Reviewed, UniProtKB/Swiss-Prot Q37165 (NU1C_ARATH)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:	ndhA
Ordered Locus Names:	AtCg01100

Encoded on

Plastid; Chloroplast

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000117506
Regions
	Transmembrane	27 – 47	21	Potential
	Transmembrane	98 – 118	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	165 – 185	21	Potential
	Transmembrane	203 – 223	21	Potential
	Transmembrane	253 – 273	21	Potential
	Transmembrane	297 – 317	21	Potential
	Transmembrane	340 – 360	21	Potential
Experimental info
	Sequence conflict	14	1	I → F in BAA84442. Ref.2
	Sequence conflict	226	1	S → C in BAA84442. Ref.2
	Sequence conflict	283	1	S → I in BAA84442. Ref.2
	Sequence conflict	299	1	A → G in BAA84442. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q37165-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2FBBE46F627A2F03	FASTA	360	39,959
	10 20 30 40 50 60 MIIYATAVQT INSIVKLESL KEVYGLIWIF VPIFSLVLGI ITGVLVIVWL EREISAGIQQ 70 80 90 100 110 120 RIGPEYAGPL GILQALADGT KLLFKENLRP SRGNTPLFSI GPSIAVISIL LSYSVIPFSN 130 140 150 160 170 180 HLVLADLNIG IFLWIAISSI APIGLLMSGY GSNNKYSFLG GLRAAAQSIS YEIPLTLCVL 190 200 210 220 230 240 SISLLSNSLS TVDIVEAQSK YGFWGWNLWR QPIGFIIFLI SSLAESERLP FDLPEAEEEL 250 260 270 280 290 300 IAGYQTEYSG IKFGLFYVAS YLNLLISSLF VTVLYLGGWN ISSPYISILE LFQRDQIFAT 310 320 330 340 350 360 TIGIFITLAK TYLFLFVSIA TRWTLPRLRM DQLLNLGWKF LLPISLGNLL LTTSFQLFSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Schuster W. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. C24.
[2]	"Complete structure of the chloroplast genome of Arabidopsis thaliana." Sato S., Nakamura Y., Kaneko T., Asamizu E., Tabata S. DNA Res. 6:283-290(1999) [PubMed: 10574454] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X98298 Genomic DNA. Translation: CAA66944.1. AP000423 Genomic DNA. Translation: BAA84442.1.
IPI	IPI00525846.
RefSeq	NP_051114.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q37165.
Genome annotation databases
GeneID	844804.
GenomeReviews	Gene locus ATCG01100 in contig AP000423_GR.
KEGG	ath:ArthCp079.
Organism-specific databases
TAIR	AtCg01100.
Gene expression databases
GermOnline	ATCG01100. Arabidopsis thaliana.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_ARATH

Accession

Primary (citable) accession number: Q37165

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)