Q36675 (COX3_PLAVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COIII

Encoded on

Mitochondrion

Organism

Plasmodium vivax

Taxonomic identifier

5855 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Plasmodium)

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Cytochrome c oxidase subunit 3		PRO_0000183834
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Transmembrane	241 – 261	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q36675 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 76E26FAF697491CD	FASTA	263	30,281
	10 20 30 40 50 60 MLTAHKITVL INIFFIFSNY NNIKAHLVSY PSLTSLYGTS LKYFSVGILF TSNPIIFIIF 70 80 90 100 110 120 VYSIRESFYS IFSSLVSGML SIIISEAILF ITYFWGILHF SLSPYPLYNE GIILTSSRML 130 140 150 160 170 180 ILTITFILAS ASCMTACLQF LIEKGMSLEI SSIVFIIYLL GECFASLQTT EYLHLGYCIN 190 200 210 220 230 240 DAISGTLFYC VTGLHFSHVI VGLLLLLIYF IRIVEMYDTN SEWSYSLYGI SYIVLPHTDQ 250 260 ITILYWHFVE IVWLFIEYFF YSE

References

[1]

"Cytochrome c oxidase III (COIII) gene of Plasmodium vivax: complete coding sequence and its expression in the erythhrocytic stages of the parasite." Lim P.K.C., Kita K., Tan S.K., Furuta T., Kojima S., Aoki T., Watanabe Y., Mak J.W. Kisechugaku Zasshi 45:373-383(1996) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D82020 Genomic DNA. Translation: BAA11509.1.
3D structure databases
ProteinModelPortal	Q36675.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_PLAVI

Accession

Primary (citable) accession number: Q36675

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	March 6, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)