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Q36421

- COX1_LOCMI

UniProt

Q36421 - COX1_LOCMI

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Locusta migratoria (Migratory locust)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand) Inferred
Metal bindingi239 – 2391Copper B Inferred
Metal bindingi243 – 2431Copper B Inferred
Metal bindingi289 – 2891Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi375 – 3751Iron (heme A3 axial ligand) Inferred
Metal bindingi377 – 3771Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiLocusta migratoria (Migratory locust)
Taxonomic identifieri7004 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeOedipodinaeLocusta

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Transmembranei267 – 28721Helical; Reviewed prediction
Add
BLAST
Transmembranei307 – 32721Helical; Reviewed prediction
Add
BLAST
Transmembranei337 – 35721Helical; Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Transmembranei413 – 43321Helical; Reviewed prediction
Add
BLAST
Transmembranei451 – 47121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome c oxidase subunit 1
PRO_0000183354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ36421.
SMRiQ36421. Positions 4-512.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q36421-1 [UniParc]FASTAAdd to Basket

« Hide

MTQKWLFSTN HKDIGTLYFM FGAWAGMVGT SMSMIIRAEL GQPGTMINDD    50
QLYNVIITAH AFVMIFFMVM PIMIGGFGNW LVPLMIGAPD MAFPRMNNMS 100
FWLLPPSLTL LLMSSVVDNG AGTGWTVYPP LASVIAHSGA SVDLAIFSLH 150
LAGVSSILGA INFITTAINM RSNNMTLDQT PLFVWSVAIT ALLLLLSLPV 200
LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP EVYILILPGF 250
GIISHIVCQE SGKIESFGTI GMIYAMLSIG LMGFIVWAHH MFTVGMDVDT 300
RAYFTSATMI IAVPTGIKVF SWMATLYGTK FKFNPPLLWA LGFIFLFTMG 350
GLTGLVLANS SLDIVLHDTY YVVAHFHYVL SMGAVFAIMG GIIQWYPLFT 400
GLTMNSKWLK IQFTIMFIGV NLTFFPQHFL GLAGMPRRYS DYPDAYTSWN 450
VISSIGSTIS ITGIIMFILI MWESMIKQRN VFIWTNMSSS TEWLQNNPPA 500
EHSYSELPLI NL 512
Length:512
Mass (Da):56,814
Last modified:July 15, 1999 - v2
Checksum:i98031A229B00511C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80245 Genomic DNA. Translation: CAA56527.1.
PIRiT11467.
RefSeqiNP_007291.1. NC_001712.1.

Genome annotation databases

GeneIDi807962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80245 Genomic DNA. Translation: CAA56527.1 .
PIRi T11467.
RefSeqi NP_007291.1. NC_001712.1.

3D structure databases

ProteinModelPortali Q36421.
SMRi Q36421. Positions 4-512.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807962.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence, organization, and evolution of the Locusta migratoria mitochondrial genome."
    Flook P.K., Rowell C.H.F., Gellissen G.
    J. Mol. Evol. 41:928-941(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_LOCMI
AccessioniPrimary (citable) accession number: Q36421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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