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Q34941 (COX1_LUMTE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismLumbricus terrestris (Common earthworm)
Taxonomic identifier6398 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Lophotrochozoa › Annelida › Clitellata › Oligochaeta › Haplotaxida › Lumbricina › Lumbricidae › Lumbricinae › Lumbricus ›

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Cytochrome c oxidase subunit 1
PRO_0000183357

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane335 – 35521Helical; Potential
Transmembrane377 – 39721Helical; Potential
Transmembrane411 – 43121Helical; Potential
Transmembrane453 – 47321Helical; Potential

Sites

Metal binding581Iron (heme A axial ligand) Probable
Metal binding2371Copper B Probable
Metal binding2411Copper B Probable
Metal binding2871Copper B Probable
Metal binding2881Copper B Probable
Metal binding3731Iron (heme A3 axial ligand) Probable
Metal binding3751Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link237 ↔ 2411'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q34941 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: ECB573C300326B70

FASTA51356,809
        10         20         30         40         50         60 
MRWFYSTNHK DIGTLYFILG VWAGMVGAGM SLLIRIELSQ PGAFLGSDQL YNTIVTAHXF 

        70         80         90        100        110        120 
VMIFFLVMPV FIGGFGNWLL PLMLGAPDMA FPRLNNMSFW LLPPSLILLV SSAAVEKGAG 

       130        140        150        160        170        180 
TGWTVYPPLA SNLAHAGPSV DLAIFSLHLA GASSILGAIN FITTVINMRW SGLRLERIPL 

       190        200        210        220        230        240 
FVWAVLITVV LLLLSLPVLA GAITMLLTDR NLNTSFFDPA GGGDPILYQH LFWFFGHPEV 

       250        260        270        280        290        300 
YILILPGFGA ISHIVSHYTA KLEPFGALGM IYAMLGIAVL GFIVWAHHMF TVGLDVDTRA 

       310        320        330        340        350        360 
YFTAVTMIIA VPTGIKVFSW LATIHGSKIK YETPVLWALG FIFLFTTGGL TGIILSNSSL 

       370        380        390        400        410        420 
DIILHDTYYV VAHFHYVLSM GAVFAIFAAF THWFPLLTGL TLHHRWANAQ FFLMFLGVNT 

       430        440        450        460        470        480 
TFFPQHFLGL SGMPRRYSDY PDAFMKWNVV SSFGSLLSFV ALMLFIFILW EAFASQRSVI 

       490        500        510 
SSPHMSSALE WSDPILPLDF HNLSETGIIT YPK

« Hide

References

[1]"Complete sequence of the mitochondrial DNA of the annelid worm Lumbricus terrestris."
Boore J.L., Brown W.M.
Genetics 141:305-319(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U24570 Genomic DNA. Translation: AAC46864.1.
PIRS58985.
RefSeqNP_008238.1. NC_001673.1.

3D structure databases

ProteinModelPortalQ34941.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID807923.

Organism-specific databases

CTD4512.

Phylogenomic databases

ProtClustDBMTH00007.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. COX1. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_LUMTE
AccessionPrimary (citable) accession number: Q34941
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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