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Q37370

- COX1_ACACA

UniProt

Q37370 - COX1_ACACA

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Protein

Cytochrome c oxidase subunit 1+2

Gene
COX1/2
Organism
Acanthamoeba castellanii (Amoeba)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi75 – 751Iron (heme A axial ligand) Inferred
Metal bindingi254 – 2541Copper B Inferred
Metal bindingi258 – 2581Copper B Inferred
Metal bindingi303 – 3031Copper B Inferred
Metal bindingi304 – 3041Copper B Inferred
Metal bindingi389 – 3891Iron (heme A3 axial ligand) Inferred
Metal bindingi391 – 3911Iron (heme A axial ligand) Inferred
Metal bindingi801 – 8011Copper A Inferred
Metal bindingi836 – 8361Copper A Inferred
Metal bindingi840 – 8401Copper A Inferred
Metal bindingi844 – 8441Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1+2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I+II
Gene namesi
Name:COX1/2
Encoded oniMitochondrion
OrganismiAcanthamoeba castellanii (Amoeba)
Taxonomic identifieri5755 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaDiscoseaLongamoebiaCentramoebidaAcanthamoebidaeAcanthamoeba

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921Helical; Reviewed predictionAdd
BLAST
Transmembranei70 – 9021Helical; Reviewed predictionAdd
BLAST
Transmembranei91 – 11121Helical; Reviewed predictionAdd
BLAST
Transmembranei114 – 13421Helical; Reviewed predictionAdd
BLAST
Transmembranei159 – 17921Helical; Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Reviewed predictionAdd
BLAST
Transmembranei248 – 26821Helical; Reviewed predictionAdd
BLAST
Transmembranei280 – 30021Helical; Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Reviewed predictionAdd
BLAST
Transmembranei351 – 37121Helical; Reviewed predictionAdd
BLAST
Transmembranei390 – 41021Helical; Reviewed predictionAdd
BLAST
Transmembranei427 – 44721Helical; Reviewed predictionAdd
BLAST
Transmembranei469 – 48921Helical; Reviewed predictionAdd
BLAST
Transmembranei536 – 55621Helical; Reviewed predictionAdd
BLAST
Transmembranei585 – 60521Helical; Reviewed predictionAdd
BLAST
Transmembranei656 – 67621Helical; Reviewed predictionAdd
BLAST
Transmembranei845 – 86521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Cytochrome c oxidase subunit 1+2PRO_0000183275Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki254 ↔ 2581'-histidyl-3'-tyrosine (His-Tyr) By similarity

Proteomic databases

PRIDEiQ37370.

Structurei

3D structure databases

ProteinModelPortaliQ37370.
SMRiQ37370. Positions 16-489.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 474474COX1Add
BLAST
Regioni475 – 843369COX2Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
PF00116. COX2. 2 hits.
PF02790. COX2_TM. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 2 hits.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q37370-1 [UniParc]FASTAAdd to Basket

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MINRLLNNLT SFFTDNRWLF STNHKDIGTL YLIFGGFSGI IGTIFSMIIR    50
LELAAPGSQI LSGNSQLYNV IITAHAFVMI FFFVMPVMIG GFGNWFVPLM 100
IGAPDMAFPR LNNISFWLLP PSLFLLLCSS LVEFGAGTGW TVYPPLSSIV 150
AHSGGSVDLA IFSLHLAGIS SLLGAINFIT TIFNMRVPGL SMHKLPLFVW 200
SVLITAFLLL FSLPVLAGAI TMLLTDRNFN TSFFDPSGGG DPILYQHLFW 250
FFGHPEVYIL ILPAFGIVSQ IIGTFSNKSI FGYIGMVYAM LSIAVLGFIV 300
WAHHMYTVGL DVDTRAYFTA ATMMIAVPTG IKIFSWIATL WGGQIVRKTP 350
LLFVIGFLIL FTLGGLTGIV LSNAGLDIML HDTYYVVAHF HYVLSMGAVF 400
AFFAGFYYWF WKISGYTYNE MYGNVHFWLM FIGVNLTFFP MHFVGLAGMP 450
RRIPDYPDNY YYWNILSSFG SIISSVSVIV FFYLIYLAFN NNNTPKLIKL 500
VHSIFAPYIN TLSKNLLTFA SIKSTSDSSF FKFSKFFIFF MVSLSVLFIF 550
YDSLLCLNDH TNSWKIGFQD PTTPIAYGII KLHDHILFFL AVILFVVGYL 600
LLSTYKKFYY GSLNNDLPES KRISLFDTLI NTYKENLSFN VTNRTYNINH 650
GTTIEIIWTI LPAFILLFIA VPSFALLYAM DEIIDPVLTV KVIGHQWYWS 700
YEYSDYSVVY SNRMLDYDSI DRFAAMEMMY KGMGYLKDRS LLSYLYIPMV 750
IPETTIKFDS YMIHEAELNL GDLRLLKTDM PLFLPKNTHI RLLITSSDVL 800
HSWAVPSFGV KVDAVPGRLN QTSLYLKNTG TFYGQCSELC GVNHAFMPIE 850
VYVVNPVYFY NYVYIYFKNF NLI 873
Length:873
Mass (Da):99,214
Last modified:November 1, 1996 - v1
Checksum:i0BC820F0162B8EB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12386 Genomic DNA. Translation: AAD11820.1.
PIRiS53828.
RefSeqiNP_042527.1. NC_001637.1.

Genome annotation databases

GeneIDi1734020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12386 Genomic DNA. Translation: AAD11820.1 .
PIRi S53828.
RefSeqi NP_042527.1. NC_001637.1.

3D structure databases

ProteinModelPortali Q37370.
SMRi Q37370. Positions 16-489.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q37370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1734020.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
1.20.210.10. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR000883. COX1.
IPR008972. Cupredoxin.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
PF00116. COX2. 2 hits.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81442. SSF81442. 1 hit.
SSF81464. SSF81464. 2 hits.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mitochondrial DNA of the amoeboid protozoon, Acanthamoeba castellanii: complete sequence, gene content and genome organization."
    Burger G., Plante I., Lonergan K.M., Gray M.W.
    J. Mol. Biol. 245:522-537(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 30010 / Neff.
  2. "Expression of a continuous open reading frame encoding subunits 1 and 2 of cytochrome c oxidase in the mitochondrial DNA of Acanthamoeba castellanii."
    Lonergan K.M., Gray M.W.
    J. Mol. Biol. 257:1019-1030(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_ACACA
AccessioniPrimary (citable) accession number: Q37370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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