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Q34388

- COX1_DROSI

UniProt

Q34388 - COX1_DROSI

Protein

Cytochrome c oxidase subunit 1

Gene

mt:CoI

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron (heme A axial ligand)Curated
    Metal bindingi238 – 2381Copper BCurated
    Metal bindingi242 – 2421Copper BCurated
    Metal bindingi288 – 2881Copper BCurated
    Metal bindingi289 – 2891Copper BCurated
    Metal bindingi374 – 3741Iron (heme A3 axial ligand)Curated
    Metal bindingi376 – 3761Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:mt:CoI
    Synonyms:CoI
    Encoded oniMitochondrion
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000002854: Mitochondrion

    Organism-specific databases

    FlyBaseiFBgn0012877. Dsim\mt:CoI.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Cytochrome c oxidase subunit 1PRO_0000183328Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ34388.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02256.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q34388-1 [UniParc]FASTAAdd to Basket

    « Hide

    PRQWLFSTNH KDIGTLYFIF GAWAGMVGTS LSILIRAELG HPGALIGDDQ    50
    IYNVIVTAHA FIMIFFMVMP IMIGGFGNWL VPLMLGAPDM AFPRMNNMSF 100
    WLLPPALSLL LVSSMVENGA GTGWTVYPPL SAGIAHGGAS VDLAIFSLHL 150
    AGISSILGAV NFITTVINMR STGISLDRMP LFVWSVVITA LLLLLSLPVL 200
    AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG 250
    MISHIISQES GKKETFGSLG MIYAMLAIGL LGFIVWAHHM FTVGMDVDTR 300
    AYFTSATMII AVPTGIKIFS WLATLHGTQL SYSPAILWAL GFVFLFTVGG 350
    LTGVVLANSS VDIILHDTYY VVAHFHYVLS MGAVFAIMAG FIHWYPLFTG 400
    LTLNNKWLKS QFIIMFIGVN LTFFPQHFLG LAGMPRRYSD YPDAYTTWNV 450
    VSTIGSTISL LGILFFFYII WESLVSQRQV IYPIQLNSSI EWYQNTPPAE 500
    HSYSELPLLT N 511
    Length:511
    Mass (Da):56,375
    Last modified:November 28, 2012 - v3
    Checksum:i918CEE06A60210DC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271V → I in AAF77453. (PubMed:10903373)Curated
    Sequence conflicti27 – 271V → I in AAF77427. (PubMed:10903373)Curated
    Sequence conflicti27 – 271V → I in AAF77413. (PubMed:10903373)Curated
    Sequence conflicti27 – 271V → I in AFC97648. (PubMed:23010820)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti450 – 4501V → I in strain: Hawaii, New Caledonia and Tahiti. 2 Publications
    Natural varianti468 – 4681Y → F in strain: Hawaii, New Caledonia and Tahiti. 2 Publications

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200833 Genomic DNA. Translation: AAF77296.1.
    AF200834 Genomic DNA. Translation: AAF77310.1.
    AF200835 Genomic DNA. Translation: AAF77324.1.
    AF200836 Genomic DNA. Translation: AAF77336.1.
    AF200837 Genomic DNA. Translation: AAF77349.1.
    AF200838 Genomic DNA. Translation: AAF77368.1.
    AF200839 Genomic DNA. Translation: AAF77376.1.
    AF200840 Genomic DNA. Translation: AAF77393.1.
    AF200841 Genomic DNA. Translation: AAF77401.1.
    AF200842 Genomic DNA. Translation: AAF77413.1.
    AF200843 Genomic DNA. Translation: AAF77427.1.
    AF200844 Genomic DNA. Translation: AAF77440.1.
    AF200845 Genomic DNA. Translation: AAF77453.1.
    AF200846 Genomic DNA. Translation: AAF77466.1.
    AF200847 Genomic DNA. Translation: AAF77478.1.
    AF200848 Genomic DNA. Translation: AAF77492.1.
    AF200849 Genomic DNA. Translation: AAF77506.1.
    AF200850 Genomic DNA. Translation: AAF77518.1.
    AF200851 Genomic DNA. Translation: AAF77532.1.
    AF200852 Genomic DNA. Translation: AAF77544.1.
    AF200853 Genomic DNA. Translation: AAF77557.1.
    AF200854 Genomic DNA. Translation: AAF77570.1.
    AY518670 Genomic DNA. Translation: AAR91400.1.
    AY518671 Genomic DNA. Translation: AAR91402.1.
    AY518672 Genomic DNA. Translation: AAR91415.1.
    AY518673 Genomic DNA. Translation: AAR91428.1.
    AY518674 Genomic DNA. Translation: AAR91441.1.
    JQ691660 Genomic DNA. Translation: AFC97648.1.
    JQ691661 Genomic DNA. Translation: AFC97661.1.
    M57909 Genomic DNA. Translation: AAB02284.1.
    M57911 Genomic DNA. Translation: AAA66247.2.
    M18072 Genomic DNA. Translation: AAA65482.2.
    S64977 Genomic DNA. Translation: AAD13955.1.
    RefSeqiNP_982323.2. NC_005781.1.

