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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Iron (heme A axial ligand)Curated1
Metal bindingi235Copper BCurated1
Metal bindingi239Copper BCurated1
Metal bindingi285Copper BCurated1
Metal bindingi286Copper BCurated1
Metal bindingi371Iron (heme A3 axial ligand)Curated1
Metal bindingi373Iron (heme A axial ligand)Curated1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: UniProtKB
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro

GO - Biological processi

  • aerobic respiration Source: InterPro
  • oxidation-reduction process Source: UniProtKB
  • oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrionImported
OrganismiBlattella germanica (German cockroach) (Blatta germanica)Imported
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 6Mitochondrial matrixBy similarity›6
Transmembranei7 – 35Helical; Name=IBy similarityAdd BLAST29
Topological domaini36 – 45Mitochondrial intermembraneBy similarity10
Transmembranei46 – 81Helical; Name=IIBy similarityAdd BLAST36
Topological domaini82 – 89Mitochondrial matrixBy similarity8
Transmembranei90 – 112Helical; Name=IIIBy similarityAdd BLAST23
Topological domaini113 – 135Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei136 – 165Helical; Name=IVBy similarityAdd BLAST30
Topological domaini166 – 177Mitochondrial matrixBy similarityAdd BLAST12
Transmembranei178 – 207Helical; Name=VBy similarityAdd BLAST30
Topological domaini208 – 222Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei223 – 256Helical; Name=VIBy similarityAdd BLAST34
Topological domaini257 – 264Mitochondrial matrixBy similarity8
Transmembranei265 – 281Helical; Name=VIIBy similarityAdd BLAST17
Topological domaini282 – 293Mitochondrial intermembraneBy similarityAdd BLAST12
Transmembranei294 – 322Helical; Name=VIIIBy similarityAdd BLAST29
Topological domaini323 – 330Mitochondrial matrixBy similarity8
Transmembranei331 – 352Helical; Name=IXBy similarityAdd BLAST22
Topological domaini353 – 365Mitochondrial intermembraneBy similarityAdd BLAST13
Transmembranei366 – 395Helical; Name=XBy similarityAdd BLAST30
Topological domaini396 – 401Mitochondrial matrixBy similarity6
Transmembranei402 – 428Helical; Name=XIBy similarityAdd BLAST27
Topological domaini429 – 441Mitochondrial intermembraneBy similarityAdd BLAST13
Transmembranei442 – 473Helical; Name=XIIBy similarityAdd BLAST32
Topological domaini474 – 508Mitochondrial matrixBy similarityAdd BLAST35

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB
  • respiratory chain complex IV Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183295‹1 – 508Cytochrome c oxidase subunit 1Add BLAST›508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki235 ↔ 2391'-histidyl-3'-tyrosine (His-Tyr)By similarity

Expressioni

Tissue specificityi

Expressed in all tissues examined. Highest levels in gut and fat body, lower levels in ovary and collateral glands.1 Publication

Developmental stagei

Levels increase 3-fold during embryo development with the highest level in 17 day old embryos. Relatively low levels in larvae and adults.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ36724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q36724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
WLFSTNHKDI GTLYFIFGAW SGMVGMSLSM LIRAELNQPG SLIGDDQIYN
60 70 80 90 100
VIVTAHAFVM IFFMVMPILI GGFGNWLVPL MLGAPDMAFP RMNNMSFWFL
110 120 130 140 150
PPSLSLLLAS SLVESGAGTG WTLYPPLASG IAHAGASVDL AIFSLHLAGV
160 170 180 190 200
SSILGAVNFI STIINMKPIN MSPERIPLFV WSVGITALLL LLSLPVLAGA
210 220 230 240 250
ITMLLTDRNL NTSFFDPAGG GDPILYQHLF WFFGHPEVYI LILPGFGMIS
260 270 280 290 300
HIICHESGKK EAFGNLGMIF AMLAIGLLGF VVWAHHMFTV GMDVDTRAYF
310 320 330 340 350
TSATMIIAVP TGIKIFSWLA TMYGSQLTYS APCLWALGFV FLFTVGGLTG
360 370 380 390 400
VVLANSSIDI VLHDTYYVVA HFHYVLSMGA VFAIMAGFIQ WYPLFTGLSL
410 420 430 440 450
NPKWLKIQFS IMFLGVNLTF FPQHFLGLAG MPRRYSDYPD AYTAWNVISS
460 470 480 490 500
IGSMISFVAV LMFIFIMWES MSSNRQVLFP TQTSNSIEWF QNIPPAEHSY

AELPTISY
Length:508
Mass (Da):56,001
Last modified:November 1, 1996 - v1
Checksum:i48B5BE46771C10DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72627 mRNA. Translation: AAB31450.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72627 mRNA. Translation: AAB31450.2.

3D structure databases

ProteinModelPortaliQ36724.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_BLAGE
AccessioniPrimary (citable) accession number: Q36724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.