Q33E94 (RFX4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor RFX4

Alternative name(s):
Regulatory factor X 4
Testis development protein NYD-SP10

Gene names

Name:

RFX4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	735 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May activate transcription by interacting directly with the X-box By similarity.
Subunit structure	Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA.
Subcellular location	Nucleus By similarity.
Tissue specificity	Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes. Ref.2 Ref.3 Ref.8
Sequence similarities	Belongs to the RFX family. Contains 1 RFX-type winged-helix DNA-binding domain.
Sequence caution	The sequence BAB59001.1 differs from that shown. Reason: Probable intron retention. The sequence BAC11288.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAE48237.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAE48238.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cerebellar cortex morphogenesis Inferred from electronic annotation. Source: Ensembl dorsal spinal cord development Inferred from electronic annotation. Source: Ensembl forebrain development Inferred from electronic annotation. Source: Ensembl midbrain development Inferred from electronic annotation. Source: Ensembl positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Ensembl transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Inferred from electronic annotation. Source: Ensembl
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q33E94-1)

Also known as: RFX4-D; RFX4_v3;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q33E94-2)

Also known as: RFX4-C; RFX4_v4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MHCGLLEEPDMD → MIKRRAHPGAGGDRTRPRRRR

Isoform 3 (identifier: Q33E94-3)

Also known as: RFX4-A; RFX4_v1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-126: TQPVNAASFGKIIRQQFPQLTTRRLGTRGQSK → MNWAAFGGSEFFIPEGIQIDSRCPLSRNITEW

