SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q33DR3

- DLP1_MOUSE

UniProt

Q33DR3 - DLP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Decaprenyl-diphosphate synthase subunit 2
Gene
Pdss2, Dlp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.1 Publication

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.1 Publication

Pathwayi

GO - Molecular functioni

  1. protein heterodimerization activity Source: HGNC
  2. trans-hexaprenyltranstransferase activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. isoprenoid biosynthetic process Source: HGNC
  2. protein heterotetramerization Source: MGI
  3. regulation of body fluid levels Source: MGI
  4. ubiquinone biosynthetic process Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

ReactomeiREACT_196568. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Decaprenyl-diphosphate synthase subunit 2 (EC:2.5.1.91)
Alternative name(s):
All-trans-decaprenyl-diphosphate synthase subunit 2
Decaprenyl pyrophosphate synthase subunit 2
Solanesyl-diphosphate synthase subunit 2
Gene namesi
Name:Pdss2
Synonyms:Dlp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1918615. Pdss2.

Subcellular locationi

Mitochondrion Reviewed prediction

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Decaprenyl-diphosphate synthase subunit 2
PRO_0000123979Add
BLAST

Proteomic databases

MaxQBiQ33DR3.
PaxDbiQ33DR3.
PRIDEiQ33DR3.

PTM databases

PhosphoSiteiQ33DR3.

Expressioni

Gene expression databases

ArrayExpressiQ33DR3.
BgeeiQ33DR3.
GenevestigatoriQ33DR3.

Interactioni

Subunit structurei

Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093393.

Structurei

3D structure databases

ProteinModelPortaliQ33DR3.
SMRiQ33DR3. Positions 73-385.

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.

Phylogenomic databases

eggNOGiCOG0142.
GeneTreeiENSGT00530000063378.
HOGENOMiHOG000294216.
HOVERGENiHBG058860.
InParanoidiB2RWA7.
KOiK12505.
OMAiNNLQMRG.
OrthoDBiEOG7XPZ5X.
PhylomeDBiQ33DR3.
TreeFamiTF354277.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q33DR3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLRQLLLRL SGYLGASGPP SRHWWYFRSL DSISSAGSWR GRSSRSPAHW    50
NQVVSEAEKI VGYPASFMSL RCLLSDELSN IAMQVRKLVG TGHPLLTTAR 100
ALVHDSRHNL QLRGLVVLLI SKAAGPSTRN AACQNYDMVS GVYSCQRSLA 150
EITELIHTAL LVHRGIVNLS ELQSSDGPLK DMQFGNKIAI LSGDFLLANA 200
CNGLALLQNT KVVELLSSAL MDLVHGVYQE NSASTKENSI PDDIGISTWK 250
EQTFLSHCAL LAKSCQAAME LAKHDAAVQD MAFQYGKHMA MSHKINADLQ 300
PFIKDKASDS KTFNLNSAPV VLHQEFLGRD LWIKQIGEAQ EKGSLNYSKL 350
RETIKAGKGV TSAIDLCRYH GNKALEALES FPPSEARSAL ENIVFAVTRF 400
S 401
Length:401
Mass (Da):43,980
Last modified:January 24, 2006 - v2
Checksum:iDB7835A83019E5AA
GO
Isoform 2 (identifier: Q33DR3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-352: LRE → VVS
     353-401: Missing.

Note: No experimental confirmation available.

Show »
Length:352
Mass (Da):38,618
Checksum:i22895FB1C1B55490
GO
Isoform 3 (identifier: Q33DR3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-264: VELLSSALMD...LSHCALLAKS → KAERLTCAHT...DGDLGSDNMK
     265-401: Missing.

