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Q34388

- COX1_DROSI

UniProt

Q34388 - COX1_DROSI

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Protein

Cytochrome c oxidase subunit 1

Gene

mt:CoI

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme A axial ligand)Curated
Metal bindingi238 – 2381Copper BCurated
Metal bindingi242 – 2421Copper BCurated
Metal bindingi288 – 2881Copper BCurated
Metal bindingi289 – 2891Copper BCurated
Metal bindingi374 – 3741Iron (heme A3 axial ligand)Curated
Metal bindingi376 – 3761Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt:CoI
Synonyms:CoI
Encoded oniMitochondrion
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0012877. Dsim\mt:CoI.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence AnalysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Cytochrome c oxidase subunit 1PRO_0000183328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliQ34388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q34388-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PRQWLFSTNH KDIGTLYFIF GAWAGMVGTS LSILIRAELG HPGALIGDDQ
60 70 80 90 100
IYNVIVTAHA FIMIFFMVMP IMIGGFGNWL VPLMLGAPDM AFPRMNNMSF
110 120 130 140 150
WLLPPALSLL LVSSMVENGA GTGWTVYPPL SAGIAHGGAS VDLAIFSLHL
160 170 180 190 200
AGISSILGAV NFITTVINMR STGISLDRMP LFVWSVVITA LLLLLSLPVL
210 220 230 240 250
AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG
260 270 280 290 300
MISHIISQES GKKETFGSLG MIYAMLAIGL LGFIVWAHHM FTVGMDVDTR
310 320 330 340 350
AYFTSATMII AVPTGIKIFS WLATLHGTQL SYSPAILWAL GFVFLFTVGG
360 370 380 390 400
LTGVVLANSS VDIILHDTYY VVAHFHYVLS MGAVFAIMAG FIHWYPLFTG
410 420 430 440 450
LTLNNKWLKS QFIIMFIGVN LTFFPQHFLG LAGMPRRYSD YPDAYTTWNV
460 470 480 490 500
VSTIGSTISL LGILFFFYII WESLVSQRQV IYPIQLNSSI EWYQNTPPAE
510
HSYSELPLLT N
Length:511
Mass (Da):56,375
Last modified:November 28, 2012 - v3
Checksum:i918CEE06A60210DC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271V → I in AAF77453. (PubMed:10903373)Curated
Sequence conflicti27 – 271V → I in AAF77427. (PubMed:10903373)Curated
Sequence conflicti27 – 271V → I in AAF77413. (PubMed:10903373)Curated
Sequence conflicti27 – 271V → I in AFC97648. (PubMed:23010820)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti450 – 4501V → I in strain: Hawaii, New Caledonia and Tahiti. 2 Publications
Natural varianti468 – 4681Y → F in strain: Hawaii, New Caledonia and Tahiti. 2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200833 Genomic DNA. Translation: AAF77296.1.
AF200834 Genomic DNA. Translation: AAF77310.1.
AF200835 Genomic DNA. Translation: AAF77324.1.
AF200836 Genomic DNA. Translation: AAF77336.1.
AF200837 Genomic DNA. Translation: AAF77349.1.
AF200838 Genomic DNA. Translation: AAF77368.1.
AF200839 Genomic DNA. Translation: AAF77376.1.
AF200840 Genomic DNA. Translation: AAF77393.1.
AF200841 Genomic DNA. Translation: AAF77401.1.
AF200842 Genomic DNA. Translation: AAF77413.1.
AF200843 Genomic DNA. Translation: AAF77427.1.
AF200844 Genomic DNA. Translation: AAF77440.1.
AF200845 Genomic DNA. Translation: AAF77453.1.
AF200846 Genomic DNA. Translation: AAF77466.1.
AF200847 Genomic DNA. Translation: AAF77478.1.
AF200848 Genomic DNA. Translation: AAF77492.1.
AF200849 Genomic DNA. Translation: AAF77506.1.
AF200850 Genomic DNA. Translation: AAF77518.1.
AF200851 Genomic DNA. Translation: AAF77532.1.
AF200852 Genomic DNA. Translation: AAF77544.1.
AF200853 Genomic DNA. Translation: AAF77557.1.
AF200854 Genomic DNA. Translation: AAF77570.1.
AY518670 Genomic DNA. Translation: AAR91400.1.
AY518671 Genomic DNA. Translation: AAR91402.1.
AY518672 Genomic DNA. Translation: AAR91415.1.
AY518673 Genomic DNA. Translation: AAR91428.1.
AY518674 Genomic DNA. Translation: AAR91441.1.
JQ691660 Genomic DNA. Translation: AFC97648.1.
JQ691661 Genomic DNA. Translation: AFC97661.1.
M57909 Genomic DNA. Translation: AAB02284.1.
M57911 Genomic DNA. Translation: AAA66247.2.
M18072 Genomic DNA. Translation: AAA65482.2.
S64977 Genomic DNA. Translation: AAD13955.1.
RefSeqiNP_982323.2. NC_005781.1.