Isoform 4 (identifier: Q33E94-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MHCGLLEEPDMD → MIKRRAHPGAGGDRTRPRRRR
     546-554: AMQSYTWSL → NGKSFKNFG
     555-735: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 735	735	Transcription factor RFX4		PRO_0000314237
Regions
	DNA binding	44 – 126	83
	DNA binding	61 – 136	76	RFX-type winged-helix
	Region	315 – 487	173	Necessary for dimerization
Natural variations
	Alternative sequence	1 – 94	94	Missing in isoform 3.		VSP_030242
	Alternative sequence	1 – 12	12	MHCGL…EPDMD → MIKRRAHPGAGGDRTRPRRR R in isoform 2 and isoform 4.		VSP_030243
	Alternative sequence	95 – 126	32	TQPVN…RGQSK → MNWAAFGGSEFFIPEGIQID SRCPLSRNITEW in isoform 3.		VSP_030244
	Alternative sequence	546 – 554	9	AMQSYTWSL → NGKSFKNFG in isoform 4.		VSP_030245
	Alternative sequence	555 – 735	181	Missing in isoform 4.		VSP_030246
	Natural variant	687	1	S → N. Ref.2 Ref.3		VAR_037873
	Natural variant	698	1	S → A. Corresponds to variant rs17038766 [ dbSNP | Ensembl ].		VAR_057152
Experimental info
	Sequence conflict	417	1	Q → R in AAK17191. Ref.3
	Sequence conflict	423	1	V → E in BAC11288. Ref.4
	Sequence conflict	477	1	A → T in AAH28582. Ref.7
	Sequence conflict	522	1	V → M in AAM52484. Ref.1
	Sequence conflict	549	1	S → A in BAE48231. Ref.2
	Sequence conflict	549	1	S → A in BAE48237. Ref.2
	Sequence conflict	549	1	S → A in BAE48238. Ref.2
	Sequence conflict	549	1	S → A in AAK17191. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RFX4-D) (RFX4_v3) [UniParc]. Last modified May 3, 2011. Version 2. Checksum: 9C2422428B9D7E8B	FASTA	735	83,368
	10 20 30 40 50 60 MHCGLLEEPD MDSTESWIER CLNESENKRY SSHTSLGNVS NDENEEKENN RASKPHSTPA 70 80 90 100 110 120 TLQWLEENYE IAEGVCIPRS ALYMHYLDFC EKNDTQPVNA ASFGKIIRQQ FPQLTTRRLG 130 140 150 160 170 180 TRGQSKYHYY GIAVKESSQY YDVMYSKKGA AWVSETGKKE VSKQTVAYSP RSKLGTLLPE 190 200 210 220 230 240 FPNVKDLNLP ASLPEEKVST FIMMYRTHCQ RILDTVIRAN FDEVQSFLLH FWQGMPPHML 250 260 270 280 290 300 PVLGSSTVVN IVGVCDSILY KAISGVLMPT VLQALPDSLT QVIRKFAKQL DEWLKVALHD 310 320 330 340 350 360 LPENLRNIKF ELSRRFSQIL RRQTSLNHLC QASRTVIHSA DITFQMLEDW RNVDLNSITK 370 380 390 400 410 420 QTLYTMEDSR DEHRKLITQL YQEFDHLLEE QSPIESYIEW LDTMVDRCVV KVAAKRQGSL 430 440 450 460 470 480 KKVAQQFLLM WSCFGTRVIR DMTLHSAPSF GSFHLIHLMF DDYVLYLLES LHCQERANEL 490 500 510 520 530 540 MRAMKGEGST AEVREEIILT EAAAPTPSPV PSFSPAKSAT SVEVPPPSSP VSNPSPEYTG 550 560 570 580 590 600 LSTTGAMQSY TWSLTYTVTT AAGSPAENSQ QLPCMRNTHV PSSSVTHRIP VYPHREEHGY 610 620 630 640 650 660 TGSYNYGSYG NQHPHPMQSQ YPALPHDTAI SGPLHYAPYH RSSAQYPFNS PTSRMEPCLM 670 680 690 700 710 720 SSTPRLHPTP VTPRWPEVPS ANTCYTSPSV HSARYGNSSD MYTPLTTRRN SEYEHMQHFP 730 GFAYINGEAS TGWAK
	Isoform 2 (RFX4-C) (RFX4_v4) [UniParc]. Checksum: 5A36FF5CB5D8EFB7	FASTA	744	84,479
	10 20 30 40 50 60 MIKRRAHPGA GGDRTRPRRR RSTESWIERC LNESENKRYS SHTSLGNVSN DENEEKENNR 70 80 90 100 110 120 ASKPHSTPAT LQWLEENYEI AEGVCIPRSA LYMHYLDFCE KNDTQPVNAA SFGKIIRQQF 130 140 150 160 170 180 PQLTTRRLGT RGQSKYHYYG IAVKESSQYY DVMYSKKGAA WVSETGKKEV SKQTVAYSPR 190 200 210 220 230 240 SKLGTLLPEF PNVKDLNLPA SLPEEKVSTF IMMYRTHCQR ILDTVIRANF DEVQSFLLHF 250 260 270 280 290 300 WQGMPPHMLP VLGSSTVVNI VGVCDSILYK AISGVLMPTV LQALPDSLTQ VIRKFAKQLD 310 320 330 340 350 360 EWLKVALHDL PENLRNIKFE LSRRFSQILR RQTSLNHLCQ ASRTVIHSAD ITFQMLEDWR 370 380 390 400 410 420 NVDLNSITKQ TLYTMEDSRD EHRKLITQLY QEFDHLLEEQ SPIESYIEWL DTMVDRCVVK 430 440 450 460 470 480 VAAKRQGSLK KVAQQFLLMW SCFGTRVIRD MTLHSAPSFG SFHLIHLMFD DYVLYLLESL 490 500 510 520 530 540 HCQERANELM RAMKGEGSTA EVREEIILTE AAAPTPSPVP SFSPAKSATS VEVPPPSSPV 550 560 570 580 590 600 SNPSPEYTGL STTGAMQSYT WSLTYTVTTA AGSPAENSQQ LPCMRNTHVP SSSVTHRIPV 610 620 630 640 650 660 YPHREEHGYT GSYNYGSYGN QHPHPMQSQY PALPHDTAIS GPLHYAPYHR SSAQYPFNSP 670 680 690 700 710 720 TSRMEPCLMS STPRLHPTPV TPRWPEVPSA NTCYTSPSVH SARYGNSSDM YTPLTTRRNS 730 740 EYEHMQHFPG FAYINGEAST GWAK
	Isoform 3 (RFX4-A) (RFX4_v1) [UniParc]. Checksum: 55FD9787E6771AF8	FASTA	641	72,561
	10 20 30 40 50 60 MNWAAFGGSE FFIPEGIQID SRCPLSRNIT EWYHYYGIAV KESSQYYDVM YSKKGAAWVS 70 80 90 100 110 120 ETGKKEVSKQ TVAYSPRSKL GTLLPEFPNV KDLNLPASLP EEKVSTFIMM YRTHCQRILD 130 140 150 160 170 180 TVIRANFDEV QSFLLHFWQG MPPHMLPVLG SSTVVNIVGV CDSILYKAIS GVLMPTVLQA 190 200 210 220 230 240 LPDSLTQVIR KFAKQLDEWL KVALHDLPEN LRNIKFELSR RFSQILRRQT SLNHLCQASR 250 260 270 280 290 300 TVIHSADITF QMLEDWRNVD LNSITKQTLY TMEDSRDEHR KLITQLYQEF DHLLEEQSPI 310 320 330 340 350 360 ESYIEWLDTM VDRCVVKVAA KRQGSLKKVA QQFLLMWSCF GTRVIRDMTL HSAPSFGSFH 370 380 390 400 410 420 LIHLMFDDYV LYLLESLHCQ ERANELMRAM KGEGSTAEVR EEIILTEAAA PTPSPVPSFS 430 440 450 460 470 480 PAKSATSVEV PPPSSPVSNP SPEYTGLSTT GAMQSYTWSL TYTVTTAAGS PAENSQQLPC 490 500 510 520 530 540 MRNTHVPSSS VTHRIPVYPH REEHGYTGSY NYGSYGNQHP HPMQSQYPAL PHDTAISGPL 550 560 570 580 590 600 HYAPYHRSSA QYPFNSPTSR MEPCLMSSTP RLHPTPVTPR WPEVPSANTC YTSPSVHSAR 610 620 630 640 YGNSSDMYTP LTTRRNSEYE HMQHFPGFAY INGEASTGWA K
	Isoform 4 [UniParc]. Checksum: 67D9817BB0BC6B9E	FASTA	563	64,181
	10 20 30 40 50 60 MIKRRAHPGA GGDRTRPRRR RSTESWIERC LNESENKRYS SHTSLGNVSN DENEEKENNR 70 80 90 100 110 120 ASKPHSTPAT LQWLEENYEI AEGVCIPRSA LYMHYLDFCE KNDTQPVNAA SFGKIIRQQF 130 140 150 160 170 180 PQLTTRRLGT RGQSKYHYYG IAVKESSQYY DVMYSKKGAA WVSETGKKEV SKQTVAYSPR 190 200 210 220 230 240 SKLGTLLPEF PNVKDLNLPA SLPEEKVSTF IMMYRTHCQR ILDTVIRANF DEVQSFLLHF 250 260 270 280 290 300 WQGMPPHMLP VLGSSTVVNI VGVCDSILYK AISGVLMPTV LQALPDSLTQ VIRKFAKQLD 310 320 330 340 350 360 EWLKVALHDL PENLRNIKFE LSRRFSQILR RQTSLNHLCQ ASRTVIHSAD ITFQMLEDWR 370 380 390 400 410 420 NVDLNSITKQ TLYTMEDSRD EHRKLITQLY QEFDHLLEEQ SPIESYIEWL DTMVDRCVVK 430 440 450 460 470 480 VAAKRQGSLK KVAQQFLLMW SCFGTRVIRD MTLHSAPSFG SFHLIHLMFD DYVLYLLESL 490 500 510 520 530 540 HCQERANELM RAMKGEGSTA EVREEIILTE AAAPTPSPVP SFSPAKSATS VEVPPPSSPV 550 560 SNPSPEYTGL STTGNGKSFK NFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4." Blackshear P.J., Graves J.P., Stumpo D.J., Cobos I., Rubenstein J.L.R., Zeldin D.C. Development 130:4539-4552(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients." Matsushita H., Uenaka A., Ono T., Hasegawa K., Sato S., Koizumi F., Nakagawa K., Toda M., Shingo T., Ichikawa T., Noguchi Y., Tamiya T., Furuta T., Kawase T., Date I., Nakayama E. Cancer Sci. 96:801-809(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANT ASN-687. Tissue: Astrocytoma and Testis.
[3]	"Identification of a novel substrate for tyrosine kinase in human testes." Huang X., Zhou Z., Yin L., Zhu H., Wang L., Lin M., Zhou Y., Sha J. J. Nanosci. Nanotechnol. 5:1236-1239(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANT ASN-687. Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain and Testis.
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[8]	"Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members." Morotomi-Yano K., Yano K., Saito H., Sun Z., Iwama A., Miki Y. J. Biol. Chem. 277:836-842(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-545 (ISOFORM 4), TISSUE SPECIFICITY, INTERACTION WITH RFX2 AND RFX3.
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-735 (ISOFORM 1). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY102009 mRNA. Translation: AAM52484.1. AB095365 mRNA. Translation: BAE48231.1. AB095366 mRNA. Translation: BAE48232.1. AB195784 mRNA. Translation: BAE48237.1. Different initiation. AB195785 mRNA. Translation: BAE48238.1. Different initiation. AF332192 mRNA. Translation: AAK17191.1. AK074913 mRNA. Translation: BAC11288.1. Different initiation. AK291445 mRNA. Translation: BAF84134.1. AK315698 mRNA. Translation: BAG38061.1. AC009721 Genomic DNA. No translation available. AC079385 Genomic DNA. No translation available. CH471054 Genomic DNA. Translation: EAW97783.1. CH471054 Genomic DNA. Translation: EAW97784.1. CH471054 Genomic DNA. Translation: EAW97782.1. BC028582 mRNA. Translation: AAH28582.1. BC030644 mRNA. Translation: AAH30644.1. AB044245 mRNA. Translation: BAB59001.1. Sequence problems. AL833921 mRNA. Translation: CAD38777.1.
IPI	IPI00165990. IPI00419901. IPI00719141. IPI00878891.
RefSeq	NP_001193620.1. NM_001206691.1. NP_115880.2. NM_032491.5. NP_998759.1. NM_213594.2.
UniGene	Hs.388827.
3D structure databases
ProteinModelPortal	Q33E94.
SMR	Q33E94. Positions 61-135.
ModBase	Search...
PTM databases
PhosphoSite	Q33E94.
Polymorphism databases
DMDM	121946871.
Proteomic databases
PaxDb	Q33E94.
PRIDE	Q33E94.
Protocols and materials databases
DNASU	5992.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229387; ENSP00000229387; ENSG00000111783. ENST00000357881; ENSP00000350552; ENSG00000111783. ENST00000392842; ENSP00000376585; ENSG00000111783.
GeneID	5992.
KEGG	hsa:5992.
UCSC	uc001tlr.3. human.
Organism-specific databases
CTD	5992.
GeneCards	GC12P106976.
H-InvDB	HIX0037058.
HGNC	HGNC:9985. RFX4.
HPA	HPA050527.
MIM	603958. gene.
neXtProt	NX_Q33E94.
PharmGKB	PA34355.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG243313.
HOVERGEN	HBG101271.
KO	K09174.
OMA	GAMQSYT.
OrthoDB	EOG79CXXT.
PhylomeDB	Q33E94.
Gene expression databases
ArrayExpress	Q33E94.
Bgee	Q33E94.
Genevestigator	Q33E94.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR003150. DNA-bd_RFX. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF02257. RFX_DNA_binding. 1 hit. [Graphical view]
PROSITE	PS51526. RFX_DBD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GeneWiki	RFX4.
GenomeRNAi	5992.
NextBio	23341.
PRO	Q33E94.
SOURCE	Search...

Entry information

Entry name

RFX4_HUMAN

Accession

Primary (citable) accession number: Q33E94
Secondary accession number(s): A8K5Y0 , B2RDW4, Q33DW6, Q33DW7, Q33E95, Q6YM53, Q8MHQ1, Q8NC78, Q8NDF9, Q8SNA1, Q96S80, Q9BXI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 3, 2011
Last modified:	November 13, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.