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Protein

Cytochrome c oxidase subunit 1+2

Gene

COX1/2

Organism
Acanthamoeba castellanii (Amoeba)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Iron (heme A axial ligand)Curated1
Metal bindingi254Copper BCurated1
Metal bindingi258Copper BCurated1
Metal bindingi303Copper BCurated1
Metal bindingi304Copper BCurated1
Metal bindingi389Iron (heme A3 axial ligand)Curated1
Metal bindingi391Iron (heme A axial ligand)Curated1
Metal bindingi801Copper ACurated1
Metal bindingi836Copper ACurated1
Metal bindingi840Copper ACurated1
Metal bindingi844Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:COX1/2
Encoded oniMitochondrion
OrganismiAcanthamoeba castellanii (Amoeba)
Taxonomic identifieri5755 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Transmembranei656 – 676HelicalSequence analysisAdd BLAST21
Transmembranei845 – 865HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832751 – 873Cytochrome c oxidase subunit 1+2Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki254 ↔ 2581'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ37370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 474COX1Add BLAST474
Regioni475 – 843COX2Add BLAST369

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
cd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
2.60.40.420, 2 hits
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PANTHERiPTHR10422 PTHR10422, 2 hits
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PF00116 COX2, 2 hits
PF02790 COX2_TM, 2 hits
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF49503 SSF49503, 2 hits
SSF81442 SSF81442, 1 hit
SSF81464 SSF81464, 2 hits
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q37370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINRLLNNLT SFFTDNRWLF STNHKDIGTL YLIFGGFSGI IGTIFSMIIR
60 70 80 90 100
LELAAPGSQI LSGNSQLYNV IITAHAFVMI FFFVMPVMIG GFGNWFVPLM
110 120 130 140 150
IGAPDMAFPR LNNISFWLLP PSLFLLLCSS LVEFGAGTGW TVYPPLSSIV
160 170 180 190 200
AHSGGSVDLA IFSLHLAGIS SLLGAINFIT TIFNMRVPGL SMHKLPLFVW
210 220 230 240 250
SVLITAFLLL FSLPVLAGAI TMLLTDRNFN TSFFDPSGGG DPILYQHLFW
260 270 280 290 300
FFGHPEVYIL ILPAFGIVSQ IIGTFSNKSI FGYIGMVYAM LSIAVLGFIV
310 320 330 340 350
WAHHMYTVGL DVDTRAYFTA ATMMIAVPTG IKIFSWIATL WGGQIVRKTP
360 370 380 390 400
LLFVIGFLIL FTLGGLTGIV LSNAGLDIML HDTYYVVAHF HYVLSMGAVF
410 420 430 440 450
AFFAGFYYWF WKISGYTYNE MYGNVHFWLM FIGVNLTFFP MHFVGLAGMP
460 470 480 490 500
RRIPDYPDNY YYWNILSSFG SIISSVSVIV FFYLIYLAFN NNNTPKLIKL
510 520 530 540 550
VHSIFAPYIN TLSKNLLTFA SIKSTSDSSF FKFSKFFIFF MVSLSVLFIF
560 570 580 590 600
YDSLLCLNDH TNSWKIGFQD PTTPIAYGII KLHDHILFFL AVILFVVGYL
610 620 630 640 650
LLSTYKKFYY GSLNNDLPES KRISLFDTLI NTYKENLSFN VTNRTYNINH
660 670 680 690 700
GTTIEIIWTI LPAFILLFIA VPSFALLYAM DEIIDPVLTV KVIGHQWYWS
710 720 730 740 750
YEYSDYSVVY SNRMLDYDSI DRFAAMEMMY KGMGYLKDRS LLSYLYIPMV
760 770 780 790 800
IPETTIKFDS YMIHEAELNL GDLRLLKTDM PLFLPKNTHI RLLITSSDVL
810 820 830 840 850
HSWAVPSFGV KVDAVPGRLN QTSLYLKNTG TFYGQCSELC GVNHAFMPIE
860 870
VYVVNPVYFY NYVYIYFKNF NLI
Length:873
Mass (Da):99,214
Last modified:November 1, 1996 - v1
Checksum:i0BC820F0162B8EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12386 Genomic DNA Translation: AAD11820.1
PIRiS53828
RefSeqiNP_042527.1, NC_001637.1

Genome annotation databases

GeneIDi1734020

Similar proteinsi

Entry informationi

Entry nameiCOX1_ACACA
AccessioniPrimary (citable) accession number: Q37370
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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