Genome annotation databases

GeneIDi2760962.
KEGGidsi:COX1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200833 Genomic DNA. Translation: AAF77296.1 .
AF200834 Genomic DNA. Translation: AAF77310.1 .
AF200835 Genomic DNA. Translation: AAF77324.1 .
AF200836 Genomic DNA. Translation: AAF77336.1 .
AF200837 Genomic DNA. Translation: AAF77349.1 .
AF200838 Genomic DNA. Translation: AAF77368.1 .
AF200839 Genomic DNA. Translation: AAF77376.1 .
AF200840 Genomic DNA. Translation: AAF77393.1 .
AF200841 Genomic DNA. Translation: AAF77401.1 .
AF200842 Genomic DNA. Translation: AAF77413.1 .
AF200843 Genomic DNA. Translation: AAF77427.1 .
AF200844 Genomic DNA. Translation: AAF77440.1 .
AF200845 Genomic DNA. Translation: AAF77453.1 .
AF200846 Genomic DNA. Translation: AAF77466.1 .
AF200847 Genomic DNA. Translation: AAF77478.1 .
AF200848 Genomic DNA. Translation: AAF77492.1 .
AF200849 Genomic DNA. Translation: AAF77506.1 .
AF200850 Genomic DNA. Translation: AAF77518.1 .
AF200851 Genomic DNA. Translation: AAF77532.1 .
AF200852 Genomic DNA. Translation: AAF77544.1 .
AF200853 Genomic DNA. Translation: AAF77557.1 .
AF200854 Genomic DNA. Translation: AAF77570.1 .
AY518670 Genomic DNA. Translation: AAR91400.1 .
AY518671 Genomic DNA. Translation: AAR91402.1 .
AY518672 Genomic DNA. Translation: AAR91415.1 .
AY518673 Genomic DNA. Translation: AAR91428.1 .
AY518674 Genomic DNA. Translation: AAR91441.1 .
JQ691660 Genomic DNA. Translation: AFC97648.1 .
JQ691661 Genomic DNA. Translation: AFC97661.1 .
M57909 Genomic DNA. Translation: AAB02284.1 .
M57911 Genomic DNA. Translation: AAA66247.2 .
M18072 Genomic DNA. Translation: AAA65482.2 .
S64977 Genomic DNA. Translation: AAD13955.1 .
RefSeqi NP_982323.2. NC_005781.1.

3D structure databases

ProteinModelPortali Q34388.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2760962.
KEGGi dsi:COX1.

Organism-specific databases

CTDi 4512.
FlyBasei FBgn0012877. Dsim\mt:CoI.

Phylogenomic databases

KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative genomics of mitochondrial DNA in Drosophila simulans."
    Ballard J.W.
    J. Mol. Evol. 51:64-75(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-450 AND PHE-468.
    Strain: C167, DSR, DSW, HW00, HW09, MD106, MD111, MD112, MD119, MD221, MD225, MDW86, NC37, NC48, RU00, RU01, RU07, RU259, RU35, SC00, TT00 and TT01.
  2. "Sequential evolution of a symbiont inferred from the host: Wolbachia and Drosophila simulans."
    Ballard J.W.O.
    Mol. Biol. Evol. 21:428-442(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Australia and Kenya.
  3. "Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans."
    Wolff J.N., Nafisinia M., Sutovsky P., Ballard J.W.
    Heredity 110:57-62(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Kenya.
  4. "Evolution of Drosophila mitochondrial DNA and the history of the melanogaster subgroup."
    Satta Y., Takahata N.
    Proc. Natl. Acad. Sci. U.S.A. 87:9558-9562(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-498, VARIANTS ILE-450 AND PHE-468.
    Strain: Hawaii and Sl3.
  5. "Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species."
    Satta Y., Ishiwa H., Chigusa S.I.
    Mol. Biol. Evol. 4:638-650(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-101.
    Strain: Nairobi.
  6. "Comparative genomics of Drosophila mtDNA: Novel features of conservation and change across functional domains and lineages."
    Montooth K.L., Abt D.N., Hofmann J.W., Rand D.M.
    J. Mol. Evol. 69:94-114(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-10, IDENTIFICATION OF PROBABLE INITIATION SITE.
  7. "Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high level of polymorphism in D. melanogaster."
    Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I.
    Genet. Res. 61:195-204(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-510.

Entry informationi

Entry nameiCOX1_DROSI
AccessioniPrimary (citable) accession number: Q34388
Secondary accession number(s): H9EAT7
, H9EAV0, Q34390, Q34393, Q36710, Q9MD75, Q9MDV2, Q9ME63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 28, 2012
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

There is no mitochondrial-type translation initiation codon present in frame in the sequence. In PubMed:19533212, the authors suggest the presence of a novel start codon coding for either Pro or Ser in Drosophila CoI transcripts.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3