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Q35539

- COX3_PETMA

UniProt

Q35539 - COX3_PETMA

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Protein

Cytochrome c oxidase subunit 3

Gene
MT-CO3, COIII, COXIII, MTCO3
Organism
Petromyzon marinus (Sea lamprey)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:MT-CO3
Synonyms:COIII, COXIII, MTCO3
Encoded oniMitochondrion
OrganismiPetromyzon marinus (Sea lamprey)
Taxonomic identifieri7757 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed predictionAdd
BLAST
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Transmembranei81 – 10121Helical; Reviewed predictionAdd
BLAST
Transmembranei127 – 14721Helical; Reviewed predictionAdd
BLAST
Transmembranei162 – 18221Helical; Reviewed predictionAdd
BLAST
Transmembranei196 – 21621Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183829Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ35539.
SMRiQ35539. Positions 1-261.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000013064.
HOVERGENiHBG016686.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q35539-1 [UniParc]FASTAAdd to Basket

« Hide

MSHQAHAYHM VDPSPWPLTG AGAALLMTSG LAMWFHKNSC ILMTLGLILM    50
LLTMYQWWRD IVREGTFLGH HTSPVQQGLR YGMILFIISE VCFFAGFFWA 100
FYHASLAPTP ELGLTWPPTG INPLNPFEVP LLNTAVLLAS GVSVTWAHHS 150
ITEKNRTETT QALTLTVLLG LYFTALQIME YYETPFTMAD GVYGSTFFVA 200
TGFHGLHVII GSLFLLTCLL RHLQYHFTSK HHFGFEAAAW YWHFVDVVWL 250
FLYISIYWWG S 261
Length:261
Mass (Da):29,718
Last modified:November 1, 1996 - v1
Checksum:i314B955DCC9A7B7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11880 Genomic DNA. Translation: AAB08744.1.
PIRiS55010.
RefSeqiNP_008154.1. NC_001626.1.

Genome annotation databases

EnsembliENSPMAT00000014129; ENSPMAP00000011437; ENSPMAG00000013102.
GeneIDi807805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U11880 Genomic DNA. Translation: AAB08744.1 .
PIRi S55010.
RefSeqi NP_008154.1. NC_001626.1.

3D structure databases

ProteinModelPortali Q35539.
SMRi Q35539. Positions 1-261.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPMAT00000014129 ; ENSPMAP00000011437 ; ENSPMAG00000013102 .
GeneIDi 807805.

Organism-specific databases

CTDi 4514.

Phylogenomic databases

GeneTreei ENSGT00390000013064.
HOVERGENi HBG016686.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of a sea lamprey (Petromyzon marinus) mitochondrial genome: early establishment of the vertebrate genome organization."
    Lee W.J., Kocher T.D.
    Genetics 139:873-887(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX3_PETMA
AccessioniPrimary (citable) accession number: Q35539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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