Q36098 (COX3_THEPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	MT-CO3
Synonyms:	COIII, COXIII, MTCO3

Encoded on

Mitochondrion

Organism

Theileria parva (East coast fever infection agent) [Reference proteome]

Taxonomic identifier

5875 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Piroplasmida › Theileriidae › Theileria

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Cytochrome c oxidase subunit 3		PRO_0000232683
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	128 – 148	21	Helical; Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	234 – 254	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q36098 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A3FF61D44AA28844	FASTA	255	29,891
	10 20 30 40 50 60 MRNSAQSYLK YINIINIFET LYLFYSTGLD TLEYIDSTYK NFIIMYVNQY LLYGTTLKYL 70 80 90 100 110 120 SVGEFFMNSL TIFINSIREI MTSTTMVMYA IFGMFIFSEI LVFSTFIWGY FHLRLSNPIL 130 140 150 160 170 180 LAELNVEAYL QISDVLNTGS ILVSIILHRV QESANFETDF FMEQLLLIGF IFLSLQNDEY 190 200 210 220 230 240 SLILSYVNNY WMTLYFFILT GLHSLHVCAG GIFVLIQSYF YEGDGSQRDE EFNAGVYWHF 250 VEMIWIALTM LLFLA

References

[1]

"A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially-encoded proteins." Kairo A., Fairlamb A., Gobright E., Nene V. EMBO J. 13:898-905(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Muguga.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z23263 Genomic DNA. Translation: CAA80799.1.
PIR	S41690.
RefSeq	YP_001994286.1. NC_011005.1.
3D structure databases
ProteinModelPortal	Q36098.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6741537.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_THEPA

Accession

Primary (citable) accession number: Q36098

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)