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Protein

Cytochrome c oxidase subunit 1

Gene

mt:CoI

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme A axial ligand)Curated1
Metal bindingi238Copper BCurated1
Metal bindingi242Copper BCurated1
Metal bindingi288Copper BCurated1
Metal bindingi289Copper BCurated1
Metal bindingi374Iron (heme A3 axial ligand)Curated1
Metal bindingi376Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt:CoI
Synonyms:CoI
Encoded oniMitochondrion
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componenti: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0012877. Dsim\mt:CoI.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833281 – 511Cytochrome c oxidase subunit 1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ34388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q34388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PRQWLFSTNH KDIGTLYFIF GAWAGMVGTS LSILIRAELG HPGALIGDDQ
60 70 80 90 100
IYNVIVTAHA FIMIFFMVMP IMIGGFGNWL VPLMLGAPDM AFPRMNNMSF
110 120 130 140 150
WLLPPALSLL LVSSMVENGA GTGWTVYPPL SAGIAHGGAS VDLAIFSLHL
160 170 180 190 200
AGISSILGAV NFITTVINMR STGISLDRMP LFVWSVVITA LLLLLSLPVL
210 220 230 240 250
AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG
260 270 280 290 300
MISHIISQES GKKETFGSLG MIYAMLAIGL LGFIVWAHHM FTVGMDVDTR
310 320 330 340 350
AYFTSATMII AVPTGIKIFS WLATLHGTQL SYSPAILWAL GFVFLFTVGG
360 370 380 390 400
LTGVVLANSS VDIILHDTYY VVAHFHYVLS MGAVFAIMAG FIHWYPLFTG
410 420 430 440 450
LTLNNKWLKS QFIIMFIGVN LTFFPQHFLG LAGMPRRYSD YPDAYTTWNV
460 470 480 490 500
VSTIGSTISL LGILFFFYII WESLVSQRQV IYPIQLNSSI EWYQNTPPAE
510
HSYSELPLLT N
Length:511
Mass (Da):56,375
Last modified:November 28, 2012 - v3
Checksum:i918CEE06A60210DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27V → I in AAF77453 (PubMed:10903373).Curated1
Sequence conflicti27V → I in AAF77427 (PubMed:10903373).Curated1
Sequence conflicti27V → I in AAF77413 (PubMed:10903373).Curated1
Sequence conflicti27V → I in AFC97648 (PubMed:23010820).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti450V → I in strain: Hawaii, New Caledonia and Tahiti. 2 Publications1
Natural varianti468Y → F in strain: Hawaii, New Caledonia and Tahiti. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200833 Genomic DNA. Translation: AAF77296.1.
AF200834 Genomic DNA. Translation: AAF77310.1.
AF200835 Genomic DNA. Translation: AAF77324.1.
AF200836 Genomic DNA. Translation: AAF77336.1.
AF200837 Genomic DNA. Translation: AAF77349.1.
AF200838 Genomic DNA. Translation: AAF77368.1.
AF200839 Genomic DNA. Translation: AAF77376.1.
AF200840 Genomic DNA. Translation: AAF77393.1.
AF200841 Genomic DNA. Translation: AAF77401.1.
AF200842 Genomic DNA. Translation: AAF77413.1.
AF200843 Genomic DNA. Translation: AAF77427.1.
AF200844 Genomic DNA. Translation: AAF77440.1.
AF200845 Genomic DNA. Translation: AAF77453.1.
AF200846 Genomic DNA. Translation: AAF77466.1.
AF200847 Genomic DNA. Translation: AAF77478.1.
AF200848 Genomic DNA. Translation: AAF77492.1.
AF200849 Genomic DNA. Translation: AAF77506.1.
AF200850 Genomic DNA. Translation: AAF77518.1.
AF200851 Genomic DNA. Translation: AAF77532.1.
AF200852 Genomic DNA. Translation: AAF77544.1.
AF200853 Genomic DNA. Translation: AAF77557.1.
AF200854 Genomic DNA. Translation: AAF77570.1.
AY518670 Genomic DNA. Translation: AAR91400.1.
AY518671 Genomic DNA. Translation: AAR91402.1.
AY518672 Genomic DNA. Translation: AAR91415.1.
AY518673 Genomic DNA. Translation: AAR91428.1.
AY518674 Genomic DNA. Translation: AAR91441.1.
JQ691660 Genomic DNA. Translation: AFC97648.1.
JQ691661 Genomic DNA. Translation: AFC97661.1.
M57909 Genomic DNA. Translation: AAB02284.1.
M57911 Genomic DNA. Translation: AAA66247.2.
M18072 Genomic DNA. Translation: AAA65482.2.
S64977 Genomic DNA. Translation: AAD13955.1.
RefSeqiNP_982323.2. NC_005781.1.

