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Q36860 (COX3_SALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt-co3
Synonyms:coiii, coxiii, mtco3
Encoded onMitochondrion
OrganismSalmo salar (Atlantic salmon)
Taxonomic identifier8030 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salmo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183849

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane32 – 5221Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Experimental info

Sequence conflict1351A → S Ref.1
Sequence conflict1351A → S Ref.2
Sequence conflict1401S → L Ref.6
Sequence conflict1581Q → R Ref.1
Sequence conflict1581Q → R Ref.2
Sequence conflict1591T → M Ref.6
Sequence conflict1641T → L Ref.6
Sequence conflict183 – 1842EA → QS Ref.6
Sequence conflict192 – 1932VY → YT Ref.6
Sequence conflict2161A → T Ref.6
Sequence conflict222 – 2254QIQY → NSMF Ref.6
Sequence conflict2301E → K Ref.6
Sequence conflict2371A → L Ref.1
Sequence conflict2371A → L Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q36860 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 0E114F391B93C55A

FASTA26129,796
        10         20         30         40         50         60 
MAHQAHAYHM VDPSPWPLTG AIAALLLTSG TAVWFHFHSL TLLTMGNILL LLTMYQWWRD 

        70         80         90        100        110        120 
IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA FYHSSLSPTP ELGGCWPPTG 

       130        140        150        160        170        180 
IITLDPFEVP LLNTAVLLAS GVTVTWAHHS IMEGERKQTI QALTLTILLG FYFTFLQGME 

       190        200        210        220        230        240 
YYEAPFTIAD GVYGSTFFVA TGFHGLHVII GSTFLAICLL RQIQYHFTSE HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S

« Hide

References

[1]"Cloning and sequencing of the Atlantic salmon (Salmo salar) cytochrome c oxidase subunit III gene (coxIII) and analysis of coxIII expression during parr-smolt transformation."
Hardiman G., Byrnes L., Peden J., Wolff J., Gannon F.
Mol. Mar. Biol. Biotechnol. 3:210-216(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Isolation of Atlantic Salmon (Salmo salar) cytochrome c oxidase subunit II gene (coxII)."
Hardiman G.T., Wolff J., Peden J., Gannon F.
J. Appl. Ichthyol. 10:64-68(1994)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Kidney.
[3]"Mitochondrial DNA sequence analysis of the masu salmon -- phylogeny in the genus Oncorhynchus."
Oohara I., Sawano K., Okazaki T.
Mol. Phylogenet. Evol. 7:71-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo salar."
Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.
Gene 239:237-242(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[5]"The complete mitochondrial genome sequence of a teleost, Salmo salar, and comparisons with other salmoniformes."
Arnason U., Johnsson E., Rasmussen A.S.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Organisation of the mitochondrial genome from Atlantic salmon (Salmo salar)."
Davidson W.S., Birt T.P., Green J.M.
Genome 32:340-342(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L04502 Genomic DNA. Translation: AAA62409.1.
D84148 Genomic DNA. Translation: BAA20158.1.
U12143 Genomic DNA. Translation: AAD04739.1.
AF133701 Genomic DNA. Translation: AAF61384.1.
PIRT09953.
RefSeqNP_008451.1. NC_001960.1.

3D structure databases

ProteinModelPortalQ36860.
SMRQ36860. Positions 1-261.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808307.

Organism-specific databases

CTD4514.

Phylogenomic databases

HOVERGENHBG016686.
ProtClustDBMTH00130.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. CytC_oxdse_III. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_SALSA
AccessionPrimary (citable) accession number: Q36860
Secondary accession number(s): O03380
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: April 3, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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