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Protein

Cytochrome c oxidase subunit 3

Gene

COIII

Organism
Lumbricus terrestris (Common earthworm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COIII
Encoded oniMitochondrion
OrganismiLumbricus terrestris (Common earthworm)
Taxonomic identifieri6398 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeLumbricus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838021 – 259Cytochrome c oxidase subunit 3Add BLAST259

Structurei

3D structure databases

ProteinModelPortaliQ34943.
SMRiQ34943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 1 hit.
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q34943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRQPFHLVE YSPWPLTSSI GAFTLAIGLA SWFHNHGFLC LTLAAFLIIV
60 70 80 90 100
SMIQWWRDVV REGTYMGHHT SLVTTGLRWG MILFITSEVM FFLAFFWAFF
110 120 130 140 150
HSSLSPTPEI GCSWPPTGIH PLNPFSVPLL NTAVLLASGV TVTWAHHSLM
160 170 180 190 200
SGKRIDATQA LILTVCLGAY FTFLQAGEYM AAPFSIADSV YGTTFFVATG
210 220 230 240 250
FHGLHVLIGS SFLAICLART WSHHFSAGHH FGFEAAAWYW HFVDVVWICL

YLCIYWWGS
Length:259
Mass (Da):29,093
Last modified:November 1, 1996 - v1
Checksum:iC974F92A9D8FF045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24570 Genomic DNA. Translation: AAC46867.1.
PIRiS58988.
RefSeqiNP_008241.1. NC_001673.1.

Genome annotation databases

GeneIDi807926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24570 Genomic DNA. Translation: AAC46867.1.
PIRiS58988.
RefSeqiNP_008241.1. NC_001673.1.

3D structure databases

ProteinModelPortaliQ34943.
SMRiQ34943.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi807926.

Organism-specific databases

CTDi4514.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 1 hit.
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_LUMTE
AccessioniPrimary (citable) accession number: Q34943
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.