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Q36450 (NDUS2_NICSY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH dehydrogenase subunit 7
Gene names
Name:NAD7
Encoded onMitochondrion
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
Taxonomic identifier4096 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. HAMAP-Rule MF_01358

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01358

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01358

Subunit structure

Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMitochondrion
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 HAMAP-Rule MF_01358
PRO_0000118585

Sequences

Sequence LengthMass (Da)Tools
Q36450 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4DCA5173BAC46258

FASTA39444,522
        10         20         30         40         50         60 
MTTKNRQIKN FTSNFGPQHP AAHGVSRSVL EMNGEVVERA EPHIGLLQRG TEKLIEYKTY 

        70         80         90        100        110        120 
LQALPYSDRS EYVSMMAQEH AHSSAVERLL NCEVPLRAQY IRVLFREITR ISNHSLALTT 

       130        140        150        160        170        180 
HAMDVGASTP FLWAFEEREK LLEFYERVSG ARMHASFIRP GGVAQDLPLG LCIDIDSFTQ 

       190        200        210        220        230        240 
QFASRIDELE EMSTGNRIWK QRLVDIGTVT AQQAKDWGFS GVMLRGSGVC WDLRKAAPYD 

       250        260        270        280        290        300 
VHDQLDPDIP VGTRGDRYDR YCIRIEEMRQ SVRIIVQCLN QMPSGMIKAD DRKLCPPSRS 

       310        320        330        340        350        360 
RMKLSMESSI HHFEPYTEGF SVPAPSTYTA VEAPKGEFGV FLVSNGSNRP YRRKIRAPCF 

       370        380        390 
AHSQGLDSMS KHHMPADVVT IIGTQDIVSG EVDR 

« Hide

References

[1]"Deletion of the last two exons of the mitochondrial nad7 gene results in lack of the NAD7 polypeptide in a Nicotiana sylvestris CMS mutant."
Pla M., Mathieu C., De Paepe R., Chetrit P., Vedel F.
Mol. Gen. Genet. 248:79-88(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X86706 mRNA. Translation: CAA60392.1.

3D structure databases

ProteinModelPortalQ36450.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR022885. NDH1_su_D/H.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNDUS2_NICSY
AccessionPrimary (citable) accession number: Q36450
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families