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Protein

Decaprenyl-diphosphate synthase subunit 1

Gene

Pdss1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.1 Publication

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.1 Publication

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128Isopentenyl diphosphateBy similarity1
Binding sitei131Isopentenyl diphosphateBy similarity1
Binding sitei167Isopentenyl diphosphateBy similarity1
Metal bindingi174Magnesium 1By similarity1
Metal bindingi174Magnesium 2By similarity1
Metal bindingi178Magnesium 1By similarity1
Metal bindingi178Magnesium 2By similarity1
Binding sitei183Polyprenyl diphosphateBy similarity1
Binding sitei184Isopentenyl diphosphateBy similarity1
Binding sitei260Polyprenyl diphosphateBy similarity1
Binding sitei261Polyprenyl diphosphateBy similarity1
Binding sitei298Polyprenyl diphosphateBy similarity1
Metal bindingi301Magnesium 3By similarity1
Binding sitei315Polyprenyl diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • isoprenoid biosynthetic process Source: HGNC
  • protein heterotetramerization Source: MGI
  • ubiquinone biosynthetic process Source: HGNC

Keywordsi

Molecular functionTransferase
Biological processIsoprene biosynthesis, Ubiquinone biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2142789. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Decaprenyl-diphosphate synthase subunit 1 (EC:2.5.1.91)
Alternative name(s):
All-trans-decaprenyl-diphosphate synthase subunit 1
Decaprenyl pyrophosphate synthase subunit 1
Solanesyl-diphosphate synthase subunit 1
Trans-prenyltransferase 1
Short name:
TPT 1
Gene namesi
Name:Pdss1
Synonyms:Dps1, Sps1, Tprt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1889278. Pdss1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239761 – 409Decaprenyl-diphosphate synthase subunit 1Add BLAST409

Proteomic databases

EPDiQ33DR2.
MaxQBiQ33DR2.
PaxDbiQ33DR2.
PeptideAtlasiQ33DR2.
PRIDEiQ33DR2.

PTM databases

iPTMnetiQ33DR2.
PhosphoSitePlusiQ33DR2.
SwissPalmiQ33DR2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026784.
ExpressionAtlasiQ33DR2. baseline and differential.
GenevisibleiQ33DR2. MM.

Interactioni

Subunit structurei

Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: HGNC

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055689.

Structurei

3D structure databases

ProteinModelPortaliQ33DR2.
SMRiQ33DR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiKOG0776. Eukaryota.
COG0142. LUCA.
GeneTreeiENSGT00530000063378.
HOGENOMiHOG000009104.
HOVERGENiHBG054389.
InParanoidiQ33DR2.
KOiK12504.
OMAiGKQMRPM.
OrthoDBiEOG091G1BWC.
PhylomeDBiQ33DR2.
TreeFamiTF313548.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiView protein in InterPro
IPR008949. Isoprenoid_synthase_dom_sf.
IPR000092. Polyprenyl_synt.
IPR033749. Polyprenyl_synt_CS.
PfamiView protein in Pfam
PF00348. polyprenyl_synt. 1 hit.
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiView protein in PROSITE
PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q33DR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRWSCWRR GCSWRPTAVG SPRRERPGCV EPLGTRAASD TRAQIPYFSL
60 70 80 90 100
MKILMSASPT MHSISQFHQR TPAMCSCRQT QSGEKYSDPF KLGWRDLKGL
110 120 130 140 150
YEDIRKELHI STRELKDMSE YYFDGKGKAF RPIIVVLMAR ACNIHHNNAR
160 170 180 190 200
EMQASQRSIA LVAEMIHTAT LVHDDVIDDA SSRRGKHTVN KIWGEKKAVL
210 220 230 240 250
AGDLILSAAS VALARIGNTA VVSMLAQVIE DLVRGEFLQL GSKENENERF
260 270 280 290 300
AHYLEKTFKK TASLIANSCK AVSVLGCPDP VVHEIAYQYG KNVGIAFQLI
310 320 330 340 350
DDVLDFTSCS DQMGKPTSAD LKLGIATGPV LFACQQFPEM NAMIMRRFSL
360 370 380 390 400
PGDVDRARQY VLQSDGVQQT TYLAQQYCHK AVREIRKLRP STERDALIQL

SESVLTRDK
Length:409
Mass (Da):45,895
Last modified:December 6, 2005 - v1
Checksum:iEF94459BD78F48B2
GO

Sequence cautioni

The sequence AAD24462 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH26820 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in AAH26820 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210841 mRNA. Translation: BAE48219.1.
CT030013 Genomic DNA. Translation: CAX15884.1.
BC026820 mRNA. Translation: AAH26820.1. Different initiation.
BC107273 mRNA. Translation: AAI07274.2.
BC107274 mRNA. Translation: AAI07275.2.
AF118855 mRNA. Translation: AAD24462.1. Different initiation.
CCDSiCCDS38057.1.
RefSeqiNP_062374.2. NM_019501.3.
UniGeneiMm.249752.

Genome annotation databases

EnsembliENSMUST00000053729; ENSMUSP00000055689; ENSMUSG00000026784.
GeneIDi56075.
KEGGimmu:56075.
UCSCiuc008inq.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDPS1_MOUSE
AccessioniPrimary (citable) accession number: Q33DR2
Secondary accession number(s): B8JJW9, Q9WU69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 6, 2005
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families