Q35242 (COX3_ENTDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COIII

Encoded on

Mitochondrion

Organism

Enteroctopus dofleini (Giant octopus) (Octopus dofleini)

Taxonomic identifier

267067 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Cephalopoda › Coleoidea › Neocoleoidea › Octopodiformes › Octopoda › Incirrata › Octopodidae › Enteroctopus

Protein attributes

Sequence length	204 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›204	›204	Cytochrome c oxidase subunit 3		PRO_0000183814
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	56 – 76	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Transmembrane	171 – 191	21	Helical; Potential
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	204	1

Sequences

	Sequence		Length	Mass (Da)
	Q35242 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7B3451AFC57048C6	FASTA	204	23,425
	10 20 30 40 50 60 LTTGLSSWFH NYGNLLLMLG FLLMIMTMIQ WWRDIIREST FQGFHTTKVY NGLRWGMMLF 70 80 90 100 110 120 IVSEICFFFA FFWAYFHSSL APNTDIGACW PPINIYPLNP FQIPLLNTAI LLSSGVSVTW 130 140 150 160 170 180 AHHSLMSNKL NPAIHSMTIT ITLGFYFTFL QMMEYIEASF SISDSIYGST FFVATGFHGL 190 200 HVIIGSTFLF MCLIRIIMNH FSST

References

[1]	"The molecular phylogeny of five eastern north Pacific octopus species." Barriga Sosa I.A., Beckenbach K., Hartwick B., Smith M.J. Mol. Phylogenet. Evol. 4:163-174(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83103 Genomic DNA. Translation: CAA58165.1.
3D structure databases
ProteinModelPortal	Q35242.
SMR	Q35242. Positions 1-203.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_ENTDO

Accession

Primary (citable) accession number: Q35242

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)