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Q36724

- COX1_BLAGE

UniProt

Q36724 - COX1_BLAGE

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Iron (heme A axial ligand) InferredBy similarity
Metal bindingi235 – 2351Copper B InferredBy similarity
Metal bindingi239 – 2391Copper B InferredBy similarity
Metal bindingi285 – 2851Copper B InferredBy similarity
Metal bindingi286 – 2861Copper B InferredBy similarity
Metal bindingi371 – 3711Iron (heme A3 axial ligand) InferredBy similarity
Metal bindingi373 – 3731Iron (heme A axial ligand) InferredBy similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. hydrogen ion transmembrane transport Source: GOC
  3. oxidation-reduction process Source: UniProtKB
  4. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 6›6Mitochondrial matrix By similarityBy similarity
Transmembranei7 – 3529Helical; Name=I; By similarityBy similarity
Add
BLAST
Topological domaini36 – 4510Mitochondrial intermembrane By similarityBy similarity
Transmembranei46 – 8136Helical; Name=II; By similarityBy similarity
Add
BLAST
Topological domaini82 – 898Mitochondrial matrix By similarityBy similarity
Transmembranei90 – 11223Helical; Name=III; By similarityBy similarity
Add
BLAST
Topological domaini113 – 13523Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei136 – 16530Helical; Name=IV; By similarityBy similarity
Add
BLAST
Topological domaini166 – 17712Mitochondrial matrix By similarityBy similarity
Add
BLAST
Transmembranei178 – 20730Helical; Name=V; By similarityBy similarity
Add
BLAST
Topological domaini208 – 22215Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei223 – 25634Helical; Name=VI; By similarityBy similarity
Add
BLAST
Topological domaini257 – 2648Mitochondrial matrix By similarityBy similarity
Transmembranei265 – 28117Helical; Name=VII; By similarityBy similarity
Add
BLAST
Topological domaini282 – 29312Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei294 – 32229Helical; Name=VIII; By similarityBy similarity
Add
BLAST
Topological domaini323 – 3308Mitochondrial matrix By similarityBy similarity
Transmembranei331 – 35222Helical; Name=IX; By similarityBy similarity
Add
BLAST
Topological domaini353 – 36513Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei366 – 39530Helical; Name=X; By similarityBy similarity
Add
BLAST
Topological domaini396 – 4016Mitochondrial matrix By similarityBy similarity
Transmembranei402 – 42827Helical; Name=XI; By similarityBy similarity
Add
BLAST
Topological domaini429 – 44113Mitochondrial intermembrane By similarityBy similarity
Add
BLAST
Transmembranei442 – 47332Helical; Name=XII; By similarityBy similarity
Add
BLAST
Topological domaini474 – 50835Mitochondrial matrix By similarityBy similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 508›508Cytochrome c oxidase subunit 1
PRO_0000183295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki235 ↔ 2391'-histidyl-3'-tyrosine (His-Tyr) By similarity

Expressioni

Tissue specificityi

Expressed in all tissues examined. Highest levels in gut and fat body, lower levels in ovary and collateral glands.1 Publication

Developmental stagei

Levels increase 3-fold during embryo development with the highest level in 17 day old embryos. Relatively low levels in larvae and adults.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ36724.
SMRiQ36724. Positions 1-502.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q36724-1 [UniParc]FASTAAdd to Basket

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WLFSTNHKDI GTLYFIFGAW SGMVGMSLSM LIRAELNQPG SLIGDDQIYN    50
VIVTAHAFVM IFFMVMPILI GGFGNWLVPL MLGAPDMAFP RMNNMSFWFL 100
PPSLSLLLAS SLVESGAGTG WTLYPPLASG IAHAGASVDL AIFSLHLAGV 150
SSILGAVNFI STIINMKPIN MSPERIPLFV WSVGITALLL LLSLPVLAGA 200
ITMLLTDRNL NTSFFDPAGG GDPILYQHLF WFFGHPEVYI LILPGFGMIS 250
HIICHESGKK EAFGNLGMIF AMLAIGLLGF VVWAHHMFTV GMDVDTRAYF 300
TSATMIIAVP TGIKIFSWLA TMYGSQLTYS APCLWALGFV FLFTVGGLTG 350
VVLANSSIDI VLHDTYYVVA HFHYVLSMGA VFAIMAGFIQ WYPLFTGLSL 400
NPKWLKIQFS IMFLGVNLTF FPQHFLGLAG MPRRYSDYPD AYTAWNVISS 450
IGSMISFVAV LMFIFIMWES MSSNRQVLFP TQTSNSIEWF QNIPPAEHSY 500
AELPTISY 508
Length:508
Mass (Da):56,001
Last modified:November 1, 1996 - v1
Checksum:i48B5BE46771C10DD
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72627 mRNA. Translation: AAB31450.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72627 mRNA. Translation: AAB31450.2 .

3D structure databases

ProteinModelPortali Q36724.
SMRi Q36724. Positions 1-502.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytochrome c oxidase subunit I from the cockroach Blattella germanica: cloning, developmental pattern and tissue expression."
    Martinez-Gonzalez J., Hegardt F.G.
    Insect Biochem. Mol. Biol. 24:619-626(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCOX1_BLAGE
AccessioniPrimary (citable) accession number: Q36724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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