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Q36860

- COX3_SALSA

UniProt

Q36860 - COX3_SALSA

Protein

Cytochrome c oxidase subunit 3

Gene

mt-co3

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:mt-co3
    Synonyms:coiii, coxiii, mtco3
    Encoded oniMitochondrion
    OrganismiSalmo salar (Atlantic salmon)
    Taxonomic identifieri8030 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183849Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ36860.
    SMRiQ36860. Positions 1-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016686.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q36860-1 [UniParc]FASTAAdd to Basket

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    MAHQAHAYHM VDPSPWPLTG AIAALLLTSG TAVWFHFHSL TLLTMGNILL    50
    LLTMYQWWRD IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA 100
    FYHSSLSPTP ELGGCWPPTG IITLDPFEVP LLNTAVLLAS GVTVTWAHHS 150
    IMEGERKQTI QALTLTILLG FYFTFLQGME YYEAPFTIAD GVYGSTFFVA 200
    TGFHGLHVII GSTFLAICLL RQIQYHFTSE HHFGFEAAAW YWHFVDVVWL 250
    FLYVSIYWWG S 261
    Length:261
    Mass (Da):29,796
    Last modified:May 30, 2000 - v2
    Checksum:i0E114F391B93C55A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351A → S(PubMed:8000479)Curated
    Sequence conflicti135 – 1351A → S1 PublicationCurated
    Sequence conflicti140 – 1401S → L(PubMed:2744446)Curated
    Sequence conflicti158 – 1581Q → R(PubMed:8000479)Curated
    Sequence conflicti158 – 1581Q → R1 PublicationCurated
    Sequence conflicti159 – 1591T → M(PubMed:2744446)Curated
    Sequence conflicti164 – 1641T → L(PubMed:2744446)Curated
    Sequence conflicti183 – 1842EA → QS(PubMed:2744446)Curated
    Sequence conflicti192 – 1932VY → YT(PubMed:2744446)Curated
    Sequence conflicti216 – 2161A → T(PubMed:2744446)Curated
    Sequence conflicti222 – 2254QIQY → NSMF(PubMed:2744446)Curated
    Sequence conflicti230 – 2301E → K(PubMed:2744446)Curated
    Sequence conflicti237 – 2371A → L(PubMed:8000479)Curated
    Sequence conflicti237 – 2371A → L1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04502 Genomic DNA. Translation: AAA62409.1.
    D84148 Genomic DNA. Translation: BAA20158.1.
    U12143 Genomic DNA. Translation: AAD04739.1.
    AF133701 Genomic DNA. Translation: AAF61384.1.
    PIRiT09953.
    RefSeqiNP_008451.1. NC_001960.1.

    Genome annotation databases

    GeneIDi808307.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L04502 Genomic DNA. Translation: AAA62409.1 .
    D84148 Genomic DNA. Translation: BAA20158.1 .
    U12143 Genomic DNA. Translation: AAD04739.1 .
    AF133701 Genomic DNA. Translation: AAF61384.1 .
    PIRi T09953.
    RefSeqi NP_008451.1. NC_001960.1.

    3D structure databases

    ProteinModelPortali Q36860.
    SMRi Q36860. Positions 1-261.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 808307.

    Organism-specific databases

    CTDi 4514.

    Phylogenomic databases

    HOVERGENi HBG016686.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the Atlantic salmon (Salmo salar) cytochrome c oxidase subunit III gene (coxIII) and analysis of coxIII expression during parr-smolt transformation."
      Hardiman G., Byrnes L., Peden J., Wolff J., Gannon F.
      Mol. Mar. Biol. Biotechnol. 3:210-216(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "Isolation of Atlantic Salmon (Salmo salar) cytochrome c oxidase subunit II gene (coxII)."
      Hardiman G.T., Wolff J., Peden J., Gannon F.
      J. Appl. Ichthyol. 10:64-68(1994)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Kidney.
    3. "Mitochondrial DNA sequence analysis of the masu salmon -- phylogeny in the genus Oncorhynchus."
      Oohara I., Sawano K., Okazaki T.
      Mol. Phylogenet. Evol. 7:71-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo salar."
      Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.
      Gene 239:237-242(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    5. "The complete mitochondrial genome sequence of a teleost, Salmo salar, and comparisons with other salmoniformes."
      Arnason U., Johnsson E., Rasmussen A.S.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Organisation of the mitochondrial genome from Atlantic salmon (Salmo salar)."
      Davidson W.S., Birt T.P., Green J.M.
      Genome 32:340-342(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX3_SALSA
    AccessioniPrimary (citable) accession number: Q36860
    Secondary accession number(s): O03380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3