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Protein

Cytochrome c oxidase subunit 3

Gene

COIII

Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COIII
Synonyms:CO-III
Encoded oniMitochondrion
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Cytochrome c oxidase subunit 3PRO_0000183740Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ36309.
SMRiQ36309. Positions 6-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q36309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQLNHPYHL VNISPWPLAT GMGAFAMTSG LVKWFHSFDS MLFFTGINNN
60 70 80 90 100
HICFDQWWRD VSREATFQGM HSTKVGFGLR WGMILFIISE VFFFVSFFWG
110 120 130 140 150
FFHSSLSPNI EVGALWPPSE VESFLSALLN TSILLASGVT VTWAHHALME
160 170 180 190 200
NNFDQCLQGL LFTVLLGLYF SFLQGLEYME ASFTIADSIY GSTFFLATGF
210 220 230 240 250
HGLHVLIGTI FLMICILRHA KCYFSQHHFG FEAAAWYWHF VDVVWLFLYL

SIYWWGE
Length:257
Mass (Da):29,632
Last modified:November 1, 1996 - v1
Checksum:i4B39F84696740076
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69067 Genomic DNA. Translation: CAA48810.1.
PIRiS60642.
RefSeqiNP_007113.1. NC_001620.1.

Genome annotation databases

GeneIDi807791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69067 Genomic DNA. Translation: CAA48810.1.
PIRiS60642.
RefSeqiNP_007113.1. NC_001620.1.

3D structure databases

ProteinModelPortaliQ36309.
SMRiQ36309. Positions 6-256.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi807791.

Organism-specific databases

CTDi4514.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Speciation in the Artemia genus: mitochondrial DNA analysis of bisexual and parthenogenetic brine shrimps."
    Perez M.L., Valverde J.R., Batuecas B., Amat F., Marco R., Garesse R.
    J. Mol. Evol. 38:156-168(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_ARTSF
AccessioniPrimary (citable) accession number: Q36309
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.