Show »
Length:264
Mass (Da):28,599
Checksum:iEDE79A90E66D6F6E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei213 – 26452VELLS…LLAKS → KAERLTCAHTASGVSCLAAE ATDRGVCVLLLSSSMWMLTE TDDGDLGSDNMK in isoform 3.
VSP_017102Add
BLAST
Alternative sequencei265 – 401137Missing in isoform 3.
VSP_017103Add
BLAST
Alternative sequencei350 – 3523LRE → VVS in isoform 2.
VSP_017104
Alternative sequencei353 – 40149Missing in isoform 2.
VSP_017105Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321A → S in BAE48218. 1 Publication
Sequence conflicti204 – 2041L → I in BAB30693. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB210840 mRNA. Translation: BAE48218.1.
AK017329 mRNA. Translation: BAB30693.1.
AK140091 mRNA. Translation: BAE24234.1.
BC147693 mRNA. Translation: AAI47694.1.
BC147694 mRNA. Translation: AAI47695.1.
BC147752 mRNA. Translation: AAI47753.1.
BC147753 mRNA. Translation: AAI47754.1.
CCDSiCCDS35891.1. [Q33DR3-1]
CCDS48552.1. [Q33DR3-2]
RefSeqiNP_001161761.1. NM_001168289.1. [Q33DR3-2]
NP_082048.2. NM_027772.2. [Q33DR3-1]
XP_006512914.1. XM_006512851.1. [Q33DR3-1]
UniGeneiMm.490430.

Genome annotation databases

EnsembliENSMUST00000095725; ENSMUSP00000093393; ENSMUSG00000038240. [Q33DR3-1]
ENSMUST00000159139; ENSMUSP00000124864; ENSMUSG00000038240. [Q33DR3-2]
GeneIDi71365.
KEGGimmu:71365.
UCSCiuc007ezh.2. mouse. [Q33DR3-3]
uc007ezi.2. mouse. [Q33DR3-1]
uc011xdk.1. mouse. [Q33DR3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB210840 mRNA. Translation: BAE48218.1 .
AK017329 mRNA. Translation: BAB30693.1 .
AK140091 mRNA. Translation: BAE24234.1 .
BC147693 mRNA. Translation: AAI47694.1 .
BC147694 mRNA. Translation: AAI47695.1 .
BC147752 mRNA. Translation: AAI47753.1 .
BC147753 mRNA. Translation: AAI47754.1 .
CCDSi CCDS35891.1. [Q33DR3-1 ]
CCDS48552.1. [Q33DR3-2 ]
RefSeqi NP_001161761.1. NM_001168289.1. [Q33DR3-2 ]
NP_082048.2. NM_027772.2. [Q33DR3-1 ]
XP_006512914.1. XM_006512851.1. [Q33DR3-1 ]
UniGenei Mm.490430.

3D structure databases

ProteinModelPortali Q33DR3.
SMRi Q33DR3. Positions 73-385.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000093393.

PTM databases

PhosphoSitei Q33DR3.

Proteomic databases

MaxQBi Q33DR3.
PaxDbi Q33DR3.
PRIDEi Q33DR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095725 ; ENSMUSP00000093393 ; ENSMUSG00000038240 . [Q33DR3-1 ]
ENSMUST00000159139 ; ENSMUSP00000124864 ; ENSMUSG00000038240 . [Q33DR3-2 ]
GeneIDi 71365.
KEGGi mmu:71365.
UCSCi uc007ezh.2. mouse. [Q33DR3-3 ]
uc007ezi.2. mouse. [Q33DR3-1 ]
uc011xdk.1. mouse. [Q33DR3-2 ]

Organism-specific databases

CTDi 57107.
MGIi MGI:1918615. Pdss2.

Phylogenomic databases

eggNOGi COG0142.
GeneTreei ENSGT00530000063378.
HOGENOMi HOG000294216.
HOVERGENi HBG058860.
InParanoidi B2RWA7.
KOi K12505.
OMAi NNLQMRG.
OrthoDBi EOG7XPZ5X.
PhylomeDBi Q33DR3.
TreeFami TF354277.

Enzyme and pathway databases

UniPathwayi UPA00232 .
Reactomei REACT_196568. Ubiquinol biosynthesis.

Miscellaneous databases

ChiTaRSi PDSS2. mouse.
NextBioi 333637.
PROi Q33DR3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q33DR3.
Bgeei Q33DR3.
Genevestigatori Q33DR3.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view ]
PANTHERi PTHR12001. PTHR12001. 1 hit.
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans."
    Saiki R., Nagata A., Kainou T., Matsuda H., Kawamukai M.
    FEBS J. 272:5606-5622(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiDLP1_MOUSE
AccessioniPrimary (citable) accession number: Q33DR3
Secondary accession number(s): B2RWA7
, B2RWF3, Q3USU6, Q9D3K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi