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Q34941

- COX1_LUMTE

UniProt

Q34941 - COX1_LUMTE

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Lumbricus terrestris (Common earthworm)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron (heme A axial ligand) Inferred
Metal bindingi237 – 2371Copper B Inferred
Metal bindingi241 – 2411Copper B Inferred
Metal bindingi287 – 2871Copper B Inferred
Metal bindingi288 – 2881Copper B Inferred
Metal bindingi373 – 3731Iron (heme A3 axial ligand) Inferred
Metal bindingi375 – 3751Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiLumbricus terrestris (Common earthworm)
Taxonomic identifieri6398 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeLumbricus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421Helical; Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Transmembranei96 – 11621Helical; Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Reviewed prediction
Add
BLAST
Transmembranei180 – 20021Helical; Reviewed prediction
Add
BLAST
Transmembranei231 – 25121Helical; Reviewed prediction
Add
BLAST
Transmembranei265 – 28521Helical; Reviewed prediction
Add
BLAST
Transmembranei304 – 32421Helical; Reviewed prediction
Add
BLAST
Transmembranei335 – 35521Helical; Reviewed prediction
Add
BLAST
Transmembranei377 – 39721Helical; Reviewed prediction
Add
BLAST
Transmembranei411 – 43121Helical; Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Cytochrome c oxidase subunit 1
PRO_0000183357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki237 ↔ 2411'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ34941.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q34941-1 [UniParc]FASTAAdd to Basket

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MRWFYSTNHK DIGTLYFILG VWAGMVGAGM SLLIRIELSQ PGAFLGSDQL    50
YNTIVTAHXF VMIFFLVMPV FIGGFGNWLL PLMLGAPDMA FPRLNNMSFW 100
LLPPSLILLV SSAAVEKGAG TGWTVYPPLA SNLAHAGPSV DLAIFSLHLA 150
GASSILGAIN FITTVINMRW SGLRLERIPL FVWAVLITVV LLLLSLPVLA 200
GAITMLLTDR NLNTSFFDPA GGGDPILYQH LFWFFGHPEV YILILPGFGA 250
ISHIVSHYTA KLEPFGALGM IYAMLGIAVL GFIVWAHHMF TVGLDVDTRA 300
YFTAVTMIIA VPTGIKVFSW LATIHGSKIK YETPVLWALG FIFLFTTGGL 350
TGIILSNSSL DIILHDTYYV VAHFHYVLSM GAVFAIFAAF THWFPLLTGL 400
TLHHRWANAQ FFLMFLGVNT TFFPQHFLGL SGMPRRYSDY PDAFMKWNVV 450
SSFGSLLSFV ALMLFIFILW EAFASQRSVI SSPHMSSALE WSDPILPLDF 500
HNLSETGIIT YPK 513
Length:513
Mass (Da):56,809
Last modified:November 1, 1996 - v1
Checksum:iECB573C300326B70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24570 Genomic DNA. Translation: AAC46864.1.
PIRiS58985.
RefSeqiNP_008238.1. NC_001673.1.

Genome annotation databases

GeneIDi807923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24570 Genomic DNA. Translation: AAC46864.1 .
PIRi S58985.
RefSeqi NP_008238.1. NC_001673.1.

3D structure databases

ProteinModelPortali Q34941.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807923.

Organism-specific databases

CTDi 4512.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the mitochondrial DNA of the annelid worm Lumbricus terrestris."
    Boore J.L., Brown W.M.
    Genetics 141:305-319(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_LUMTE
AccessioniPrimary (citable) accession number: Q34941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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