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Q35101 (COX1_METSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismMetridium senile (Brown sea anemone) (Frilled sea anemone)
Taxonomic identifier6116 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Cytochrome c oxidase subunit 1
PRO_0000183362

Regions

Transmembrane20 – 4021Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane270 – 29021Helical; Potential
Transmembrane313 – 33321Helical; Potential
Transmembrane341 – 36121Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane417 – 43721Helical; Potential
Transmembrane455 – 47521Helical; Potential

Sites

Metal binding641Iron (heme A axial ligand) Probable
Metal binding2431Copper B Probable
Metal binding2471Copper B Probable
Metal binding2931Copper B Probable
Metal binding2941Copper B Probable
Metal binding3791Iron (heme A3 axial ligand) Probable
Metal binding3811Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q35101 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CBD28A5AF94113A5

FASTA53058,770
        10         20         30         40         50         60 
MDNKFLTRWV FSTNHKDIGT LYLVFGIGSG MIGTALSMLI RLELSAPGTM LGDDHLYNVI 

        70         80         90        100        110        120 
VTAHAFIMIF FLVMPVMIGG FGNWLVPLYI GAPDMAFPRL NNISFWLLPP ALILLLGSAF 

       130        140        150        160        170        180 
VEQGVGTGWT VYPPLSAIQA HSGGAVDMAI FSLHLAGASS ILGAMNFITT IFNMRAPGMT 

       190        200        210        220        230        240 
MDRLPLFVWS ILITAFLLLL SLPVLAGAIT MLLTDRNFNT TFFDPAGGGD PILFQHLFWF 

       250        260        270        280        290        300 
FGHPEVYILI LPGFGMVSQI IPTFSAKNQI FGYLGMVYAM LSIGILGFIV WAHHMFTVGM 

       310        320        330        340        350        360 
DVDTRAYFTA ATMIIAVPTG IKVFSWLATI YGGAVRLDTP MLWAIGFVFL FTIGGLTGVI 

       370        380        390        400        410        420 
LANSSLDIVL HDTYYVVAHF HYVLSMGAIF AIFAGFYFWF GKITGYCYNE LYGKIHFWIM 

       430        440        450        460        470        480 
FIGVNLTFFP QHFLGLAGFP RRYSDFVDGF AGWNLVSSLG STISIVGVIW FVFIVYDAYV 

       490        500        510        520        530 
REIKFIGWVE NTGASWSSLE WVQPSPPMSH TYNELPFVYG SYSALRPRNS 

« Hide

References

[1]"Two mitochondrial group I introns in a metazoan, the sea anemone Metridium senile: one intron contains genes for subunits 1 and 3 of NADH dehydrogenase."
Beagley C.T., Okada N.A., Wolstenholme D.R.
Proc. Natl. Acad. Sci. U.S.A. 93:5619-5623(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: White morph.
[2]Beagley C.T., Okimoto R., Wolstenholme D.R.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: White morph.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36783 Genomic DNA. Translation: AAC47099.1.
AF000023 Genomic DNA. Translation: AAC04630.1.
PIRT11884.
RefSeqNP_009253.1. NC_000933.1.

3D structure databases

ProteinModelPortalQ35101.
SMRQ35101. Positions 5-518.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID808778.

Organism-specific databases

CTD4512.

Phylogenomic databases

ProtClustDBMTH00182.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_METSE
AccessionPrimary (citable) accession number: Q35101
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways