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Q34345

- COX1_DROMA

UniProt

Q34345 - COX1_DROMA

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Protein
Cytochrome c oxidase subunit 1
Gene
mt:CoI, CoI
Organism
Drosophila mauritiana (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme A axial ligand) Inferred
Metal bindingi238 – 2381Copper B Inferred
Metal bindingi242 – 2421Copper B Inferred
Metal bindingi288 – 2881Copper B Inferred
Metal bindingi289 – 2891Copper B Inferred
Metal bindingi374 – 3741Iron (heme A3 axial ligand) Inferred
Metal bindingi376 – 3761Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt:CoI
Synonyms:CoI
Encoded oniMitochondrion
OrganismiDrosophila mauritiana (Fruit fly)
Taxonomic identifieri7226 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012510. Dmau\mt:CoI.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed prediction
Add
BLAST
Transmembranei54 – 7421Helical; Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Transmembranei181 – 20121Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Transmembranei412 – 43221Helical; Reviewed prediction
Add
BLAST
Transmembranei450 – 47021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Cytochrome c oxidase subunit 1
PRO_0000183324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki238 ↔ 2421'-histidyl-3'-tyrosine (His-Tyr) By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q34345-1 [UniParc]FASTAAdd to Basket

« Hide

PRQWLFSTNH KDIGTLYFIF GAWAGMVGTS LSILIRAELG HPGALIGDDQ    50
IYNVIVTAHA FIMIFFMVMP IMIGGFGNWL VPLMLGAPDM AFPRMNNMSF 100
WLLPPALSLL LVSSMVENGA GTGWTVYPPL SAGIAHGGAS VDLAIFSLHL 150
AGISSILGAV NFITTVINMR STGISLDRMP LFVWSVVITA LLLLLSLPVL 200
AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG 250
MISHIISQES GKKETFGSLG MIYAMLAIGL LGFIVWAHHM FTVGMDVDTR 300
AYFTSATMII AVPTGIKIFS WLATLHGTQL SYSPAILWAL GFVFLFTVGG 350
LTGVVLANSS VDIILHDTYY VVAHFHYVLS MGAVFAIMAG FIHWYPLFTG 400
LTLNNKWLKS HFIIMFIGVN LTFFPQHFLG LAGMPRRYSD YPDAYTTWNV 450
VSTIGSTISL LGILFFFYII WESLVSQRQV IYPIQLNSSI EWYQNTPPAE 500
HSYSELPLLT N 511
Length:511
Mass (Da):56,384
Last modified:November 28, 2012 - v3
Checksum:iCD7F3FEBB056369E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti411 – 4111H → Q in strain: G52 and BG1. 2 Publications

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18073 Genomic DNA. Translation: AAA69804.2.
M57907 Genomic DNA. Translation: AAB02280.1.
AF200830 Genomic DNA. Translation: AAF77258.1.
AF200831 Genomic DNA. Translation: AAF77277.1.
M57912 Genomic DNA. Translation: AAA99051.1.
RefSeqiNP_987108.2. NC_005779.1.

Genome annotation databases

GeneIDi2760929.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18073 Genomic DNA. Translation: AAA69804.2 .
M57907 Genomic DNA. Translation: AAB02280.1 .
AF200830 Genomic DNA. Translation: AAF77258.1 .
AF200831 Genomic DNA. Translation: AAF77277.1 .
M57912 Genomic DNA. Translation: AAA99051.1 .
RefSeqi NP_987108.2. NC_005779.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2760929.

Organism-specific databases

CTDi 4512.
FlyBasei FBgn0012510. Dmau\mt:CoI.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of Drosophila mitochondrial DNA and the history of the melanogaster subgroup."
    Satta Y., Takahata N.
    Proc. Natl. Acad. Sci. U.S.A. 87:9558-9562(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-411.
    Strain: G52 and Mauritius island.
  2. "Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup."
    Ballard J.W.O.
    J. Mol. Evol. 51:48-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-411.
    Strain: BG1 and G52.
  3. "Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species."
    Satta Y., Ishiwa H., Chigusa S.I.
    Mol. Biol. Evol. 4:638-650(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-101.
    Strain: Mauritius island.
  4. "Comparative genomics of Drosophila mtDNA: Novel features of conservation and change across functional domains and lineages."
    Montooth K.L., Abt D.N., Hofmann J.W., Rand D.M.
    J. Mol. Evol. 69:94-114(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.

Entry informationi

Entry nameiCOX1_DROMA
AccessioniPrimary (citable) accession number: Q34345
Secondary accession number(s): Q34346
, Q34350, Q7IV58, Q7IV62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

There is no mitochondrial-type translation initiation codon present in frame in the sequence. In 1 Publication, the authors suggest the presence of a novel start codon coding for either Pro or Ser in Drosophila CoI transcripts.

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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