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Q33DR2

- DPS1_MOUSE

UniProt

Q33DR2 - DPS1_MOUSE

Protein

Decaprenyl-diphosphate synthase subunit 1

Gene

Pdss1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.1 Publication

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.1 Publication

    Cofactori

    Binds 3 magnesium ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei128 – 1281Isopentenyl diphosphateBy similarity
    Binding sitei131 – 1311Isopentenyl diphosphateBy similarity
    Binding sitei167 – 1671Isopentenyl diphosphateBy similarity
    Metal bindingi174 – 1741Magnesium 1By similarity
    Metal bindingi174 – 1741Magnesium 2By similarity
    Metal bindingi178 – 1781Magnesium 1By similarity
    Metal bindingi178 – 1781Magnesium 2By similarity
    Binding sitei183 – 1831Polyprenyl diphosphateBy similarity
    Binding sitei184 – 1841Isopentenyl diphosphateBy similarity
    Binding sitei260 – 2601Polyprenyl diphosphateBy similarity
    Binding sitei261 – 2611Polyprenyl diphosphateBy similarity
    Binding sitei298 – 2981Polyprenyl diphosphateBy similarity
    Metal bindingi301 – 3011Magnesium 3By similarity
    Binding sitei315 – 3151Polyprenyl diphosphateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein heterodimerization activity Source: HGNC
    3. trans-hexaprenyltranstransferase activity Source: Ensembl

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: HGNC
    2. protein heterotetramerization Source: MGI
    3. ubiquinone biosynthetic process Source: HGNC

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Ubiquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BRENDAi2.5.1.11. 3474.
    ReactomeiREACT_196568. Ubiquinol biosynthesis.
    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Decaprenyl-diphosphate synthase subunit 1 (EC:2.5.1.91)
    Alternative name(s):
    All-trans-decaprenyl-diphosphate synthase subunit 1
    Decaprenyl pyrophosphate synthase subunit 1
    Solanesyl-diphosphate synthase subunit 1
    Trans-prenyltransferase 1
    Short name:
    TPT 1
    Gene namesi
    Name:Pdss1
    Synonyms:Dps1, Sps1, Tprt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1889278. Pdss1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Decaprenyl-diphosphate synthase subunit 1PRO_0000123976Add
    BLAST

    Proteomic databases

    PRIDEiQ33DR2.

    PTM databases

    PhosphoSiteiQ33DR2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ33DR2.
    BgeeiQ33DR2.
    GenevestigatoriQ33DR2.

    Interactioni

    Subunit structurei

    Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000055689.

    Structurei

    3D structure databases

    ProteinModelPortaliQ33DR2.
    SMRiQ33DR2. Positions 88-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0142.
    GeneTreeiENSGT00530000063378.
    HOGENOMiHOG000009104.
    HOVERGENiHBG054389.
    InParanoidiQ33DR2.
    KOiK12504.
    OMAiKAFRPMI.
    OrthoDBiEOG7DNNWF.
    PhylomeDBiQ33DR2.
    TreeFamiTF313548.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PANTHERiPTHR12001. PTHR12001. 1 hit.
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q33DR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMRWSCWRR GCSWRPTAVG SPRRERPGCV EPLGTRAASD TRAQIPYFSL    50
    MKILMSASPT MHSISQFHQR TPAMCSCRQT QSGEKYSDPF KLGWRDLKGL 100
    YEDIRKELHI STRELKDMSE YYFDGKGKAF RPIIVVLMAR ACNIHHNNAR 150
    EMQASQRSIA LVAEMIHTAT LVHDDVIDDA SSRRGKHTVN KIWGEKKAVL 200
    AGDLILSAAS VALARIGNTA VVSMLAQVIE DLVRGEFLQL GSKENENERF 250
    AHYLEKTFKK TASLIANSCK AVSVLGCPDP VVHEIAYQYG KNVGIAFQLI 300
    DDVLDFTSCS DQMGKPTSAD LKLGIATGPV LFACQQFPEM NAMIMRRFSL 350
    PGDVDRARQY VLQSDGVQQT TYLAQQYCHK AVREIRKLRP STERDALIQL 400
    SESVLTRDK 409
    Length:409
    Mass (Da):45,895
    Last modified:December 6, 2005 - v1
    Checksum:iEF94459BD78F48B2
    GO

    Sequence cautioni

    The sequence AAD24462.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH26820.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → V in AAH26820. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB210841 mRNA. Translation: BAE48219.1.
    CT030013 Genomic DNA. Translation: CAX15884.1.
    BC026820 mRNA. Translation: AAH26820.1. Different initiation.
    BC107273 mRNA. Translation: AAI07274.2.
    BC107274 mRNA. Translation: AAI07275.2.
    AF118855 mRNA. Translation: AAD24462.1. Different initiation.
    CCDSiCCDS38057.1.
    RefSeqiNP_062374.2. NM_019501.3.
    UniGeneiMm.249752.

    Genome annotation databases

    EnsembliENSMUST00000053729; ENSMUSP00000055689; ENSMUSG00000026784.
    GeneIDi56075.
    KEGGimmu:56075.
    UCSCiuc008inq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB210841 mRNA. Translation: BAE48219.1 .
    CT030013 Genomic DNA. Translation: CAX15884.1 .
    BC026820 mRNA. Translation: AAH26820.1 . Different initiation.
    BC107273 mRNA. Translation: AAI07274.2 .
    BC107274 mRNA. Translation: AAI07275.2 .
    AF118855 mRNA. Translation: AAD24462.1 . Different initiation.
    CCDSi CCDS38057.1.
    RefSeqi NP_062374.2. NM_019501.3.
    UniGenei Mm.249752.

    3D structure databases

    ProteinModelPortali Q33DR2.
    SMRi Q33DR2. Positions 88-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000055689.

    PTM databases

    PhosphoSitei Q33DR2.

    Proteomic databases

    PRIDEi Q33DR2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053729 ; ENSMUSP00000055689 ; ENSMUSG00000026784 .
    GeneIDi 56075.
    KEGGi mmu:56075.
    UCSCi uc008inq.1. mouse.

    Organism-specific databases

    CTDi 23590.
    MGIi MGI:1889278. Pdss1.

    Phylogenomic databases

    eggNOGi COG0142.
    GeneTreei ENSGT00530000063378.
    HOGENOMi HOG000009104.
    HOVERGENi HBG054389.
    InParanoidi Q33DR2.
    KOi K12504.
    OMAi KAFRPMI.
    OrthoDBi EOG7DNNWF.
    PhylomeDBi Q33DR2.
    TreeFami TF313548.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .
    BRENDAi 2.5.1.11. 3474.
    Reactomei REACT_196568. Ubiquinol biosynthesis.

    Miscellaneous databases

    NextBioi 311864.
    PROi Q33DR2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q33DR2.
    Bgeei Q33DR2.
    Genevestigatori Q33DR2.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR017446. Polyprenyl_synth-rel.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    PANTHERi PTHR12001. PTHR12001. 1 hit.
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans."
      Saiki R., Nagata A., Kainou T., Matsuda H., Kawamukai M.
      FEBS J. 272:5606-5622(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Mammary tumor.
    4. "Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency."
      Roetig A., Appelkvist E.-L., Geromel V., Chretien D., Kadhom N., Edery P., Lebideau M., Dallner G., Munnich A., Ernster L., Rustin P.
      Lancet 356:391-395(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-409.

    Entry informationi

    Entry nameiDPS1_MOUSE
    AccessioniPrimary (citable) accession number: Q33DR2
    Secondary accession number(s): B8JJW9, Q9WU69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3