castellanii (Amoeba)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751Iron (heme A axial ligand)Curated
    Metal bindingi254 – 2541Copper BCurated
    Metal bindingi258 – 2581Copper BCurated
    Metal bindingi303 – 3031Copper BCurated
    Metal bindingi304 – 3041Copper BCurated
    Metal bindingi389 – 3891Iron (heme A3 axial ligand)Curated
    Metal bindingi391 – 3911Iron (heme A axial ligand)Curated
    Metal bindingi801 – 8011Copper ACurated
    Metal bindingi836 – 8361Copper ACurated
    Metal bindingi840 – 8401Copper ACurated
    Metal bindingi844 – 8441Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I+II
    Gene namesi
    Name:COX1/2
    Encoded oniMitochondrion
    OrganismiAcanthamoeba castellanii (Amoeba)
    Taxonomic identifieri5755 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Cytochrome c oxidase subunit 1+2PRO_0000183275Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki254 ↔ 2581'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Proteomic databases

    PRIDEiQ37370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ37370.
    SMRiQ37370. Positions 16-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei469 – 48921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei536 – 55621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei585 – 60521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei656 – 67621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei845 – 86521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 474474COX1Add
    BLAST
    Regioni475 – 843369COX2Add
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
    In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    1.20.210.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR000883. COX1.
    IPR008972. Cupredoxin.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    PF00116. COX2. 2 hits.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF49503. SSF49503. 2 hits.
    SSF81442. SSF81442. 1 hit.
    SSF81464. SSF81464. 2 hits.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q37370-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINRLLNNLT SFFTDNRWLF STNHKDIGTL YLIFGGFSGI IGTIFSMIIR    50
    LELAAPGSQI LSGNSQLYNV IITAHAFVMI FFFVMPVMIG GFGNWFVPLM 100
    IGAPDMAFPR LNNISFWLLP PSLFLLLCSS LVEFGAGTGW TVYPPLSSIV 150
    AHSGGSVDLA IFSLHLAGIS SLLGAINFIT TIFNMRVPGL SMHKLPLFVW 200
    SVLITAFLLL FSLPVLAGAI TMLLTDRNFN TSFFDPSGGG DPILYQHLFW 250
    FFGHPEVYIL ILPAFGIVSQ IIGTFSNKSI FGYIGMVYAM LSIAVLGFIV 300
    WAHHMYTVGL DVDTRAYFTA ATMMIAVPTG IKIFSWIATL WGGQIVRKTP 350
    LLFVIGFLIL FTLGGLTGIV LSNAGLDIML HDTYYVVAHF HYVLSMGAVF 400
    AFFAGFYYWF WKISGYTYNE MYGNVHFWLM FIGVNLTFFP MHFVGLAGMP 450
    RRIPDYPDNY YYWNILSSFG SIISSVSVIV FFYLIYLAFN NNNTPKLIKL 500
    VHSIFAPYIN TLSKNLLTFA SIKSTSDSSF FKFSKFFIFF MVSLSVLFIF 550
    YDSLLCLNDH TNSWKIGFQD PTTPIAYGII KLHDHILFFL AVILFVVGYL 600
    LLSTYKKFYY GSLNNDLPES KRISLFDTLI NTYKENLSFN VTNRTYNINH 650
    GTTIEIIWTI LPAFILLFIA VPSFALLYAM DEIIDPVLTV KVIGHQWYWS 700
    YEYSDYSVVY SNRMLDYDSI DRFAAMEMMY KGMGYLKDRS LLSYLYIPMV 750
    IPETTIKFDS YMIHEAELNL GDLRLLKTDM PLFLPKNTHI RLLITSSDVL 800
    HSWAVPSFGV KVDAVPGRLN QTSLYLKNTG TFYGQCSELC GVNHAFMPIE 850
    VYVVNPVYFY NYVYIYFKNF NLI 873
    Length:873
    Mass (Da):99,214
    Last modified:November 1, 1996 - v1
    Checksum:i0BC820F0162B8EB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12386 Genomic DNA. Translation: AAD11820.1.
    PIRiS53828.
    RefSeqiNP_042527.1. NC_001637.1.

    Genome annotation databases

    GeneIDi1734020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12386 Genomic DNA. Translation: AAD11820.1 .
    PIRi S53828.
    RefSeqi NP_042527.1. NC_001637.1.

    3D structure databases

    ProteinModelPortali Q37370.
    SMRi Q37370. Positions 16-489.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q37370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1734020.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    1.20.210.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR000883. COX1.
    IPR008972. Cupredoxin.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    PF00116. COX2. 2 hits.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF49503. SSF49503. 2 hits.
    SSF81442. SSF81442. 1 hit.
    SSF81464. SSF81464. 2 hits.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization."
      Burger G., Plante I., Lonergan K.M., Gray M.W.
      J. Mol. Biol. 245:522-537(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 30010 / Neff.
    2. "Expression of a continuous open reading frame encoding subunits 1 and 2 of cytochrome c oxidase in the mitochondrial DNA of Acanthamoeba castellanii."
      Lonergan K.M., Gray M.W.
      J. Mol. Biol. 257:1019-1030(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_ACACA
    AccessioniPrimary (citable) accession number: Q37370
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3