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Q36724

- COX1_BLAGE

UniProt

Q36724 - COX1_BLAGE

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561Iron (heme A axial ligand)Curated
    Metal bindingi235 – 2351Copper BCurated
    Metal bindingi239 – 2391Copper BCurated
    Metal bindingi285 – 2851Copper BCurated
    Metal bindingi286 – 2861Copper BCurated
    Metal bindingi371 – 3711Iron (heme A3 axial ligand)Curated
    Metal bindingi373 – 3731Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. hydrogen ion transmembrane transport Source: GOC
    3. oxidation-reduction process Source: UniProtKB
    4. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrionImported
    OrganismiBlattella germanica (German cockroach) (Blatta germanica)Imported
    Taxonomic identifieri6973 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 508›508Cytochrome c oxidase subunit 1PRO_0000183295Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki235 ↔ 2391'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined. Highest levels in gut and fat body, lower levels in ovary and collateral glands.1 Publication

    Developmental stagei

    Levels increase 3-fold during embryo development with the highest level in 17 day old embryos. Relatively low levels in larvae and adults.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ36724.
    SMRiQ36724. Positions 1-502.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini‹1 – 6›6Mitochondrial matrixBy similarity
    Topological domaini36 – 4510Mitochondrial intermembraneBy similarity
    Topological domaini82 – 898Mitochondrial matrixBy similarity
    Topological domaini113 – 13523Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini166 – 17712Mitochondrial matrixBy similarityAdd
    BLAST
    Topological domaini208 – 22215Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini257 – 2648Mitochondrial matrixBy similarity
    Topological domaini282 – 29312Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini323 – 3308Mitochondrial matrixBy similarity
    Topological domaini353 – 36513Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini396 – 4016Mitochondrial matrixBy similarity
    Topological domaini429 – 44113Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini474 – 50835Mitochondrial matrixBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 3529Helical; Name=IBy similarityAdd
    BLAST
    Transmembranei46 – 8136Helical; Name=IIBy similarityAdd
    BLAST
    Transmembranei90 – 11223Helical; Name=IIIBy similarityAdd
    BLAST
    Transmembranei136 – 16530Helical; Name=IVBy similarityAdd
    BLAST
    Transmembranei178 – 20730Helical; Name=VBy similarityAdd
    BLAST
    Transmembranei223 – 25634Helical; Name=VIBy similarityAdd
    BLAST
    Transmembranei265 – 28117Helical; Name=VIIBy similarityAdd
    BLAST
    Transmembranei294 – 32229Helical; Name=VIIIBy similarityAdd
    BLAST
    Transmembranei331 – 35222Helical; Name=IXBy similarityAdd
    BLAST
    Transmembranei366 – 39530Helical; Name=XBy similarityAdd
    BLAST
    Transmembranei402 – 42827Helical; Name=XIBy similarityAdd
    BLAST
    Transmembranei442 – 47332Helical; Name=XIIBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q36724-1 [UniParc]FASTAAdd to Basket

    « Hide

    WLFSTNHKDI GTLYFIFGAW SGMVGMSLSM LIRAELNQPG SLIGDDQIYN    50
    VIVTAHAFVM IFFMVMPILI GGFGNWLVPL MLGAPDMAFP RMNNMSFWFL 100
    PPSLSLLLAS SLVESGAGTG WTLYPPLASG IAHAGASVDL AIFSLHLAGV 150
    SSILGAVNFI STIINMKPIN MSPERIPLFV WSVGITALLL LLSLPVLAGA 200
    ITMLLTDRNL NTSFFDPAGG GDPILYQHLF WFFGHPEVYI LILPGFGMIS 250
    HIICHESGKK EAFGNLGMIF AMLAIGLLGF VVWAHHMFTV GMDVDTRAYF 300
    TSATMIIAVP TGIKIFSWLA TMYGSQLTYS APCLWALGFV FLFTVGGLTG 350
    VVLANSSIDI VLHDTYYVVA HFHYVLSMGA VFAIMAGFIQ WYPLFTGLSL 400
    NPKWLKIQFS IMFLGVNLTF FPQHFLGLAG MPRRYSDYPD AYTAWNVISS 450
    IGSMISFVAV LMFIFIMWES MSSNRQVLFP TQTSNSIEWF QNIPPAEHSY 500
    AELPTISY 508
    Length:508
    Mass (Da):56,001
    Last modified:November 1, 1996 - v1
    Checksum:i48B5BE46771C10DD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S72627 mRNA. Translation: AAB31450.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S72627 mRNA. Translation: AAB31450.2 .

    3D structure databases

    ProteinModelPortali Q36724.
    SMRi Q36724. Positions 1-502.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome c oxidase subunit I from the cockroach Blattella germanica: cloning, developmental pattern and tissue expression."
      Martinez-Gonzalez J., Hegardt F.G.
      Insect Biochem. Mol. Biol. 24:619-626(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCOX1_BLAGE
    AccessioniPrimary (citable) accession number: Q36724
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3