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Q35101

- COX1_METSE

UniProt

Q35101 - COX1_METSE

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Protein

Cytochrome c oxidase subunit 1

Gene
COI
Organism
Metridium senile (Brown sea anemone) (Frilled sea anemone)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand) Inferred
Metal bindingi243 – 2431Copper B Inferred
Metal bindingi247 – 2471Copper B Inferred
Metal bindingi293 – 2931Copper B Inferred
Metal bindingi294 – 2941Copper B Inferred
Metal bindingi379 – 3791Iron (heme A3 axial ligand) Inferred
Metal bindingi381 – 3811Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiMetridium senile (Brown sea anemone) (Frilled sea anemone)
Taxonomic identifieri6116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Reviewed predictionAdd
BLAST
Transmembranei59 – 7921Helical; Reviewed predictionAdd
BLAST
Transmembranei105 – 12521Helical; Reviewed predictionAdd
BLAST
Transmembranei148 – 16821Helical; Reviewed predictionAdd
BLAST
Transmembranei186 – 20621Helical; Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Reviewed predictionAdd
BLAST
Transmembranei270 – 29021Helical; Reviewed predictionAdd
BLAST
Transmembranei313 – 33321Helical; Reviewed predictionAdd
BLAST
Transmembranei341 – 36121Helical; Reviewed predictionAdd
BLAST
Transmembranei380 – 40021Helical; Reviewed predictionAdd
BLAST
Transmembranei417 – 43721Helical; Reviewed predictionAdd
BLAST
Transmembranei455 – 47521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Cytochrome c oxidase subunit 1PRO_0000183362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ35101.
SMRiQ35101. Positions 5-518.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q35101-1 [UniParc]FASTAAdd to Basket

« Hide

MDNKFLTRWV FSTNHKDIGT LYLVFGIGSG MIGTALSMLI RLELSAPGTM    50
LGDDHLYNVI VTAHAFIMIF FLVMPVMIGG FGNWLVPLYI GAPDMAFPRL 100
NNISFWLLPP ALILLLGSAF VEQGVGTGWT VYPPLSAIQA HSGGAVDMAI 150
FSLHLAGASS ILGAMNFITT IFNMRAPGMT MDRLPLFVWS ILITAFLLLL 200
SLPVLAGAIT MLLTDRNFNT TFFDPAGGGD PILFQHLFWF FGHPEVYILI 250
LPGFGMVSQI IPTFSAKNQI FGYLGMVYAM LSIGILGFIV WAHHMFTVGM 300
DVDTRAYFTA ATMIIAVPTG IKVFSWLATI YGGAVRLDTP MLWAIGFVFL 350
FTIGGLTGVI LANSSLDIVL HDTYYVVAHF HYVLSMGAIF AIFAGFYFWF 400
GKITGYCYNE LYGKIHFWIM FIGVNLTFFP QHFLGLAGFP RRYSDFVDGF 450
AGWNLVSSLG STISIVGVIW FVFIVYDAYV REIKFIGWVE NTGASWSSLE 500
WVQPSPPMSH TYNELPFVYG SYSALRPRNS 530
Length:530
Mass (Da):58,770
Last modified:November 1, 1996 - v1
Checksum:iCBD28A5AF94113A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36783 Genomic DNA. Translation: AAC47099.1.
AF000023 Genomic DNA. Translation: AAC04630.1.
PIRiT11884.
RefSeqiNP_009253.1. NC_000933.1.

Genome annotation databases

GeneIDi808778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36783 Genomic DNA. Translation: AAC47099.1 .
AF000023 Genomic DNA. Translation: AAC04630.1 .
PIRi T11884.
RefSeqi NP_009253.1. NC_000933.1.

3D structure databases

ProteinModelPortali Q35101.
SMRi Q35101. Positions 5-518.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808778.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two mitochondrial group I introns in a metazoan, the sea anemone Metridium senile: one intron contains genes for subunits 1 and 3 of NADH dehydrogenase."
    Beagley C.T., Okada N.A., Wolstenholme D.R.
    Proc. Natl. Acad. Sci. U.S.A. 93:5619-5623(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White morph.
  2. Beagley C.T., Okimoto R., Wolstenholme D.R.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White morph.

Entry informationi

Entry nameiCOX1_METSE
AccessioniPrimary (citable) accession number: Q35101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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