Q34943 (COX3_LUMTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COIII

Encoded on

Mitochondrion

Organism

Lumbricus terrestris (Common earthworm)

Taxonomic identifier

6398 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Annelida › Clitellata › Oligochaeta › Haplotaxida › Lumbricina › Lumbricidae › Lumbricinae › Lumbricus › Lumbricus terrestris complex

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Cytochrome c oxidase subunit 3		PRO_0000183802
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q34943 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C974F92A9D8FF045	FASTA	259	29,093
	10 20 30 40 50 60 MIRQPFHLVE YSPWPLTSSI GAFTLAIGLA SWFHNHGFLC LTLAAFLIIV SMIQWWRDVV 70 80 90 100 110 120 REGTYMGHHT SLVTTGLRWG MILFITSEVM FFLAFFWAFF HSSLSPTPEI GCSWPPTGIH 130 140 150 160 170 180 PLNPFSVPLL NTAVLLASGV TVTWAHHSLM SGKRIDATQA LILTVCLGAY FTFLQAGEYM 190 200 210 220 230 240 AAPFSIADSV YGTTFFVATG FHGLHVLIGS SFLAICLART WSHHFSAGHH FGFEAAAWYW 250 HFVDVVWICL YLCIYWWGS

References

[1]	"Complete sequence of the mitochondrial DNA of the annelid worm Lumbricus terrestris." Boore J.L., Brown W.M. Genetics 141:305-319(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U24570 Genomic DNA. Translation: AAC46867.1.
PIR	S58988.
RefSeq	NP_008241.1. NC_001673.1.
3D structure databases
ProteinModelPortal	Q34943.
SMR	Q34943. Positions 6-259.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	807926.
Organism-specific databases
CTD	4514.
Phylogenomic databases
ProtClustDB	MTH00009.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_LUMTE

Accession

Primary (citable) accession number: Q34943

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)