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Protein

Decaprenyl-diphosphate synthase subunit 1

Gene

Pdss1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.1 Publication

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.1 Publication

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281Isopentenyl diphosphateBy similarity
Binding sitei131 – 1311Isopentenyl diphosphateBy similarity
Binding sitei167 – 1671Isopentenyl diphosphateBy similarity
Metal bindingi174 – 1741Magnesium 1By similarity
Metal bindingi174 – 1741Magnesium 2By similarity
Metal bindingi178 – 1781Magnesium 1By similarity
Metal bindingi178 – 1781Magnesium 2By similarity
Binding sitei183 – 1831Polyprenyl diphosphateBy similarity
Binding sitei184 – 1841Isopentenyl diphosphateBy similarity
Binding sitei260 – 2601Polyprenyl diphosphateBy similarity
Binding sitei261 – 2611Polyprenyl diphosphateBy similarity
Binding sitei298 – 2981Polyprenyl diphosphateBy similarity
Metal bindingi301 – 3011Magnesium 3By similarity
Binding sitei315 – 3151Polyprenyl diphosphateBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: HGNC
  3. trans-hexaprenyltranstransferase activity Source: Ensembl

GO - Biological processi

  1. isoprenoid biosynthetic process Source: HGNC
  2. protein heterotetramerization Source: MGI
  3. ubiquinone biosynthetic process Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_309628. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Decaprenyl-diphosphate synthase subunit 1 (EC:2.5.1.91)
Alternative name(s):
All-trans-decaprenyl-diphosphate synthase subunit 1
Decaprenyl pyrophosphate synthase subunit 1
Solanesyl-diphosphate synthase subunit 1
Trans-prenyltransferase 1
Short name:
TPT 1
Gene namesi
Name:Pdss1
Synonyms:Dps1, Sps1, Tprt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1889278. Pdss1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. transferase complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Decaprenyl-diphosphate synthase subunit 1PRO_0000123976Add
BLAST

Proteomic databases

MaxQBiQ33DR2.
PRIDEiQ33DR2.

PTM databases

PhosphoSiteiQ33DR2.

Expressioni

Gene expression databases

BgeeiQ33DR2.
ExpressionAtlasiQ33DR2. baseline and differential.
GenevestigatoriQ33DR2.

Interactioni

Subunit structurei

Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055689.

Structurei

3D structure databases

ProteinModelPortaliQ33DR2.
SMRiQ33DR2. Positions 88-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.Curated

Phylogenomic databases

eggNOGiCOG0142.
GeneTreeiENSGT00530000063378.
HOGENOMiHOG000009104.
HOVERGENiHBG054389.
InParanoidiQ33DR2.
KOiK12504.
OMAiKAFRPMI.
OrthoDBiEOG7DNNWF.
PhylomeDBiQ33DR2.
TreeFamiTF313548.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q33DR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRWSCWRR GCSWRPTAVG SPRRERPGCV EPLGTRAASD TRAQIPYFSL
60 70 80 90 100
MKILMSASPT MHSISQFHQR TPAMCSCRQT QSGEKYSDPF KLGWRDLKGL
110 120 130 140 150
YEDIRKELHI STRELKDMSE YYFDGKGKAF RPIIVVLMAR ACNIHHNNAR
160 170 180 190 200
EMQASQRSIA LVAEMIHTAT LVHDDVIDDA SSRRGKHTVN KIWGEKKAVL
210 220 230 240 250
AGDLILSAAS VALARIGNTA VVSMLAQVIE DLVRGEFLQL GSKENENERF
260 270 280 290 300
AHYLEKTFKK TASLIANSCK AVSVLGCPDP VVHEIAYQYG KNVGIAFQLI
310 320 330 340 350
DDVLDFTSCS DQMGKPTSAD LKLGIATGPV LFACQQFPEM NAMIMRRFSL
360 370 380 390 400
PGDVDRARQY VLQSDGVQQT TYLAQQYCHK AVREIRKLRP STERDALIQL

SESVLTRDK
Length:409
Mass (Da):45,895
Last modified:December 6, 2005 - v1
Checksum:iEF94459BD78F48B2
GO

Sequence cautioni

The sequence AAD24462.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH26820.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → V in AAH26820 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210841 mRNA. Translation: BAE48219.1.
CT030013 Genomic DNA. Translation: CAX15884.1.
BC026820 mRNA. Translation: AAH26820.1. Different initiation.
BC107273 mRNA. Translation: AAI07274.2.
BC107274 mRNA. Translation: AAI07275.2.
AF118855 mRNA. Translation: AAD24462.1. Different initiation.
CCDSiCCDS38057.1.
RefSeqiNP_062374.2. NM_019501.3.
UniGeneiMm.249752.

Genome annotation databases

EnsembliENSMUST00000053729; ENSMUSP00000055689; ENSMUSG00000026784.
GeneIDi56075.
KEGGimmu:56075.
UCSCiuc008inq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210841 mRNA. Translation: BAE48219.1.
CT030013 Genomic DNA. Translation: CAX15884.1.
BC026820 mRNA. Translation: AAH26820.1. Different initiation.
BC107273 mRNA. Translation: AAI07274.2.
BC107274 mRNA. Translation: AAI07275.2.
AF118855 mRNA. Translation: AAD24462.1. Different initiation.
CCDSiCCDS38057.1.
RefSeqiNP_062374.2. NM_019501.3.
UniGeneiMm.249752.

3D structure databases

ProteinModelPortaliQ33DR2.
SMRiQ33DR2. Positions 88-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055689.

PTM databases

PhosphoSiteiQ33DR2.

Proteomic databases

MaxQBiQ33DR2.
PRIDEiQ33DR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053729; ENSMUSP00000055689; ENSMUSG00000026784.
GeneIDi56075.
KEGGimmu:56075.
UCSCiuc008inq.1. mouse.

Organism-specific databases

CTDi23590.
MGIiMGI:1889278. Pdss1.

Phylogenomic databases

eggNOGiCOG0142.
GeneTreeiENSGT00530000063378.
HOGENOMiHOG000009104.
HOVERGENiHBG054389.
InParanoidiQ33DR2.
KOiK12504.
OMAiKAFRPMI.
OrthoDBiEOG7DNNWF.
PhylomeDBiQ33DR2.
TreeFamiTF313548.

Enzyme and pathway databases

UniPathwayiUPA00232.
ReactomeiREACT_309628. Ubiquinol biosynthesis.

Miscellaneous databases

NextBioi311864.
PROiQ33DR2.
SOURCEiSearch...

Gene expression databases

BgeeiQ33DR2.
ExpressionAtlasiQ33DR2. baseline and differential.
GenevestigatoriQ33DR2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans."
    Saiki R., Nagata A., Kainou T., Matsuda H., Kawamukai M.
    FEBS J. 272:5606-5622(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary tumor.
  4. "Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency."
    Roetig A., Appelkvist E.-L., Geromel V., Chretien D., Kadhom N., Edery P., Lebideau M., Dallner G., Munnich A., Ernster L., Rustin P.
    Lancet 356:391-395(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-409.

Entry informationi

Entry nameiDPS1_MOUSE
AccessioniPrimary (citable) accession number: Q33DR2
Secondary accession number(s): B8JJW9, Q9WU69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: December 6, 2005
Last modified: April 1, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.