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Q36097

- COX1_THEPA

UniProt

Q36097 - COX1_THEPA

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Protein

Cytochrome c oxidase subunit 1

Gene
MT-CO1, COI, COXI, MTCO1
Organism
Theileria parva (East coast fever infection agent)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Iron (heme A axial ligand) By similarity
Metal bindingi246 – 2461Copper B By similarity
Metal bindingi250 – 2501Copper B By similarity
Metal bindingi382 – 3821Iron (heme A3 axial ligand) By similarity
Metal bindingi384 – 3841Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiTheileria parva (East coast fever infection agent)
Taxonomic identifieri5875 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria
ProteomesiUP000001949: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Transmembranei64 – 8421Helical; Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Reviewed predictionAdd
BLAST
Transmembranei194 – 21421Helical; Reviewed predictionAdd
BLAST
Transmembranei240 – 26021Helical; Reviewed predictionAdd
BLAST
Transmembranei278 – 29821Helical; Reviewed predictionAdd
BLAST
Transmembranei309 – 32921Helical; Reviewed predictionAdd
BLAST
Transmembranei343 – 36321Helical; Reviewed predictionAdd
BLAST
Transmembranei382 – 40221Helical; Reviewed predictionAdd
BLAST
Transmembranei420 – 44021Helical; Reviewed predictionAdd
BLAST
Transmembranei459 – 47921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Cytochrome c oxidase subunit 1PRO_0000232688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ36097.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q36097-1 [UniParc]FASTAAdd to Basket

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MKFEGLFLVF NSVSGNHKII GISYLWLAYW FGMIGFYMSV LIRTELSMSG    50
LKIITMDTLE IYNLLFTLHG LIMVFFNIMT GLFGGIGNYL YPVLLGYCDV 100
VYPRVNLYSL LFQPIGFVLV VSSIYLEIGS GTGWTLYPPL STSLSNVGID 150
FIIFGLLAAG IASTLSSVNF ITTFTSVKTI GFVIDRISPA AWSIVLTSFL 200
LLLSLPVVTA VFLMVFLDRH YNTMFFESSN SGDPVLYQHL FWFFGHPEVY 250
IMILPGFGII SLLLSTYTTK EMFGNQTMIL AMGFNSFVRL FGLGTSYVHI 300
RFGSRYSRYF TTVTILIALP TGNKIFNWVT TLQCVESIKS LGLVLFTVLF 350
IVNFVIGGTT GVVLGNAGID LALHDTVYVV GHFHFVLSIG AIISMICFII 400
YIQRMLLFGI ILSNRLSSLI APIFMISVLL TFLPMHFTGF SPLPRRIPDY 450
PDEMWGWNFI CTLGATMMLV LKLAILFIIS L 481
Length:481
Mass (Da):53,792
Last modified:May 2, 2006 - v3
Checksum:iAE044B09BFB9FC86
GO

Sequence cautioni

The sequence CAA80798.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23263 Genomic DNA. Translation: CAA80798.1. Different initiation.
PIRiS41689.
RefSeqiYP_001994285.1. NC_011005.1.

Genome annotation databases

GeneIDi6741532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23263 Genomic DNA. Translation: CAA80798.1 . Different initiation.
PIRi S41689.
RefSeqi YP_001994285.1. NC_011005.1.

3D structure databases

ProteinModelPortali Q36097.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6741532.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially-encoded proteins."
    Kairo A., Fairlamb A., Gobright E., Nene V.
    EMBO J. 13:898-905(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Muguga.

Entry informationi

Entry nameiCOX1_THEPA
AccessioniPrimary (citable) accession number: Q36097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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