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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

ND5

Organism
Wickerhamomyces canadensis (Yeast) (Pichia canadensis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5 (EC:1.6.5.3)
Gene namesi
Name:ND5
Encoded oniMitochondrion
OrganismiWickerhamomyces canadensis (Yeast) (Pichia canadensis)
Taxonomic identifieri1156965 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 23HelicalSequence analysisAdd BLAST20
Transmembranei30 – 49HelicalSequence analysisAdd BLAST20
Transmembranei78 – 100HelicalSequence analysisAdd BLAST23
Transmembranei112 – 129HelicalSequence analysisAdd BLAST18
Transmembranei133 – 155HelicalSequence analysisAdd BLAST23
Transmembranei167 – 189HelicalSequence analysisAdd BLAST23
Transmembranei199 – 221HelicalSequence analysisAdd BLAST23
Transmembranei234 – 256HelicalSequence analysisAdd BLAST23
Transmembranei271 – 293HelicalSequence analysisAdd BLAST23
Transmembranei300 – 322HelicalSequence analysisAdd BLAST23
Transmembranei327 – 349HelicalSequence analysisAdd BLAST23
Transmembranei361 – 383HelicalSequence analysisAdd BLAST23
Transmembranei398 – 420HelicalSequence analysisAdd BLAST23
Transmembranei466 – 488HelicalSequence analysisAdd BLAST23
Transmembranei517 – 539HelicalSequence analysisAdd BLAST23
Transmembranei546 – 568HelicalSequence analysisAdd BLAST23
Transmembranei594 – 616HelicalSequence analysisAdd BLAST23
Transmembranei623 – 642HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001181331 – 644NADH-ubiquinone oxidoreductase chain 5Add BLAST644

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

Q37024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILFITLPLL NVIISGLLSR YIGVNNIKRL NIINLFIILI LLIYYYINII
60 70 80 90 100
KTDNEYTLKI IEWINIEYLN INYSFNLDLL SITMLIPIIL ISLIVNIFAW
110 120 130 140 150
EYMKDDSHNP RFYTYLALFT LFMIILVLGD NYLILFLGWE YIGIASFLLI
160 170 180 190 200
GFWYNNIDNI KSSLNALFIN KIGDIFFIIA LIYLIYIYKS LNYSLIFSLV
210 220 230 240 250
SYINIDINNI IILCLVIAAS AKSAQFGLHN WLIWAMAGPT PVSVLLHAAT
260 270 280 290 300
LVIAGIYLLM RSSPILENCP NILLFNLWLG AITSLISGLI AINSNDIKRI
310 320 330 340 350
IALSTMSQLG IMFISIGLSS YNLTLYHVLC HSLYKALLFI CAGTIIHSLN
360 370 380 390 400
NELQDIRFMG GLLIYMPITY ICMLIGSLSL MGLPSLTGYY SKDIIIESSI
410 420 430 440 450
GIFTISGLII YWLVVLSSLL TNIYILKLIY YSFINIPQLN KYIYNSLSLN
460 470 480 490 500
NTYSLPFNFK FNFDKSWMAI ICMIILSIGS LFIGYLLQDI YLGQGNSING
510 520 530 540 550
LFIYPNNLNL IETHFAINIY YKWIPIFNIF ISILLIIYLY EFNYKLLYIY
560 570 580 590 600
NNPLFYNFYI LFNTRFLFDQ ILNNYIIRYT LYLSKSLNSL LDKGFLYTLG
610 620 630 640
PNGLNYLLNL LSFNIIKFNT HLFNHYLIYI SFSLLLFIYL QFDL
Length:644
Mass (Da):74,560
Last modified:March 1, 2001 - v2
Checksum:iC1E306720DB4816A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16253 Genomic DNA. Translation: BAA03779.2.
D31785 Genomic DNA. Translation: BAA06571.2.
PIRiS44478.
RefSeqiNP_038216.1. NC_001762.1.

Genome annotation databases

GeneIDi800543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16253 Genomic DNA. Translation: BAA03779.2.
D31785 Genomic DNA. Translation: BAA06571.2.
PIRiS44478.
RefSeqiNP_038216.1. NC_001762.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi800543.

Family and domain databases

InterProiIPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU5M_WICCA
AccessioniPrimary (citable) accession number: Q37024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: September 16, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.