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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

Gene

NAD7

Organism
Nicotiana sylvestris (Wood tobacco) (South American tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiNicotiana sylvestris (Wood tobacco) (South American tobacco)
Taxonomic identifieri4096 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185851 – 394NADH dehydrogenase [ubiquinone] iron-sulfur protein 2Add BLAST394

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ36450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit

Sequencei

Sequence statusi: Complete.

Q36450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKNRQIKN FTSNFGPQHP AAHGVSRSVL EMNGEVVERA EPHIGLLQRG
60 70 80 90 100
TEKLIEYKTY LQALPYSDRS EYVSMMAQEH AHSSAVERLL NCEVPLRAQY
110 120 130 140 150
IRVLFREITR ISNHSLALTT HAMDVGASTP FLWAFEEREK LLEFYERVSG
160 170 180 190 200
ARMHASFIRP GGVAQDLPLG LCIDIDSFTQ QFASRIDELE EMSTGNRIWK
210 220 230 240 250
QRLVDIGTVT AQQAKDWGFS GVMLRGSGVC WDLRKAAPYD VHDQLDPDIP
260 270 280 290 300
VGTRGDRYDR YCIRIEEMRQ SVRIIVQCLN QMPSGMIKAD DRKLCPPSRS
310 320 330 340 350
RMKLSMESSI HHFEPYTEGF SVPAPSTYTA VEAPKGEFGV FLVSNGSNRP
360 370 380 390
YRRKIRAPCF AHSQGLDSMS KHHMPADVVT IIGTQDIVSG EVDR
Length:394
Mass (Da):44,522
Last modified:November 1, 1996 - v1
Checksum:i4DCA5173BAC46258
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86706 mRNA Translation: CAA60392.1

Similar proteinsi

Entry informationi

Entry nameiNDUS2_NICSY
AccessioniPrimary (citable) accession number: Q36450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health