    Genome annotation databases

    GeneIDi2760962.
    KEGGidsi:COX1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200833 Genomic DNA. Translation: AAF77296.1 .
    AF200834 Genomic DNA. Translation: AAF77310.1 .
    AF200835 Genomic DNA. Translation: AAF77324.1 .
    AF200836 Genomic DNA. Translation: AAF77336.1 .
    AF200837 Genomic DNA. Translation: AAF77349.1 .
    AF200838 Genomic DNA. Translation: AAF77368.1 .
    AF200839 Genomic DNA. Translation: AAF77376.1 .
    AF200840 Genomic DNA. Translation: AAF77393.1 .
    AF200841 Genomic DNA. Translation: AAF77401.1 .
    AF200842 Genomic DNA. Translation: AAF77413.1 .
    AF200843 Genomic DNA. Translation: AAF77427.1 .
    AF200844 Genomic DNA. Translation: AAF77440.1 .
    AF200845 Genomic DNA. Translation: AAF77453.1 .
    AF200846 Genomic DNA. Translation: AAF77466.1 .
    AF200847 Genomic DNA. Translation: AAF77478.1 .
    AF200848 Genomic DNA. Translation: AAF77492.1 .
    AF200849 Genomic DNA. Translation: AAF77506.1 .
    AF200850 Genomic DNA. Translation: AAF77518.1 .
    AF200851 Genomic DNA. Translation: AAF77532.1 .
    AF200852 Genomic DNA. Translation: AAF77544.1 .
    AF200853 Genomic DNA. Translation: AAF77557.1 .
    AF200854 Genomic DNA. Translation: AAF77570.1 .
    AY518670 Genomic DNA. Translation: AAR91400.1 .
    AY518671 Genomic DNA. Translation: AAR91402.1 .
    AY518672 Genomic DNA. Translation: AAR91415.1 .
    AY518673 Genomic DNA. Translation: AAR91428.1 .
    AY518674 Genomic DNA. Translation: AAR91441.1 .
    JQ691660 Genomic DNA. Translation: AFC97648.1 .
    JQ691661 Genomic DNA. Translation: AFC97661.1 .
    M57909 Genomic DNA. Translation: AAB02284.1 .
    M57911 Genomic DNA. Translation: AAA66247.2 .
    M18072 Genomic DNA. Translation: AAA65482.2 .
    S64977 Genomic DNA. Translation: AAD13955.1 .
    RefSeqi NP_982323.2. NC_005781.1.

    3D structure databases

    ProteinModelPortali Q34388.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2760962.
    KEGGi dsi:COX1.

    Organism-specific databases

    CTDi 4512.
    FlyBasei FBgn0012877. Dsim\mt:CoI.

    Phylogenomic databases

    KOi K02256.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of mitochondrial DNA in Drosophila simulans."
      Ballard J.W.
      J. Mol. Evol. 51:64-75(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-450 AND PHE-468.
      Strain: C167, DSR, DSW, HW00, HW09, MD106, MD111, MD112, MD119, MD221, MD225, MDW86, NC37, NC48, RU00, RU01, RU07, RU259, RU35, SC00, TT00 and TT01.
    2. "Sequential evolution of a symbiont inferred from the host: Wolbachia and Drosophila simulans."
      Ballard J.W.O.
      Mol. Biol. Evol. 21:428-442(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Australia and Kenya.
    3. "Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans."
      Wolff J.N., Nafisinia M., Sutovsky P., Ballard J.W.
      Heredity 110:57-62(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Kenya.
    4. "Evolution of Drosophila mitochondrial DNA and the history of the melanogaster subgroup."
      Satta Y., Takahata N.
      Proc. Natl. Acad. Sci. U.S.A. 87:9558-9562(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-498, VARIANTS ILE-450 AND PHE-468.
      Strain: Hawaii and Sl3.
    5. "Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species."
      Satta Y., Ishiwa H., Chigusa S.I.
      Mol. Biol. Evol. 4:638-650(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-101.
      Strain: Nairobi.
    6. "Comparative genomics of Drosophila mtDNA: Novel features of conservation and change across functional domains and lineages."
      Montooth K.L., Abt D.N., Hofmann J.W., Rand D.M.
      J. Mol. Evol. 69:94-114(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-10, IDENTIFICATION OF PROBABLE INITIATION SITE.
    7. "Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high level of polymorphism in D. melanogaster."
      Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I.
      Genet. Res. 61:195-204(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-510.

    Entry informationi

    Entry nameiCOX1_DROSI
    AccessioniPrimary (citable) accession number: Q34388
    Secondary accession number(s): H9EAT7
    , H9EAV0, Q34390, Q34393, Q36710, Q9MD75, Q9MDV2, Q9ME63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Caution

    There is no mitochondrial-type translation initiation codon present in frame in the sequence. In PubMed:19533212, the authors suggest the presence of a novel start codon coding for either Pro or Ser in Drosophila CoI transcripts.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3