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Q35101

- COX1_METSE

UniProt

Q35101 - COX1_METSE

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Metridium senile (Brown sea anemone) (Frilled sea anemone)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand)Curated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi293 – 2931Copper BCurated
Metal bindingi294 – 2941Copper BCurated
Metal bindingi379 – 3791Iron (heme A3 axial ligand)Curated
Metal bindingi381 – 3811Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiMetridium senile (Brown sea anemone) (Frilled sea anemone)
Taxonomic identifieri6116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeMetridiidaeMetridium

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Cytochrome c oxidase subunit 1PRO_0000183362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ35101.
SMRiQ35101. Positions 5-518.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence AnalysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q35101-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNKFLTRWV FSTNHKDIGT LYLVFGIGSG MIGTALSMLI RLELSAPGTM
60 70 80 90 100
LGDDHLYNVI VTAHAFIMIF FLVMPVMIGG FGNWLVPLYI GAPDMAFPRL
110 120 130 140 150
NNISFWLLPP ALILLLGSAF VEQGVGTGWT VYPPLSAIQA HSGGAVDMAI
160 170 180 190 200
FSLHLAGASS ILGAMNFITT IFNMRAPGMT MDRLPLFVWS ILITAFLLLL
210 220 230 240 250
SLPVLAGAIT MLLTDRNFNT TFFDPAGGGD PILFQHLFWF FGHPEVYILI
260 270 280 290 300
LPGFGMVSQI IPTFSAKNQI FGYLGMVYAM LSIGILGFIV WAHHMFTVGM
310 320 330 340 350
DVDTRAYFTA ATMIIAVPTG IKVFSWLATI YGGAVRLDTP MLWAIGFVFL
360 370 380 390 400
FTIGGLTGVI LANSSLDIVL HDTYYVVAHF HYVLSMGAIF AIFAGFYFWF
410 420 430 440 450
GKITGYCYNE LYGKIHFWIM FIGVNLTFFP QHFLGLAGFP RRYSDFVDGF
460 470 480 490 500
AGWNLVSSLG STISIVGVIW FVFIVYDAYV REIKFIGWVE NTGASWSSLE
510 520 530
WVQPSPPMSH TYNELPFVYG SYSALRPRNS
Length:530
Mass (Da):58,770
Last modified:November 1, 1996 - v1
Checksum:iCBD28A5AF94113A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36783 Genomic DNA. Translation: AAC47099.1.
AF000023 Genomic DNA. Translation: AAC04630.1.
PIRiT11884.
RefSeqiNP_009253.1. NC_000933.1.

Genome annotation databases

GeneIDi808778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36783 Genomic DNA. Translation: AAC47099.1 .
AF000023 Genomic DNA. Translation: AAC04630.1 .
PIRi T11884.
RefSeqi NP_009253.1. NC_000933.1.

3D structure databases

ProteinModelPortali Q35101.
SMRi Q35101. Positions 5-518.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 808778.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two mitochondrial group I introns in a metazoan, the sea anemone Metridium senile: one intron contains genes for subunits 1 and 3 of NADH dehydrogenase."
    Beagley C.T., Okada N.A., Wolstenholme D.R.
    Proc. Natl. Acad. Sci. U.S.A. 93:5619-5623(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White morph.
  2. Beagley C.T., Okimoto R., Wolstenholme D.R.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White morph.

Entry informationi

Entry nameiCOX1_METSE
AccessioniPrimary (citable) accession number: Q35101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3