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Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Theileria parva (East coast fever infection agent)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Iron (heme A axial ligand)By similarity1
Metal bindingi246Copper BBy similarity1
Metal bindingi250Copper BBy similarity1
Metal bindingi382Iron (heme A3 axial ligand)By similarity1
Metal bindingi384Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded oniMitochondrion
OrganismiTheileria parva (East coast fever infection agent)
Taxonomic identifieri5875 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria
Proteomesi
  • UP000001949 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326881 – 481Cytochrome c oxidase subunit 1Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ36097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ36097.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q36097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFEGLFLVF NSVSGNHKII GISYLWLAYW FGMIGFYMSV LIRTELSMSG
60 70 80 90 100
LKIITMDTLE IYNLLFTLHG LIMVFFNIMT GLFGGIGNYL YPVLLGYCDV
110 120 130 140 150
VYPRVNLYSL LFQPIGFVLV VSSIYLEIGS GTGWTLYPPL STSLSNVGID
160 170 180 190 200
FIIFGLLAAG IASTLSSVNF ITTFTSVKTI GFVIDRISPA AWSIVLTSFL
210 220 230 240 250
LLLSLPVVTA VFLMVFLDRH YNTMFFESSN SGDPVLYQHL FWFFGHPEVY
260 270 280 290 300
IMILPGFGII SLLLSTYTTK EMFGNQTMIL AMGFNSFVRL FGLGTSYVHI
310 320 330 340 350
RFGSRYSRYF TTVTILIALP TGNKIFNWVT TLQCVESIKS LGLVLFTVLF
360 370 380 390 400
IVNFVIGGTT GVVLGNAGID LALHDTVYVV GHFHFVLSIG AIISMICFII
410 420 430 440 450
YIQRMLLFGI ILSNRLSSLI APIFMISVLL TFLPMHFTGF SPLPRRIPDY
460 470 480
PDEMWGWNFI CTLGATMMLV LKLAILFIIS L
Length:481
Mass (Da):53,792
Last modified:May 2, 2006 - v3
Checksum:iAE044B09BFB9FC86
GO

Sequence cautioni

The sequence CAA80798 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23263 Genomic DNA. Translation: CAA80798.1. Different initiation.
PIRiS41689.
RefSeqiYP_001994285.1. NC_011005.1.

Genome annotation databases

GeneIDi6741532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23263 Genomic DNA. Translation: CAA80798.1. Different initiation.
PIRiS41689.
RefSeqiYP_001994285.1. NC_011005.1.

3D structure databases

ProteinModelPortaliQ36097.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6741532.

Phylogenomic databases

InParanoidiQ36097.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_THEPA
AccessioniPrimary (citable) accession number: Q36097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 2, 2006
Last modified: November 30, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.