Genome annotation databases

GeneIDi2760962.
KEGGidsi:COX1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200833 Genomic DNA. Translation: AAF77296.1.
AF200834 Genomic DNA. Translation: AAF77310.1.
AF200835 Genomic DNA. Translation: AAF77324.1.
AF200836 Genomic DNA. Translation: AAF77336.1.
AF200837 Genomic DNA. Translation: AAF77349.1.
AF200838 Genomic DNA. Translation: AAF77368.1.
AF200839 Genomic DNA. Translation: AAF77376.1.
AF200840 Genomic DNA. Translation: AAF77393.1.
AF200841 Genomic DNA. Translation: AAF77401.1.
AF200842 Genomic DNA. Translation: AAF77413.1.
AF200843 Genomic DNA. Translation: AAF77427.1.
AF200844 Genomic DNA. Translation: AAF77440.1.
AF200845 Genomic DNA. Translation: AAF77453.1.
AF200846 Genomic DNA. Translation: AAF77466.1.
AF200847 Genomic DNA. Translation: AAF77478.1.
AF200848 Genomic DNA. Translation: AAF77492.1.
AF200849 Genomic DNA. Translation: AAF77506.1.
AF200850 Genomic DNA. Translation: AAF77518.1.
AF200851 Genomic DNA. Translation: AAF77532.1.
AF200852 Genomic DNA. Translation: AAF77544.1.
AF200853 Genomic DNA. Translation: AAF77557.1.
AF200854 Genomic DNA. Translation: AAF77570.1.
AY518670 Genomic DNA. Translation: AAR91400.1.
AY518671 Genomic DNA. Translation: AAR91402.1.
AY518672 Genomic DNA. Translation: AAR91415.1.
AY518673 Genomic DNA. Translation: AAR91428.1.
AY518674 Genomic DNA. Translation: AAR91441.1.
JQ691660 Genomic DNA. Translation: AFC97648.1.
JQ691661 Genomic DNA. Translation: AFC97661.1.
M57909 Genomic DNA. Translation: AAB02284.1.
M57911 Genomic DNA. Translation: AAA66247.2.
M18072 Genomic DNA. Translation: AAA65482.2.
S64977 Genomic DNA. Translation: AAD13955.1.
RefSeqiNP_982323.2. NC_005781.1.

3D structure databases

ProteinModelPortaliQ34388.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2760962.
KEGGidsi:COX1.

Organism-specific databases

CTDi4512.
FlyBaseiFBgn0012877. Dsim\mt:CoI.

Phylogenomic databases

KOiK02256.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_DROSI
AccessioniPrimary (citable) accession number: Q34388
Secondary accession number(s): H9EAT7
, H9EAV0, Q34390, Q34393, Q36710, Q9MD75, Q9MDV2, Q9ME63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 28, 2012
Last modified: November 30, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

There is no mitochondrial-type translation initiation codon present in frame in the sequence. In PubMed:19533212, the authors suggest the presence of a novel start codon coding for either Pro or Ser in Drosophila CoI transcripts.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.