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Protein

Cytochrome c oxidase subunit 3

Gene

MT-CO3

Organism
Theileria parva (East coast fever infection agent)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiTheileria parva (East coast fever infection agent)
Taxonomic identifieri5875 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria
ProteomesiUP000001949: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Cytochrome c oxidase subunit 3PRO_0000232683Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ36098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ36098.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q36098-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNSAQSYLK YINIINIFET LYLFYSTGLD TLEYIDSTYK NFIIMYVNQY
60 70 80 90 100
LLYGTTLKYL SVGEFFMNSL TIFINSIREI MTSTTMVMYA IFGMFIFSEI
110 120 130 140 150
LVFSTFIWGY FHLRLSNPIL LAELNVEAYL QISDVLNTGS ILVSIILHRV
160 170 180 190 200
QESANFETDF FMEQLLLIGF IFLSLQNDEY SLILSYVNNY WMTLYFFILT
210 220 230 240 250
GLHSLHVCAG GIFVLIQSYF YEGDGSQRDE EFNAGVYWHF VEMIWIALTM

LLFLA
Length:255
Mass (Da):29,891
Last modified:November 1, 1996 - v1
Checksum:iA3FF61D44AA28844
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23263 Genomic DNA. Translation: CAA80799.1.
PIRiS41690.
RefSeqiYP_001994286.1. NC_011005.1.

Genome annotation databases

GeneIDi6741537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23263 Genomic DNA. Translation: CAA80799.1.
PIRiS41690.
RefSeqiYP_001994286.1. NC_011005.1.

3D structure databases

ProteinModelPortaliQ36098.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6741537.

Phylogenomic databases

InParanoidiQ36098.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially-encoded proteins."
    Kairo A., Fairlamb A., Gobright E., Nene V.
    EMBO J. 13:898-905(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Muguga.

Entry informationi

Entry nameiCOX3_THEPA
AccessioniPrimary (citable) accession number: Q36098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.