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Q36860

- COX3_SALSA

UniProt

Q36860 - COX3_SALSA

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Protein

Cytochrome c oxidase subunit 3

Gene

mt-co3

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:mt-co3
Synonyms:coiii, coxiii, mtco3
Encoded oniMitochondrion
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence AnalysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183849Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ36860.
SMRiQ36860. Positions 1-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016686.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q36860-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHQAHAYHM VDPSPWPLTG AIAALLLTSG TAVWFHFHSL TLLTMGNILL
60 70 80 90 100
LLTMYQWWRD IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA
110 120 130 140 150
FYHSSLSPTP ELGGCWPPTG IITLDPFEVP LLNTAVLLAS GVTVTWAHHS
160 170 180 190 200
IMEGERKQTI QALTLTILLG FYFTFLQGME YYEAPFTIAD GVYGSTFFVA
210 220 230 240 250
TGFHGLHVII GSTFLAICLL RQIQYHFTSE HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,796
Last modified:May 30, 2000 - v2
Checksum:i0E114F391B93C55A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351A → S(PubMed:8000479)Curated
Sequence conflicti135 – 1351A → S1 PublicationCurated
Sequence conflicti140 – 1401S → L(PubMed:2744446)Curated
Sequence conflicti158 – 1581Q → R(PubMed:8000479)Curated
Sequence conflicti158 – 1581Q → R1 PublicationCurated
Sequence conflicti159 – 1591T → M(PubMed:2744446)Curated
Sequence conflicti164 – 1641T → L(PubMed:2744446)Curated
Sequence conflicti183 – 1842EA → QS(PubMed:2744446)Curated
Sequence conflicti192 – 1932VY → YT(PubMed:2744446)Curated
Sequence conflicti216 – 2161A → T(PubMed:2744446)Curated
Sequence conflicti222 – 2254QIQY → NSMF(PubMed:2744446)Curated
Sequence conflicti230 – 2301E → K(PubMed:2744446)Curated
Sequence conflicti237 – 2371A → L(PubMed:8000479)Curated
Sequence conflicti237 – 2371A → L1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04502 Genomic DNA. Translation: AAA62409.1.
D84148 Genomic DNA. Translation: BAA20158.1.
U12143 Genomic DNA. Translation: AAD04739.1.
AF133701 Genomic DNA. Translation: AAF61384.1.
PIRiT09953.
RefSeqiNP_008451.1. NC_001960.1.

Genome annotation databases

GeneIDi808307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04502 Genomic DNA. Translation: AAA62409.1 .
D84148 Genomic DNA. Translation: BAA20158.1 .
U12143 Genomic DNA. Translation: AAD04739.1 .
AF133701 Genomic DNA. Translation: AAF61384.1 .
PIRi T09953.
RefSeqi NP_008451.1. NC_001960.1.

3D structure databases

ProteinModelPortali Q36860.
SMRi Q36860. Positions 1-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808307.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

HOVERGENi HBG016686.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the Atlantic salmon (Salmo salar) cytochrome c oxidase subunit III gene (coxIII) and analysis of coxIII expression during parr-smolt transformation."
    Hardiman G., Byrnes L., Peden J., Wolff J., Gannon F.
    Mol. Mar. Biol. Biotechnol. 3:210-216(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Isolation of Atlantic Salmon (Salmo salar) cytochrome c oxidase subunit II gene (coxII)."
    Hardiman G.T., Wolff J., Peden J., Gannon F.
    J. Appl. Ichthyol. 10:64-68(1994)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Kidney.
  3. "Mitochondrial DNA sequence analysis of the masu salmon -- phylogeny in the genus Oncorhynchus."
    Oohara I., Sawano K., Okazaki T.
    Mol. Phylogenet. Evol. 7:71-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo salar."
    Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.
    Gene 239:237-242(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  5. "The complete mitochondrial genome sequence of a teleost, Salmo salar, and comparisons with other salmoniformes."
    Arnason U., Johnsson E., Rasmussen A.S.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Organisation of the mitochondrial genome from Atlantic salmon (Salmo salar)."
    Davidson W.S., Birt T.P., Green J.M.
    Genome 32:340-342(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_SALSA
AccessioniPrimary (citable) accession number: Q36860
Secondary accession number(s): O03380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3